Results 241 to 250 of about 855,762 (278)

Studies related to antitumor antibiotics. Part VIII. Cleavage of DNA by streptonigrin analogues and the relationship to antineoplastic activity.

Canadian Journal of Biochemistry, 1976
A group of substituted 5,8-quinolinequinones which exhibit antineoplastic activity and which are structurally related to the antitumor antibiotic streptonigrin induce single strand cleavage of PM2 covalently-closed circular-DNA (ccc-DNA) when reductively
J. Lown, S. Sim
semanticscholar   +1 more source

The Toxicologic Evaluation of Marcellomycin—An Antineoplastic Anthracycline Antibiotic

Drug and Chemical Toxicology, 1983
Dose-related toxicologic effects of marcellomycin, an antineoplastic anthracycline antibiotic, were observed in single-dose studies in mice iv (43.05-67.65 mg/m2) and dogs iv (41.0-90.2 mg/m2), and in multiple-dose studies in dogs iv (9.8-29.6 mg/m2 2X/week for 6 weeks) and rats sc (9 weekly doses at 26.2-72.2 mg/m2).
R A, Buroker, D F, Johnson, C R, Comereski, R S, Hirth, H, Madissoo, G H, Hottendorf   +5 more
openaire   +3 more sources

Chronic toxicity of adriamycin: A new antineoplastic antibiotic

Toxicology and Applied Pharmacology, 1972
Abstract Adriamycin, a new antitumor antibiotic, was administered for 3 mo to rabbits and dogs by iv injection of daily single doses of 0.125, 0.250 and 0.5 mg/kg body weight. The lowest dose caused neither mortality nor any sign of toxicity with reference to body weight, blood picture and function and morphology of the liver, kidneys, heart and skin
Tea Chieli, Enrico Solcia, Cesare Bertazzoli, Giuseppe Ricevuti, Giovanni Ferni   +4 more
openaire   +2 more sources

The Toxicological Evaluation of Carminomycin - An Antineoplastic Anthracycline Antibiotic

Drug and Chemical Toxicology, 1981
Carminomycin, an anthracycline antibiotic discovered in the Soviet Union, possesses antitumor activity and is chemically related to adriamycin and daunorubicin. The toxic effects of carminomycin observed in single-dose toxicologic studies in mice iv (4.5-13.5 mg2) and po (18.9-52.2 mg/m2), rats iv (6.0-21.0 mg/m2), dogs iv (1.0-16.0 mg/m2) and po (16.0-
R A, Buroker, D F, Johnson, H, Madissoo
openaire   +2 more sources

Interaction between antibiotics and antineoplastic drugs on antibacterial activity in-vitro - estramustine phosphate sensitizes pneumococci to amikacin.

International Journal of Oncology, 1994
The antibacterial and interactive effects of doxorubicin, cisplatin, cytarabine, vincristine, carmustine, mitoxantrone, methotrexate, bleomycin, 5-fluorouracil, epirubicin, DTIC, mitomycin, etoposide and estramustine phosphate on the antibacterial ...
P. Bergstrom, S. Holm, K. Grankvist, R. Henriksson   +3 more
semanticscholar   +1 more source

Compatibility of antineoplastic, antibiotic and corticosteroid drugs in intravenous admixtures

American Journal of Health-System Pharmacy, 1976
Through the use of absorption spectroscopy and visual observations, the compatibility of selected oncologic, antibiotic and corticosteroid drugs in intravenous admixtures was determined. The six drugs used in this study were methotrexate sodium, prednisolone sodium phosphate, sodium cephalothin, 5-fluorouracil, cytarabine and vincristine sulfate. These
James C. King, MP McRae
openaire   +3 more sources

ChemInform Abstract: FR901228: Antineoplastic Antibiotic

ChemInform, 1999
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
openaire   +3 more sources

Enzymatic release of nitric oxide from L-alanosine, an antineoplastic antibiotic

Biochemical and Biophysical Research Communications, 1982
Abstract L-Alanosine is an antineoplastic drug which is the 3-isonitramino analog of L -aspartic acid. The drug is known to be metabolized to the corresponding 2-oxo acid. Unlike the parent amino acid, the 2-oxo acid is unstable under mild conditions.
Theodore A. Alston, Harold J. Bright
openaire   +3 more sources

Daunomycin: A New Antibiotic with Antitumor Activity

Tumori Journal, 1963
Daunomycin is a new antibiotic isolated from cultures of Streptomyces peucetius. For its physicochemical characteristics it may belong to the group of antibiotics described by Ollis and Sutherland (11). The toxico-pharmacologic studies of Daunomycin administered i.v. to mice and rats indicated an acute LD50 value of 15-20 mg/kg.
Gaetani M, Dorigotti L, Dimarco A, M Soldati, Bellini O   +4 more
openaire   +4 more sources

Preliminary Pharmacokinetics of Streptozotocin, an Antineoplastic Antibiotic

The Journal of Clinical Pharmacology, 1977
A. J. Weiss, R. W. Manthei, A. B. Adolphe, W. M. Troetel, E. D. Glasofer   +4 more
openaire   +3 more sources