Results 81 to 90 of about 22,504 (303)
Advanced Science, EarlyView.Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang +6 more
wiley +1 more source
The cardiovascular system in patients with anthracycline cardiomiopathy
Бюллетень сибирской медицины, 2017 Aim. The purpose of this study was to examine the incidence of early and late cardiotoxicity in women receiving anthracycline antibiotics during breast cancer chemotherapy treatment as well as possible links of anthracycline-induced cardiomyopathy with ...
Alexandr T. Teplyakov +8 more
doaj +1 more source
Advanced Science, EarlyView.In summary, our study defines a coordinated oncogenic model in which NUDT21 integrates alternative polyadenylation–dependent UBE2D3 stabilization and transcriptional activation to sustain MYC‐driven T‐ALL cell survival, thereby establishing NUDT21 as a central regulatory node and a promising therapeutic target.
Conglian Qiu +18 more
wiley +1 more source
Investigations of Natural Products from Bryozoa Inhabiting Aotearoa New Zealand
, 2012 Two species of bryozoa, Pterocella vesiculosa and Plumatella repens, were investigated in an endeavour to isolate and characterise novel secondary metabolites.
Andersen, Aaron John Christian
core
Advanced Science, EarlyView.This study presents a 3D embedded bioprinting platform that recapitulates key stromal features of the tumor microenvironment using fibroblasts and lung‐derived ECM. The model enables functional assessment of CAR‐NK cells and provides a versatile tool to support the development of next‐generation immunotherapeutic strategies against solid tumors ...
Dahong Kim +10 more
wiley +1 more source
Advanced Science, EarlyView.In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo +8 more
wiley +1 more source
Frontiers in NeurologyMechanosensory hair cells of the inner ears and lateral line of vertebrates display heightened vulnerability to environmental insult, with damage resulting in hearing and balance disorders.
Patricia Wu +14 more
doaj +1 more source
Possible Potentiation of an Antitumor Agent by the Polyene Antibiotics
, 1974 v, 31 p.The hematologic neoplasms, which comprise the acute and chronic leukemias, myelomas and lymphomas, are responsible for 10% of all cancer deaths in adults and 50% of the cancer deaths in children.
Evans, Mark J.
core
PATTERN OF SUSPECTED ADVERSE DRUG REACTIONS IN A TERTIARY CARE HOSPITAL – A CROSS-SECTIONAL STUDY
, 2021 Objective: The objective of the study was to study the pattern of suspected adverse drug reactions (ADRs) in a tertiary care hospital. Methods: This is a cross-sectional study conducted in the Department of Pharmacology of a Tertiary Care Teaching ...
KORUTHARA MOHANAN, LIMA +2 more
core
Advanced Science, EarlyView.Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong +24 more
wiley +1 more source