Results 241 to 250 of about 1,625,451 (291)

Real-world use of Serial Clinical Observation in culture-proven early-onset sepsis: timing of recognition, treatment and retrospective comparison with the Neonatal Sepsis Calculator. [PDF]

Eur J Pediatr
Miselli F, Lugli L, Dragone G, Bedetti L, Spinedi S, Capretti M, Marrozzini L, Di Luca L, Fanaro S, Gambini L, Biasucci G, Piccinini G, Scarponi D, Papa I, Nanni F, Baroni L, Pagano R, Capone V, Berardi A.   +18 more
europepmc   +1 more source

Microglia Mitochondria Support Neuronal Maturation via Metabolic and Transcriptional Reprogramming in Human 3D In Vitro Brain Model

Advanced Science, EarlyView.
xx xx. ABSTRACT Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by disrupted neuronal circuit maturation. Emerging evidence implicates microglial function and mitochondrial regulation as contributors to ASD‐associated biology, yet the mechanisms linking these processes to neuronal development remain poorly defined ...
Sydney P. Sterben, Charitha C. Anamala, Sahan B. S. Kansakar, Vaishnavi Koduri, Volha Liaudanskaya   +4 more
wiley   +1 more source

"Miss, I want itchy medicine": Understanding what, why, and how antibiotics are used in Central Java province, Indonesia through the drug bag method. [PDF]

PLOS Glob Public Health
Naing SY, Schneiders ML, Ningrum D, Nurdianti T, Severin J, Peeters Grietens K, Wagenaar JA, Karuniawati A.   +7 more
europepmc   +1 more source

A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase

Advanced Science, EarlyView.
Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol, Lihi Gur‐Arie, Netanel Tzarum, Tamara Wellins, Naama Katsowich, Miriam Ravins, Michal Bejerano‐Sagie, Klil Cohen, Oded Livnah, Joshua N. Adkins, Ernesto Nakayasu, Alexei Savchenko, Yeu Khai Choong, Nikhil Kumar Tulsian, Saturo Machida, Sigal Ben‐Yehuda, Yael Litvak, J. Sivaraman, Ilan Rosenshine   +18 more
wiley   +1 more source

Garrod lecture: achieving the UNGA AMR mortality reduction goals. [PDF]

J Antimicrob Chemother
Laxminarayan R.
europepmc   +1 more source

Detection of Protein–Protein Interactions in Escherichia coli With Single Molecule Sensitivity

Advanced Science, EarlyView.
This article describes a regulatory circuit in Escherichia coli able to detect protein–protein interactions with exquisite sensitivity. The interaction between two hybrid proteins fused to Bordetella pertussis adenylate cyclase and its activator calmodulin triggers a potent cyclic AMP signaling cascade.
Marilyne Davi, Daniel Ladant
wiley   +1 more source

Association between Broad-Spectrum Antibiotic Use and Risk of Early-Onset Colorectal Cancer. [PDF]

Cancer Epidemiol Biomarkers Prev
Chao CR, Xu L, Wu BU, Figueiredo JC, Getahun D, Cannavale KL, Gilfillan AD, Chubak J.   +7 more
europepmc   +1 more source

Antibiotic self-medication behaviours and contributing factors among adults in the Southern West Bank, Palestine. [PDF]

JAC Antimicrob Resist
Qtait M, Farajalla F, Alqaissi N, Awwad K, Amro N, Jaradat Y.   +5 more
europepmc   +1 more source

Enhanced In Vitro Stability of Bedaquiline with Ascorbic Acid and Pyruvate During Long-Term Incubation in <i>Mycobacterium</i> Species. [PDF]

Antibiotics (Basel)
Batista S, Lamata J, Feliu L, Planas M, Fernandez-Pittol M, Martinez D, San Nicolás L, Tudó G, Gonzalez-Martin J.   +8 more
europepmc   +1 more source