Results 51 to 60 of about 674,963 (207)

Patients with Chronic Inflammatory Diseases Can Experience Higher Exposure of Small Molecule Drugs than Healthy Volunteers: An Analysis of Recently Approved Drugs

Clinical Pharmacology &Therapeutics, EarlyView.
Chronic inflammation has long been known to downregulate the activity of certain cytochrome P450 (CYP) enzymes—the main enzymes responsible for the phase I metabolism of many small molecule drugs—potentially leading to higher exposures in patients with chronic inflammatory diseases compared to healthy volunteers. Neglecting this potential difference in
Johannes Tillil, Sathej Gopalakrishnan, Jennifer Dong, Karthik Venkatakrishnan, Charlotte Kloft, Wilhelm Huisinga, Lena Klopp‐Schulze   +6 more
wiley   +1 more source

Pediatric Inflammatory Bowel Disease with Cytoplasmic Staining of Antineutrophil Cytoplasmic Antibodies

Clinical and Developmental Immunology, 2013
Background. It is unusual for the antineutrophil cytoplasmic antibody with cytoplasmic pattern (cANCA) to present in patients with inflammatory bowel disease (IBD) without vasculitis.
Omar I. Saadah, Jamil A. Al-Mughales
doaj   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

Complement blockade in the management of antineutrophil cytoplasmic antibodyassociated vasculitis

Spanish Journal of Medicine, 2022
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) are characterized by the presence of ANCA, particularly those directed against proteinase 3 (PR3) or myeloperoxidase (MPO).
José Salvador García-Morillo, Ricardo Blanco-Alonso, Enrique Morales-Ruiz   +2 more
doaj   +1 more source

ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES LEVELS IN THE PATIENTS WITH FAMILIAL MEDITERRANEAN FEVER DURING ACUTE ATTACK

Eurasian Journal of Medicine, 2019
Antineutrophil cytoplasmic antibodies (ANCA) are autoantibodies directed at lysosomal constituens of leucocytes, with two major immunufluoresence stainig patterns: cytoplasmic (c-ANCA), and perinuclear (p-ANCA).
Ali Rıza Odabaş, Ramazan Çetinkaya, Yılmaz Selçuk   +2 more
doaj  

Granulomatosis with Polyangiitis Misdiagnosed as IgA Vasculitis in a Child

Case Reports in Pediatrics, 2023
Background. Granulomatosis with polyangiitis (GPA) with early manifestations simulating IgA vasculitis is a very rare childhood systemic disease. Case Presentation.
Sheida Amini, Mohsen Jari
doaj   +1 more source

Diagnostic Delay in Eosinophilic Granulomatosis With Polyangiitis: Clinical Predictors and Implications for Earlier Recognition

Allergy, EarlyView.
This study aimed to assess diagnostic delay among patients with eosinophilic granulomatosis with polyangiitis (EGPA) and identify clinical characteristics associated with delayed recognition. EGPA diagnosis was delayed by nearly five years from symptom onset in this single‐center cohort.
Vani Mulkareddy, Kalena Liu, Shreya Mandloi, Kelsey Limage, Samuel R. Shing, Gurston G. Nyquist, Jessica Most, David Kennedy, Elina Toskala, Damaris Pena‐Evertz   +9 more
wiley   +1 more source

Antineutrophil cytoplasmic antibodies in inflammatory bowel disease: Clinical role and review of the literature

, 2000
PURPOSE: Perinuclear antineutrophil cytoplasmic antibodies have been found consistently in patients with ulcerative colitis; however, their pathogenetic and clinical role is still uncertain.
Lombardi G., Andriulli A., Piepoli A., Perri F., Bovio P., Annese V., Latiano A., Napolitano G., Conoscitore P.   +8 more
core   +1 more source

Concomitant cryoglobulinaemic vasculitis alongside ANCA-associated vasculitis: concurrence or coincidental individual occurrence [PDF]

The Korean Journal of Internal Medicine
Background/Aims Cryoglobulinaemic vasculitis (CryoVas) and antineutrophil cytoplasmic antibody-associated vasculitis (AAV) share the common characteristic of being small vessel vasculitides but exhibit significant differences in pathologic findings. This
Jeong Yeop Whang, Jang Woo Ha, Jihye Chung, Yong-Beom Park, Jaewoo Song, Younhee Park, Sang-Won Lee   +6 more
doaj   +1 more source

A De Novo ATP1A3 p.Arg995His Variant in a Patient With an Adult‐Onset Primary Lateral Sclerosis‐Like Syndrome

Clinical Genetics, EarlyView.
A 43‐year‐old woman developed a progressive adult‐onset upper motor neuron syndrome fulfilling the clinical criteria for primary lateral sclerosis (PLS), with mild cerebellar involvement. Genetic testing identified a de novo ATP1A3 p.Arg995His variant affecting a highly conserved residue within the transmembrane M8 domain.
Pablo Hernandez‐Vitorique, Marta García de Burgos, Ana Campos Villegas, María José Gómez Heredia, Pilar Carbonell Corvillo   +4 more
wiley   +1 more source