Drug-like analogues of the parasitic worm-derived immunomodulator ES-62 are therapeutic in the MRL/Lpr model of systemic lupus erythematosus [PDF]
, 2015 Introduction ES-62, a phosphorylcholine (PC)-containing immunomodulator secreted by the parasitic worm Acanthocheilonema viteae, protects against nephritis in the MRL/Lpr mouse model of systemic lupus erythematosus (SLE).
Harnett, M. M. +4 more
core +1 more source
BMC Rheumatology, 2023 Background Antinuclear antibodies (ANA) are antibodies present in several autoimmune disorders. However, a large proportion of the general population (20%) also have a positive test; very few of these individuals will develop an autoimmune disease, and ...
Jacy T. Zanussi +8 more
doaj +1 more source
Autoimmune diseases and their manifestations on oral cavity: diagnosis and clinical management [PDF]
, 2018 Oral signs are frequently the first manifestation of autoimmune diseases. For this reason, dentists play an important role in the detection of emerging autoimmune pathologies.
Bossù, Maurizio +5 more
core +2 more sources
Diagnostic Pathology, 2009 It has been more than 50 years since antinuclear antibodies were first discovered and found to be associated with connective tissue diseases. Since then different methods have been described and used for their detection or confirmation.
Minz Ranjana +2 more
doaj +1 more source
Immunology markers that can be predictive for the diagnosis of juvenile idiopathic arthritis
Journal of Laboratory Medicine, 2020 This study aimed to investigate the implications of antinuclear antibodies (ANAs) in juvenile idiopathic arthritis (JIA), the association with uveitis and the favorable evolution of the disease.
Sur Lucia M. +9 more
doaj +1 more source
Negative association of the chemokine receptor CCR5 d32 polymorphism with systemic inflammatory response, extra-articular symptoms and joint erosion in rheumatoid arthritis [PDF]
, 2009 Introduction Chemokines and their receptors control immune cell migration during infections as well as in autoimmune responses. A 32 bp deletion in the gene of the chemokine receptor CCR5 confers protection against HIV infection, but has also been ...
Arnold, Sybille +6 more
core +2 more sources
Autoantibody profiles and their association with blood eosinophils in asthma and COPD
Allergology International, 2017 Background: Autoimmune involvement in the pathogenesis of asthma and chronic obstructive pulmonary disease (COPD) has been proposed, and autoantibodies are a hallmark of autoimmunity.
Koji Tamai +10 more
doaj +1 more source
Antinuclear antibody profiling in uveitis [PDF]
Acta Ophthalmologica, 2018 _Editor,_ Antinuclear antibodies (ANA) are antibodies directed against a variety of nuclear antigens and are detected in patients with autoimmune diseases. Antinuclear antibodies (ANA) profiling is relevant for diagnostic purposes in various diseases, including systemic lupus erythematosus (SLE), Sj€ogren syndrome and systemic sclerosis (Smeenk et ...
Josianne C. ten Berge +3 more
openaire +4 more sources
Clinical and serological features of systemic sclerosis in a multicenter African American cohort: Analysis of the genome research in African American scleroderma patients clinical database. [PDF]
, 2017 Racial differences exist in the severity of systemic sclerosis (SSc). To enhance our knowledge about SSc in African Americans, we established a comprehensive clinical database from the largest multicenter cohort of African American SSc patients assembled
Boin, Francesco +28 more
core +1 more source
Antinuclear antibodies in systemic sclerosis associated with increased risk of malignancy
Przegląd Dermatologiczny, 2018 Patients with systemic sclerosis are at 1.5–5-fold increased risk of developing malignant diseases. It has been shown that some types of antinuclear antibodies associated with systemic sclerosis may have predictive value for development of malignant ...
Anna Stochmal +3 more
doaj +1 more source