Results 181 to 190 of about 513,078 (230)
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Antiphospholipid antibodies and antiphospholipid syndrome
Current Opinion in Rheumatology, 1995More than a decade has gone by since the detailed clinical description of antiphospholipid syndrome (APS). Thrombosis, the main complication of the syndrome, can affect vessels of all sizes; the consistent histopathologic lesion is a bland thrombus without inflammation.
M A, Khamashta, G R, Hughes
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The Clinical Significance of Antiphospholipid Antibodies
Annals of Medicine, 1997 The antiphospholipid syndrome is defined as the association between the presence of antiphospholipid antibodies, detected as anticardiolipin antibodies and/or lupus anticoagulant, and a history of either arterial or venous thrombosis and/or recurrent ...
Alberto Martini, Angelo Ravelli
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Antiphospholipid Antibodies and Reproduction: The Antiphospholipid Antibody Syndrome
American Journal of Reproductive Immunology, 1999In women who have a diagnosis of APS (both clinical and laboratory criteria) the chance for successful pregnancy is reduced. In these cases, treatment appears to be a clear option, particularly in the case of prior thromboembolic events. The current preference of treatment for women with RPL and aPL antibodies is subcutaneous heparin and aspirin.
W H, Kutteh, N S, Rote, R, Silver
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Antiphospholipid antibody and antiphospholipid antibody syndrome
Current Opinion in Rheumatology, 1991New details have been added to the description of the antiphospholipid antibody syndrome. These include quantitation of risk of stroke; delineation of an associated acute occlusive vasculopathy syndrome, including its pathology; increased awareness of the association of adrenal insufficiency with antiphospholipid antibody; new demonstration of ...
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ANTIPHOSPHOLIPID ANTIBODIES AND THE ENDOTHELIUM
Rheumatic Disease Clinics of North America, 2001The interaction between aPL (particularly anti-beta 2GPI antibodies) and endothelium does represent a potential pathogenetic mechanism for the thrombotic manifestations of the syndrome. The autoantibody-mediated EC activation probably plays a role in sustaining the appearance of a proadhesive, proinflammatory, and procoagulant phenotype.
P. L. Meroni +4 more
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Antiphospholipid antibodies and the antiphospholipid antibody syndrome
Journal of the American Academy of Dermatology, 1997The antiphospholipid antibody syndrome is a multiple-system disorder characterized by persistently elevated antiphospholipid antibodies and/or arterial or venous thrombosis, thrombocytopenia, or recurrent spontaneous abortion. Anticardiolipin antibodies and the lupus anticoagulant are different classes of antiphospholipid antibodies associated with ...
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Antiphospholipid syndrome, antiphospholipid antibodies, and atherosclerosis
Current Atherosclerosis Reports, 2001The antiphospholipid syndrome is characterized by arterial and venous thrombosis, as well as pregnancy morbidity, in the presence of elevated levels of antiphospholipid antibodies. These autoantibodies have procoagulant activity, as they affect platelets, humoral coagulation factors, and endothelial cells.
Y, Sherer, Y, Shoenfeld
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Atherogenic Antiphospholipid Antibodies in Antiphospholipid Syndrome
Annals of the New York Academy of Sciences, 2007Abstract: Macrophage uptake of oxidized LDL (oxLDL) plays a critical role in early stages of atherosclerosis. We previously reported that oxLDL forms stable complexes with β2‐glycoprotein I (β2GPI), and that these complexes were frequently present in the sera of patients with systemic lupus erythematosus (SLE) and/or antiphospholipid syndrome (APS ...
Kazuko, Kobayashi +2 more
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Antiphospholipid antibody syndrome
Current Opinion in Ophthalmology, 2012Antiphospholipid syndrome is a rare cause of ocular vaso-occlusive disease, but is associated with significant systemic morbidity and mortality. Thus, early diagnosis and treatment is essential.Although the pathophysiology of antiphospholipid syndrome continues to be poorly understood, there has been continued progress with regard to the relationship ...
Paul, Yang +2 more
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Atherosclerosis, Antiphospholipid Syndrome, and Antiphospholipid Antibodies
Frontiers in Bioscience, 2007In antiphospholipid syndrome (APS) patients, some antiphospholipid antibodies (APA) are directed against negatively-charged phospholipids, while other APA are specific for phospholipid-proteins such as beta2-glycoprotein I (beta2GPI). Increased levels of oxidized low density lipoproteins (oxLDL) are present in atherosclerosis patients and these ...
Danielle, Nicolo +2 more
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