Results 191 to 200 of about 554,110 (237)
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Atherogenic Antiphospholipid Antibodies in Antiphospholipid Syndrome
Annals of the New York Academy of Sciences, 2007Abstract: Macrophage uptake of oxidized LDL (oxLDL) plays a critical role in early stages of atherosclerosis. We previously reported that oxLDL forms stable complexes with β2‐glycoprotein I (β2GPI), and that these complexes were frequently present in the sera of patients with systemic lupus erythematosus (SLE) and/or antiphospholipid syndrome (APS ...
Kazuko, Kobayashi +2 more
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Antiphospholipid antibody syndrome
Current Opinion in Ophthalmology, 2012Antiphospholipid syndrome is a rare cause of ocular vaso-occlusive disease, but is associated with significant systemic morbidity and mortality. Thus, early diagnosis and treatment is essential.Although the pathophysiology of antiphospholipid syndrome continues to be poorly understood, there has been continued progress with regard to the relationship ...
Paul, Yang +2 more
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Atherosclerosis, Antiphospholipid Syndrome, and Antiphospholipid Antibodies
Frontiers in Bioscience, 2007In antiphospholipid syndrome (APS) patients, some antiphospholipid antibodies (APA) are directed against negatively-charged phospholipids, while other APA are specific for phospholipid-proteins such as beta2-glycoprotein I (beta2GPI). Increased levels of oxidized low density lipoproteins (oxLDL) are present in atherosclerosis patients and these ...
Danielle, Nicolo +2 more
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Antiphospholipid Antibodies and Reproduction
American Journal of Reproductive Immunology, 1989ABSTRACT: Antiphospholipid antibodies (APAs) may be identified in the laboratory by using either coagulation studies or solid‐phase immunologic assays (ELISA; RIA). These methodologies do not necessarily evaluate the same antibody; consequently, it is appropriate to screen a patient's plasma by utilizing both assays.
D A, Triplett, E N, Harris
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Antiphospholipid antibodies and atherosclerosis
Lupus, 1998β2-Glycoprotein I (β2-GPI) is a major antigen for anticardiolipin antibodies (aCL) induced in patients with antiphospholipid syndrome and their antigenic epitopes are cryptic. The epitopes appear on the surface of β2-GPI molecule only when β2-GPI interacts with lipid membranes containing negatively charged phospholipids or polyoxygenated polystyrene ...
E, Matsuura +3 more
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Antiphospholipid antibodies and pregnancy
Best Practice & Research Clinical Haematology, 2003Antiphospholipid antibodies, i.e. lupus anticoagulants and anticardiolipin antibodies, are associated with obstetric complications. Fetal death and recurrent spontaneous abortions represent the obstetric criteria of the antiphospholipid syndrome. They occur with similar frequences and have an overall prevalence of 15-20%.
Monica, Galli, Tiziano, Barbui
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ANTIPHOSPHOLIPID ANTIBODY SYNDROME
Rheumatic Disease Clinics of North America, 1992The antiphospholipid syndrome is now well recognized and is separable from SLE, but better quantitation of both the clinical elements and the serologic definitions is still needed. It is likely for autoimmune but not for infection-induced aPL that the antigen is not phospholipid itself but a complex formed by phospholipid and beta 2 glycoprotein I ...
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Antiphospholipid antibodies and infertility
Human Fertility, 2002Antiphospholipid antibodies (aPL) are an established cause of recurrent pregnancy loss. As defective embryonic implantation is a common link between unexplained infertility and recurrent miscarriage, interest has focused on the potential relationship between aPL and implantation failure after in vitro fertilization and embryo transfer (IVF-ET).
May, Backos, Raj, Rai, Lesley, Regan
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Antiphospholipid antibodies and the endothelium
Current Rheumatology Reports, 2000This article reviews current understanding of the relationship between antiphospholipid antibodies and the endothelium. In vitro antiphospholipid antibodies produce endothelial cell activation. Clinical data in this area are scanty and worthy of future research, which could lead to new therapies in the management of antiphospholipid syndrome.
B J, Hunt, M A, Khamashta
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Antiphospholipid antibody syndrome
Current Treatment Options in Cardiovascular Medicine, 2003Antiphospholipid antibody syndrome (APS) is a recently defined autoimmune disorder characterized by recurrent vascular thromboses or recurrent pregnancy morbidity; these features are linked to the presence in blood of autoantibodies against negatively charged phospholipids or phospholipid-binding proteins.
Elena, Cucurull +3 more
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