Results 211 to 220 of about 27,764 (256)
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Antiphospholipid syndrome, antiphospholipid antibodies, and atherosclerosis
Current Atherosclerosis Reports, 2001The antiphospholipid syndrome is characterized by arterial and venous thrombosis, as well as pregnancy morbidity, in the presence of elevated levels of antiphospholipid antibodies. These autoantibodies have procoagulant activity, as they affect platelets, humoral coagulation factors, and endothelial cells.
Y, Sherer, Y, Shoenfeld
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Atherogenic Antiphospholipid Antibodies in Antiphospholipid Syndrome
Annals of the New York Academy of Sciences, 2007Abstract: Macrophage uptake of oxidized LDL (oxLDL) plays a critical role in early stages of atherosclerosis. We previously reported that oxLDL forms stable complexes with β2‐glycoprotein I (β2GPI), and that these complexes were frequently present in the sera of patients with systemic lupus erythematosus (SLE) and/or antiphospholipid syndrome (APS ...
Kazuko, Kobayashi +2 more
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Antiphospholipid antibody syndrome
Current Opinion in Ophthalmology, 2012Antiphospholipid syndrome is a rare cause of ocular vaso-occlusive disease, but is associated with significant systemic morbidity and mortality. Thus, early diagnosis and treatment is essential.Although the pathophysiology of antiphospholipid syndrome continues to be poorly understood, there has been continued progress with regard to the relationship ...
Paul, Yang +2 more
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Atherosclerosis, Antiphospholipid Syndrome, and Antiphospholipid Antibodies
Frontiers in Bioscience, 2007In antiphospholipid syndrome (APS) patients, some antiphospholipid antibodies (APA) are directed against negatively-charged phospholipids, while other APA are specific for phospholipid-proteins such as beta2-glycoprotein I (beta2GPI). Increased levels of oxidized low density lipoproteins (oxLDL) are present in atherosclerosis patients and these ...
Danielle, Nicolo +2 more
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Antiphospholipid antibodies and infertility
Human Fertility, 2002Antiphospholipid antibodies (aPL) are an established cause of recurrent pregnancy loss. As defective embryonic implantation is a common link between unexplained infertility and recurrent miscarriage, interest has focused on the potential relationship between aPL and implantation failure after in vitro fertilization and embryo transfer (IVF-ET).
May, Backos, Raj, Rai, Lesley, Regan
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ANTIPHOSPHOLIPID ANTIBODY SYNDROME
Rheumatic Disease Clinics of North America, 1992The antiphospholipid syndrome is now well recognized and is separable from SLE, but better quantitation of both the clinical elements and the serologic definitions is still needed. It is likely for autoimmune but not for infection-induced aPL that the antigen is not phospholipid itself but a complex formed by phospholipid and beta 2 glycoprotein I ...
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Antiphospholipid antibodies and the endothelium
Current Rheumatology Reports, 2000This article reviews current understanding of the relationship between antiphospholipid antibodies and the endothelium. In vitro antiphospholipid antibodies produce endothelial cell activation. Clinical data in this area are scanty and worthy of future research, which could lead to new therapies in the management of antiphospholipid syndrome.
B J, Hunt, M A, Khamashta
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Antiphospholipid antibody syndrome
Current Treatment Options in Cardiovascular Medicine, 2003Antiphospholipid antibody syndrome (APS) is a recently defined autoimmune disorder characterized by recurrent vascular thromboses or recurrent pregnancy morbidity; these features are linked to the presence in blood of autoantibodies against negatively charged phospholipids or phospholipid-binding proteins.
Elena, Cucurull +3 more
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Pediatric Antiphospholipid Antibodies and Antiphospholipid Syndrome
Seminars in Thrombosis and Hemostasis, 2008Antiphospholipid syndrome (APS) can occur in children, like adults, with the same diverse spectrum of thrombotic sites but predominately with deep vein thrombosis and stroke. In contrast with adults, however, transient nonthrombogenic antiphospholipid (aPL) antibodies are seen more commonly, usually after childhood infections.
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Antiphospholipid Antibodies and Reproduction
American Journal of Reproductive Immunology, 1989ABSTRACT: Antiphospholipid antibodies (APAs) may be identified in the laboratory by using either coagulation studies or solid‐phase immunologic assays (ELISA; RIA). These methodologies do not necessarily evaluate the same antibody; consequently, it is appropriate to screen a patient's plasma by utilizing both assays.
D A, Triplett, E N, Harris
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