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Antiphospholipid antibodies and pregnancy
Best Practice & Research Clinical Haematology, 2003Antiphospholipid antibodies, i.e. lupus anticoagulants and anticardiolipin antibodies, are associated with obstetric complications. Fetal death and recurrent spontaneous abortions represent the obstetric criteria of the antiphospholipid syndrome. They occur with similar frequences and have an overall prevalence of 15-20%.
Monica, Galli, Tiziano, Barbui
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Antiphospholipid Antibodies in Migraine
Headache: The Journal of Head and Face Pain, 1991SYNOPSIS We studied the presence of serum antiphospholipid antibodies (APA) in 35 patients with migraine and 75 controls. None of the controls showed APA, while we found these antibodies in five patients out of the 35 studied (p=0.003). The clinical features of migraineurs with APA were similar to those of patients without them. After
C, Iñiguez +4 more
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Antiphospholipid Antibody Syndrome
Obstetrics and Gynecology Clinics of North America, 2014Antiphospholipid antibodies (aPLs) are acquired antibodies directed against negatively charged phospholipids. Obstetric antiphospholipid antibody syndrome (APS) is diagnosed in the presence of certain clinical features in conjunction with positive laboratory findings.
William H, Kutteh, Candace D, Hinote
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Antiphospholipid antibody syndrome
Current Treatment Options in Neurology, 2000When the diagnosis of antiphospholipid antibody syndrome (aPS) is being considered in persons who have experienced an ischemic stroke or a transient ischemic attack, it is important to gauge how well the history and laboratory data fit with this diagnosis as opposed to other causes of infarct.
, Jacobs, , Levine
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Antiphospholipid antibodies and stroke
Current Cardiology Reports, 2004Antiphospholipid antibodies are associated with venous and arterial thrombo-occlusive events, including stroke. They are a heterogeneous family of antibodies that react to negatively charged membrane-bound phospholipids or phospholipid-protein complexes.
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JCR: Journal of Clinical Rheumatology, 1997
Although significant progress has been made during the last decade in our knowledge of the antiphospholipid antibodies (aPL), there are two major questions in clinical practice that require further guidelines: Indications for aPL determination and laboratory tests to choose. This article reviews the main clinical indications to search for aPL (systemic
R, Cervera, J, Font, R A, Asherson
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Although significant progress has been made during the last decade in our knowledge of the antiphospholipid antibodies (aPL), there are two major questions in clinical practice that require further guidelines: Indications for aPL determination and laboratory tests to choose. This article reviews the main clinical indications to search for aPL (systemic
R, Cervera, J, Font, R A, Asherson
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Antiphospholipid Antibodies in Children
Seminars in Thrombosis and Hemostasis, 1998Lupus anticoagulant (LA) is made up of heterogeneous IgG and IgM antibodies that prolong clotting times in vitro and is associated with an increased rate of both thrombosis and hemorrhage in vivo, although thrombosis is far more common. Many mechanisms of action have been explored, but none explains the coagulation abnormality of every sample tested ...
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Antiphospholipid antibodies and reproduction
Journal of Reproductive Immunology, 1997The antiphospholipid antibodies (APA) are acquired antibodies against a phospholipid which has been associated with slow progressive thrombosis and infarction in the placenta. Clinical features (venous or arterial thrombosis, recurrent fetal loss, thrombocytopenia) in conjunction with positive laboratory findings (positive IgG or IgM anticardiolipin ...
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Antiphospholipid antibodies and atherosclerosis
Lupus, 1998β2-Glycoprotein I (β2-GPI) is a major antigen for anticardiolipin antibodies (aCL) induced in patients with antiphospholipid syndrome and their antigenic epitopes are cryptic. The epitopes appear on the surface of β2-GPI molecule only when β2-GPI interacts with lipid membranes containing negatively charged phospholipids or polyoxygenated polystyrene ...
E, Matsuura +3 more
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Antiphospholipid antibody and antiphospholipid antibody syndrome.
Current opinion in rheumatology, 1992Over the past year, many reports have been published on a variety of clinical manifestations related to antiphospholipid antibodies. The low prevalence of anticardiolipin antibodies with the rare occurrence of thrombosis and a low rate of fetal loss in studies in Malaysia and China showed a potential role for local factors.
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