Results 91 to 100 of about 621,927 (266)

Combinatorial Synthesis of Next Generation Water‐Soluble Quaternized N‐Halamine Oligomers with Long‐Lasting Antiviral Properties

Advanced Functional Materials, EarlyView.
A combinatorial library of dual‐functional antiviral oligomers incorporating N‐halamine and quaternary ammonium functionalities is developed for long‐lasting antiviral activity. The lead materials exhibit rapid and durable antiviral activity against SARS‐CoV‐2 variants and influenza H1N1, with 4 to 5 log reduction in viral copies at 5 mg mL−1 ...
Eid Nassar‐Marjiya, Konda Reddy Kunduru, Krishanu Ghosal, Luna Rizik, Nofar Atari, Mahran Daifa, Neta Kutner, Bassma Khamaisi, Qi Wu, Simran Jindal, Merna Shaheen‐Mualim, Ranabir Majumder, Mahitosh Mandal, Michal Mandelboim, Shady Farah   +14 more
wiley   +1 more source

Identification of a novel mechanism of action of bovine IgG antibodies specific for Staphylococcus aureus

Veterinary Research, 2018
Staphylococcus aureus is a major pathogen that causes subclinical mastitis associated with huge economic losses to the dairy industry. A few vaccines for bovine mastitis are available, and they are expected to induce the production of S.
Mutsumi Furukawa, Hiroshi Yoneyama, Eiji Hata, Hidetomo Iwano, Hidetoshi Higuchi, Tasuke Ando, Mika Sato, Tomohito Hayashi, Yoshio Kiku, Yuya Nagasawa, Kanae Niimi, Katsuki Usami, Kumiko Ito, Kouichi Watanabe, Tomonori Nochi, Hisashi Aso   +15 more
doaj   +1 more source

Validation of an automated enzyme immunoassay for interleukin-6 for routine clinical use [PDF]

, 1998
Serum levels of Interleukin-6 (IL-6), a proinflammatory cytokine, are increased in early stages of inflammatory diseases such as infection and sepsis. Assay systems which permit its measurement within a few hours and as a single measurement have not been
Cremer, Peter, Dehart, Isabelle, Fraunberger, Peter, Holler, Ernst, Nagel, Dorothea, Pfeiffer, Matthias, Seidel, Dietrich, Thein, Michael, Walli, Autar K.   +8 more
core   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Dissecting the properties of circulating IgG against streptococcal pathogens through a combined systems antigenomics-serology workflow

Nature Communications
This study showcases an integrative mass spectrometry-based strategy combining systems antigenomics and systems serology to characterize human antibodies in clinical samples.
Alejandro Gomez Toledo, Sounak Chowdhury, Elisabeth Hjortswang, James T. Sorrentino, Nathan E. Lewis, Anna Bläckberg, Simon Ekström, Sven Kjellström, Arman Izadi, Berit Olofsson, Pontus Nordenfelt, Lars Malmström, Magnus Rasmussen, Johan Malmström   +13 more
doaj   +1 more source

Identification of the YfgF MASE1 domain as a modulator of bacterial responses to aspartate [PDF]

, 2013
Complex 3'-5'-cyclic diguanylic acid (c-di-GMP) responsive regulatory networks that are modulated by the action of multiple diguanylate cyclases (DGC; GGDEF domain proteins) and phosphodiesterases (PDE; EAL domain proteins) have evolved in many bacteria.
Agasing, A., Green, J., Lacey, M., Lowry, R.   +3 more
core   +1 more source

Liquid Crystalline Inverted Lipid Phases and Reverse Micelles in Drug Delivery: From Molecular Design to Therapeutic Potential

Advanced Functional Materials, EarlyView.
Liquid crystalline inverted lipid phases and reverse micelles are self‐assembled lipid nanostructures that enhance the solubility, stability, and delivery of diverse therapeutics. This review integrates their physicochemical principles, formulation strategies, drug loading mechanisms, and biomedical applications, highlighting their growing ...
Numan Eczacioglu, Mulazim Hussain Asim, Soheil Haddadzadegan, Andreas Bernkop‐Schnürch   +3 more
wiley   +1 more source

Protocol for developing Pseudomonas aeruginosa type III secretion system-neutralizing monoclonal antibodies from human B cells

STAR Protocols
Summary: Monoclonal antibodies (mAbs) targeting bacterial virulence factors may represent promising therapeutics in the fight against severe bacterial infections. Here, we present an approach for developing human-derived antibodies targeting the type III
Alexandra Albus, Christoph Kreer, Florian Klein, Jan Rybniker, Alexander Simonis   +4 more
doaj   +1 more source

Characterization of the Interaction between the Herpes Simplex Virus Type I Fc Receptor and Immunoglobulin G [PDF]

, 1999
Herpes simplex virus type I (HSV-1) virions and HSV-1-infected cells bind to human immunoglobulin G (hIgG) via its Fc region. A complex of two surface glycoproteins encoded by HSV-1, gE and gI, is responsible for Fc binding.
Bjorkman, Pamela J., Chapman, Tara L., Joseph, Ian M., Morrison, Sherie L., Raghavan, Malini, You, Il   +5 more
core   +1 more source

An Ultrafast Self‐Gelling Versatile Hydrogel for Rapid Infected Burn Wound Repair in Military Medicine

Advanced Functional Materials, EarlyView.
A self‐gelling PG@PAC (POD/Gel‐CDH@PA/CHX) powder is developed for infected burn care in austere settings. Upon contact with wound exudate, it instantly forms an adhesive hydrogel, providing simultaneous hemostasis, broad‐spectrum antibacterial activity, reactive oxygen species scavenging, and immunomodulation. In a murine model of S.
Liping Zhang, Zhangrui Wu, Xiansheng Zhao, Geng Wang, Quyang Yang, Minxia zhang, Xiaowei Wang, Xiujun Cheng, Changyue Wu, Dan Wu, Yutian Yang, Canbin Dong, Tao Zhang, Weiqiang Tan, Ningwen Zhu   +14 more
wiley   +1 more source