Results 211 to 220 of about 3,053,812 (327)

Inhibition of RACK1‐Mediated NLRP3 Oligomerization (Active Conformation) Ameliorates Acute Respiratory Distress Syndrome

Advanced Science, EarlyView.
Schematic diagram showing the potential mechanism of bigelovin on the activation of NLRP3 inflammasome Bigelovin may inhibit activated protein C kinase 1 (RACK1) by directly binding with cys168 of RACK1. Bigelovin thus prevents oligomerization of NLRP3 (NLRP3 active conformation) and subsequent assembly of NLRP3 inflammasome, blocking the activation of
Jian Cui, Meng Yang, Chengli Yu, Haidong Zhang, Yuan Gong, Yang Hu, Yue Wang, Qingxin Yuan, An Pan, Jiepin Li, Yaowen Hu, Zecheng Jin, Xuemei Peng, Anyuan Wu, Junwei Wang, Qian Wang, Yinan Zhang, Lihong Hu   +17 more
wiley   +1 more source

Impact of Staphylococcus aureus colonization and skin abscesses on formation of human anti-αGal antibodies. [PDF]

Med Microbiol Immunol
Bernth Jensen JM, Dinh KM, Hindhede L, Erikstrup LT, Hansen AG, Hymøller KM, Ostrowski SR, Pedersen OBV, Christiansen SH, Sørensen UBS, Thiel S, Erikstrup C.   +11 more
europepmc   +1 more source

Microneedles at the Forefront of Next Generation Theranostics

Advanced Science, EarlyView.
The TOC figure illustrates the revolutionary role of microneedles in modern medicine, showcasing their dual diagnostic and therapeutic functions. On the left, microneedles access interstitial fluid for real‐time monitoring of biomarkers like glucose and hormones.
Chan Wang, Yuan Yang, Jiaqi Zhang, Hanrui Zhang, Qian Wang, Shengmei Ma, Pengfei Zhao, Zhou Li, Yuxin Liu   +8 more
wiley   +1 more source

Cytokines Meet Phages: A Revolutionary Pathway to Modulating Immunity and Microbial Balance. [PDF]

Biomedicines
Cianci R, Caldarelli M, Brani P, Bosi A, Ponti A, Giaroni C, Baj A.   +6 more
europepmc   +1 more source

Accurate Delivery of Mesenchymal Stem Cell Spheroids With Platelet‐Rich Fibrin Shield: Enhancing Survival and Repair Functions of Sp‐MSCs in Diabetic Wound Healing

Advanced Science, EarlyView.
Autologous plasma‐derived platelet‐rich fibrin (PRF) is prepared as a protective shield for mesenchymal stem cell spheroids (Sp‐MSCs). PRF forms a fibrin shield to protect Sp‐MSCs from the oxidative stress environment. The nutrients in PRF, particularly the α‐granules, can enhance the repair function of Sp‐MSCs.
Jinglve Zhang, Wenqing Xu, Yutian Xiao, Dingheng Su, Yusheng He, Huohong Yang, Yixin Xie, Xiaofang Wang, Ren‐He Xu, Shaorong Lei, Dingyu Wu   +10 more
wiley   +1 more source

Plastic Antibodies for the detection of Bacterial Proteins and Microorganisms

, 2016
The diagnosis of most illnesses is of vital importance for providing the appropriate cure and hence controlling public health concerns. The standard methods that are used to confirm the presence of microorganisms typically consist of specific enrichment media to multiply, separate, identify and count bacterial cells. The duration of the process depends
openaire   +3 more sources

Intranasal application of a bifunctional pertactin-RTX fusion antigen elicits protection of mouse airway mucosa against <i>Bordetella pertussis</i> colonization. [PDF]

mSphere
Espinosa-Vinals C, Holubova J, Stanek O, Osicka R, Masin J, Arellano Herencia FE, Sebo P.   +6 more
europepmc   +1 more source

Efficient and Specific PDGFRβ‐Targeting Dual‐Mode T1‐T2 MRI Nanoprobe for Early Diagnosis of Non‐Alcoholic Fatty Liver

Advanced Science, EarlyView.
The Fe3O4/Gd@BSA‐pPB nanoprobe leverages biomimetic mineralization and targets hepatic stellate cells (HSCs) through PDGFRβ, offering superior enrichment in fibrotic regions. This targeted delivery overcomes biological barriers, enhancing both the accuracy and sensitivity of MRI imaging at early disease stages.
Zehua Li, Tongwei Zhang, Tongxiang Tao, Yaxuan Liu, Haining Xia, Sajid ur Rehman, Zeyong Guo, Jing Zhang, Ruiguo Chen, Zhan Zhang, Junfeng Wang, Kun Ma   +11 more
wiley   +1 more source

Splenic red pulp macrophages eliminate the liver-resistant <i>Streptococcus pneumoniae</i> from the blood circulation of mice. [PDF]

Sci Adv
An H, Huang Y, Zhao Z, Li K, Meng J, Huang X, Tian X, Zhou H, Wu J, Dai Q, Zhang JR.   +10 more
europepmc   +1 more source

Isolation Techniques of Micro/Nano‐Scaled Species for Biomedical Applications

Advanced Science, EarlyView.
Separating micro/nano‐scale bioparticles from samples is essential for disease diagnosis, prevention, and monitoring. Therefore, a comprehensive overview of the latest advanced separation technologies is provided, and characteristics and limitations based on six key performance parameters, including purity, recovery rate, throughput, resolution, size ...
Qing Lu, Zhinan Zhang, Xianting Ding
wiley   +1 more source