Results 211 to 220 of about 387,972 (242)

Novel TLR2xTLR4 Bispecific Antibody Inhibits Bacterial Sepsis

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, 2021
Toll-like receptors (TLRs) sense microbial infection through recognition of pathogen-associated molecular patterns. For example, TLR4 responds to the lipopolysaccharide of gram-negative bacteria, whereas TLR2 recognizes a broad range of microbial ligands. Both receptors are, therefore, compelling targets for treating sepsis.
Masahito, Sato, Satoshi, Takeuchi, Ryuichi, Moriya, Takuya, Kito, Shinji, Soga, Koji, Aoyama, Jotaro, Suzuki   +6 more
openaire   +2 more sources

Anti-bacterial Monoclonal Antibodies

2017
The failing efficacy of antibiotics and the high mortality rate among high-risk patients calls for new treatment modalities for bacterial infections. Due to the vastly divergent pathogenesis of human pathogens, each microbe requires a tailored approach.
Eszter, Nagy, Gábor, Nagy, Christine A, Power, Adriana, Badarau, Valéria, Szijártó   +4 more
openaire   +2 more sources

Bacterial coloration immunofluorescence strip for ultrasensitive rapid detection of bacterial antibodies and targeted antibody-secreting hybridomas

Journal of Immunological Methods, 2022
The indirect enzyme-linked immunosorbent assay (ELISA) is the gold standard method for monoclonal antibody (McAb) detection and plays a unique role in the preparation of bacterial antibodies. To solve the laborious issues associated with indirect ELISA, a novel bacterial coloration immunofluorescence strip (BCIFS) for antibody detection using colored ...
Shuiqin, Fang, Hao, Yang, Cheng, Liu, Yachen, Tian, Meijiao, Wu, Youxue, Wu, Qing, Liu   +6 more
openaire   +2 more sources

BACTERIAL ANTIBODIES IN LIVER DISEASE

The Lancet, 1972
D M, Danks, R F, Bishop
  +9 more sources

Serum antibodies and bacterial meningitis

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1991
The role of serum antibodies in bacterial meningitis and the human defence against it is reviewed. There is good evidence from animal and human studies in vitro and in vivo showing that serum antibodies to the capsular polysaccharide of the bacteria play a major role in protection, whereas antibodies to other cell surface components vary in protective ...
openaire   +2 more sources

Enzymatic Antibody Modification by Bacterial Transglutaminase

2013
Enzymatic posttranslational modification of proteins permits more precise control over conjugation site than chemical modification of reactive amino acid side chains. Ideally, protein modification by an enzyme yields completely homogeneous conjugates with improved properties for research or therapeutic use. As an example, we here provide a protocol for
Patrick, Dennler, Roger, Schibli, Eliane, Fischer   +2 more
openaire   +2 more sources

BACTERIAL AND DIETARY ANTIBODIES IN LIVER DISEASE

The Lancet, 1972
Abstract A highly significant increase in antibody titres to Escherichia coli, Bacteroides , and rat-colon antigen is present in patients with liver disease, particularly chronic active hepatitis, when compared with controls; whereas antibody titres to Hœmophilus influenzœ are unremarkable. Serial sera from patients with acute viral hepatitis show
D R, Triger, M H, Alp, R, Wright
openaire   +2 more sources

Antibody affinity maturation using bacterial surface display

Protein Engineering Design and Selection, 1998
A quantitative system for screening combinatorial single-chain Fv (scFv) antibody libraries was developed utilizing surface display on Escherichia coli and fluorescence-activated cell sorting (FACS). This system was employed to isolate clones with high-affinity to a fluorescently-labeled hapten from libraries constructed by randomizing heavy and light ...
P S, Daugherty, G, Chen, M J, Olsen, B L, Iverson, G, Georgiou   +4 more
openaire   +2 more sources

Antibodies against some bacterial antigens in children

Acta Paediatrica, 1994
The prevalence of bacterial antibodies was determined in 173 children aged 0–15 years. The prevalence of IgG Borrelia burgdorferi antibodies in titres > 500 in children less than 8 years of age was 6% while none of the older children had these antibodies in titres > 400. IgG Helicobacter pylori antibodies were detected only in children older than
S, Kontiainen, I, Seppälä, A, Miettinen, T U, Kosunen, M, Verkasalo, J, Mäenpää   +5 more
openaire   +2 more sources

Monoclonal Antibodies Against Bacterial Outer Membrane Antigens

1985
Monoclonal antibodies have proved to be highly specific tools for defining the antigenic epitopes of Pseudomonas aeruginosa outer membrane macromolecules. In this article we have highlighted the use of monoclonal antibodies in the study of lipopolysaccharide heterogeneity and in particular have demonstrated that single monoclonal antibodies can ...
R E, Hancock, L M, Mutharia
openaire   +2 more sources