Results 41 to 50 of about 402,506 (263)

Human antibody repertoire frequently includes antibodies to a bacterial biofilm associated protein.

PLoS ONE, 2019
We have previously described a native human monoclonal antibody, TRL1068, that disrupts bacterial biofilms by extracting from the biofilm matrix key scaffolding proteins in the DNABII family, which are present in both gram positive and gram negative ...
Stefan Ryser, Edgar Tenorio, Angeles Estellés, Lawrence M Kauvar   +3 more
doaj   +1 more source

Recent Developments in Antibody-Based Assays for the Detection of Bacterial Toxins

Toxins, 2014
Considering the urgent demand for rapid and accurate determination of bacterial toxins and the recent promising developments in nanotechnology and microfluidics, this review summarizes new achievements of the past five years.
Kui Zhu, Richard Dietrich, Andrea Didier, Dominik Doyscher, Erwin Märtlbauer   +4 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

TIV Vaccination Modulates Host Responses to Influenza Virus Infection that Correlate with Protection against Bacterial Superinfection

Vaccines, 2019
Background: Influenza virus infection predisposes to secondary bacterial pneumonia. Currently licensed influenza vaccines aim at the induction of neutralizing antibodies and are less effective if the induction of neutralizing antibodies is low and/or the
Angela Choi, Ioanna Christopoulou, Xavier Saelens, Adolfo García-Sastre, Michael Schotsaert   +4 more
doaj   +1 more source

Functional assays to screen and select monoclonal antibodies that target Yersinia pestis

Human Vaccines & Immunotherapeutics, 2023
Yersinia pestis is a gram-negative bacterium that causes plague in animals and humans. Depending on the route of disease transmission, the bacterium can cause an acute, often fatal disease that has a narrow window for treatment with antibiotics ...
Sergei S. Biryukov, Nathaniel O. Rill, Christopher P. Klimko, Jennifer L. Dankmeyer, Jennifer L. Shoe, Melissa Hunter, Yuli Talyansky, Derrick Hau, Marcellene A. Gates-Hollingsworth, Sujata G. Pandit, David P. Fetterer, Ju Qiu, Michael L. Davies, David P. AuCoin, Christopher K. Cote   +14 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Anti-platelet factor 4/polyanion antibodies mediate a new mechanism of autoimmunity

Nature Communications, 2017
Antibodies against the platelet factor 4 (PF4) support bacterial host defence but in some cases may lead to heparin-induced thrombocytopenia (HIT).
Thi-Huong Nguyen, Nikolay Medvedev, Mihaela Delcea, Andreas Greinacher   +3 more
doaj   +1 more source

Monoclonal antibody-based therapies for bacterial infections [PDF]

Current Opinion in Infectious Diseases, 2019
Purpose of review This review highlights recent developments in the development of monoclonal antibodies to treat bacterial disease, including preclinical advances and the status of current clinical trials. Recent findings Monoclonal antibody (mAb) therapy is becoming increasingly ...
Michael P, Motley, Kasturi, Banerjee, Bettina C, Fries   +2 more
openaire   +2 more sources

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

GENERATION AND CHARACTERIZATION OF POLYCLONAL ANTIBODIES SPECIFIC TO HUMAN ESTROGEN RECEPTOR ERα [PDF]

Biotechnologia Acta
Aim. The purpose of the study was to generate and characterize anti-hERα polyclonal antibodies for elucidation of functional relationships between isoforms of estrogen receptor ERα and isoforms of ribosomal protein S6 kinase — S6K1. Methods.
A.V. Mazov, І. V. Kroupskaya
doaj   +1 more source