Results 121 to 130 of about 19,745 (243)

Using Pharmacokinetic and Pharmacodynamic Analysis to Optimize the Dosing Regimens of Fanastomig (EMB‐02) in Patients With Advanced Solid Tumors

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Fanastomig (also known as EMB‐02) is a bispecific antibody targeting programmed cell death protein‐1(PD‐1) and lymphocyte activation gene‐3 (LAG‐3), developed for the treatment of advanced solid tumors. A first‐in‐human (FIH) Phase I study (NCT04618393) evaluated safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD ...
Chengjun Jiang, Fang Ren, Mingfei Zhang, Qiaoyang Lu, Shuqi Zeng, Guang Yang, Yonghong Zhu   +6 more
wiley   +1 more source

Bayesian Optimization of Antibodies Informed by a Generative Model of Evolving Sequences [PDF]

arXiv
To build effective therapeutics, biologists iteratively mutate antibody sequences to improve binding and stability. Proposed mutations can be informed by previous measurements or by learning from large antibody databases to predict only typical antibodies.
arxiv  

A Model‐Based Approach to Evaluate Anti‐Drug Antibody Impact on Drug Exposure With Biologics: A Case Example With the CD3 T‐Cell Bispecific Cibisatamab

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT The administration of biologics can lead to immunogenic responses that trigger anti‐drug antibody (ADA) formation. ADAs can decrease drug exposure. A population pharmacokinetic (popPK) model was developed to describe clinical PK data with and without ADA‐driven exposure loss with CEA‐directed T‐cell bispecific antibody cibisatamab.
Javier Sanchez, Philippe B. Pierrillas, Nicolas Frey, Gregor P. Lotz, Siv Jönsson, Lena E. Friberg, Nicolas Frances   +6 more
wiley   +1 more source

Bispecific antibodies for the treatment of relapsed/refractory multiple myeloma: updates and future perspectives

Frontiers in Oncology
Patients with relapsed/refractory multiple myeloma (RRMM) that are refractory to the five most active anti-MM drugs, so-called penta-refractory MM, have historically had dismal outcomes with subsequent therapies.
Ricardo D. Parrondo, Sikander Ailawadhi, Claudio Cerchione   +2 more
doaj   +1 more source

Relation-Aware Equivariant Graph Networks for Epitope-Unknown Antibody Design and Specificity Optimization [PDF]

arXiv
Antibodies are Y-shaped proteins that protect the host by binding to specific antigens, and their binding is mainly determined by the Complementary Determining Regions (CDRs) in the antibody. Despite the great progress made in CDR design, existing computational methods still encounter several challenges: 1) poor capability of modeling complex CDRs with
arxiv  

Development of a Heuristic Machine Analogy Method for Model Simplification With an Application to a Large‐Scale Model of Gi/Gs Signaling

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Model simplification is a process to simplify large‐scale mathematical models to enable easy applications such as simulation and parameter estimation. A novel heuristic machine analogy method of model simplification was developed and applied to a motivating example of a model for cAMP signaling switch induced by Gi/Gs pathway competition for ...
Liang Yang, David Finlay, Michelle Glass, Stephen Duffull   +3 more
wiley   +1 more source

Nectin4‐targeted molecular imaging in solid tumors: Current status and future perspectives

VIEW, EarlyView.
In this review, we provide a concise overview of the mechanisms by which Nectin4 contributes to the pathogenesis of various malignancies and detail the classes of Nectin4‐targeted molecular probes. We then delve into the significant advancements in Nectin4‐targeted molecular imaging techniques, encompassing both nuclear medicine and optical imaging ...
Yongshun Liu, Wenpeng Huang, Jingwei Zhou, Rachel J. Saladin, Youlan Lei, Weibo Cai, Lei Kang   +6 more
wiley   +1 more source

Large scale paired antibody language models [PDF]

arXiv
Antibodies are proteins produced by the immune system that can identify and neutralise a wide variety of antigens with high specificity and affinity, and constitute the most successful class of biotherapeutics. With the advent of next-generation sequencing, billions of antibody sequences have been collected in recent years, though their application in ...
arxiv  

Structure of the Fab fragment of a humanized 5E5 antibody to a cancer‐specific Tn‐MUC1 epitope

Acta Crystallographica Section D, EarlyView.
The structure of the humanized Fab from murine monoclonal antibody 5E5 specific for tumor antigen Tn‐MUC1 has been determined to 1.57 Å resolution. The humanization process has imposed changes in the framework regions of the Fv which may have affected the Vh–Vl interface.The structure of the humanized Fab from murine monoclonal antibody 5E5 specific ...
Wei Li, Ulla Mandel, Henk van Faassen, Matthew J. Parker, Max S. G. Legg, Greg Hussack, Henrik Clausen, Stephen V. Evans   +7 more
wiley   +1 more source

Non-affinity platform for processing knob-into-hole bispecific antibody

Bioresources and Bioprocessing
Bispecific antibodies hold significant potential as next-generation biotherapeutics owing to their ability to simultaneously bind to two targets. However, the development of bispecific antibodies as biotherapeutics has been hindered by the high levels of
Xiaoyang Wang, Min Li, Mengting Li, Huoyan Hong, Kai Gao, Puya Zhao   +5 more
doaj   +1 more source