Results 101 to 110 of about 64,981 (166)
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British Medical Bulletin, 1984
The technology for the production of murine monoclonal antibodies has been refined enormously since its introduction in 1975. However, the technology for generating human monoclonal antibodies has only recently come into its own. In this review, three currently available approaches to the production of human monoclonal antibodies are described.
S P, Cole +4 more
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The technology for the production of murine monoclonal antibodies has been refined enormously since its introduction in 1975. However, the technology for generating human monoclonal antibodies has only recently come into its own. In this review, three currently available approaches to the production of human monoclonal antibodies are described.
S P, Cole +4 more
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A human monoclonal antibody to insulin
Diabetes, 1986To elucidate the immune aspects of insulin-dependent diabetes mellitus (IDDM), we attempted to generate human monoclonal anti-insulin antibodies by fusing peripheral blood lymphocytes obtained from 10 insulin-treated IDDM patients with cells from a human lymphoblastoid cell line. Hybridomas that secreted immunoglobulins appeared in 9 of 400 wells.
A, Livneh +5 more
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Monoclonal antibodies to human casein
Molecular Immunology, 1985Two monoclonal antibodies, LICR-LON-32.2 (32.2) and LICR-LON-14.1 (14.1), are described which react with human casein. 32.2 reacts with human beta-casein and 14.1 with human kappa-casein. 32.2 also reacts with rat band 2 casein and bovine beta-casein, but 14.1 appears to be specific for human kappa-casein. These monoclonal antibodies do not cross-react
H M, Earl, R A, McIlhinney
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Monoclonal antibodies to human amnion
Journal of Reproductive Immunology, 1986Mouse hybridoma cell lines secreting monoclonal antibodies to human amnion were established. The reactivities of eight of these monoclonal antibodies (GB1, GB3, GB4, GB5, GB6, GB9, GB10 and GB11) on human skin and term extra-embryonic tissues, which included reflected amniochorions, basal plates, placentae, chorionic plates and umbilical cords, are ...
B L, Hsi, C J, Yeh
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Human and chimpanzee monoclonal antibodies
Journal of Immunological Methods, 1985Monoclonal antibody-secreting cell lines were isolated after transformation of peripheral blood leukocytes with Epstein-Barr virus. Blood samples were obtained from human donors having circulating antibodies against hepatitis viruses (HAB, HBV), rubella, or rabies virus and from a chimpanzee infected with HAV. Dextran-isolated leukocytes were submitted
F C, Van Meel +2 more
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Monoclonal Antibody to Human Cytotrophoblast
American Journal of Reproductive Immunology, 1984ABSTRACT: A monoclonal antibody (18B/A5) has been generated against human first trimester trophoblast membranes which, unlike others so far reported in the literature, reacted only with cytotrophoblast and not with syncytiotrophoblast. Although the identity of the target antigen has not yet been established, the antibody could be a valuable tool for ...
Y W, Loke, S, Day
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Monoclonal Antibodies to Human Choriocarcinoma
American Journal of Reproductive Immunology and Microbiology, 1986ABSTRACT: We have established two monoclonal antibodies (TM7‐3 and TM3‐8) that react to choriocarcinoma cells. Both of these monoclonal antibodies have shown a similar reactive pattern to human cell lines, normal and neoplastic trophoblast tissues, and other fetal and adult tissues.
K, Yamashita +3 more
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Monoclonal antibodies to human erythrocytes
European Journal of Immunology, 1982AbstractEight monoclonal antibodies from mouse hybridomas raised to normal human erythrocytes were tested with a panel of null‐type erythrocytes, enzyme‐treated normal cells, and by inhibition with human erythrocyte sialoglycoproteins. Two antibodies reacted poorly or not at all with RhNULL cells.
D J, Anstee, P A, Edwards
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Monoclonal Antibody to Human Thyrotropin*
The Journal of Clinical Endocrinology & Metabolism, 1982Using the technique of somatic cell fusion, a monoclonal antibody to human TSH (hTSH) has been produced. The monoclonal antibody (anti-hTSH 1/1) has an affinity (Kd = 4.04 x 10(-9) M/liter) for hTSH which is slightly less than that of the polyclonal antisera (Kd = 9.8 x 10(-10) M/liter) derived from the same mouse used for the fusion experiment.
Ridgway, E C +3 more
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