Results 111 to 120 of about 64,981 (166)
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Immunology Today, 1988
Abstract Reproducible and efficient production of human monoclonal antibodies of predefined specificity has proved to be a notoriously difficult task. Many variations on basic production techniques now exist and, as Keith Thompson reviews here, the comparative ease with which they can now be made promises to open up numerous new research avenues.
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Abstract Reproducible and efficient production of human monoclonal antibodies of predefined specificity has proved to be a notoriously difficult task. Many variations on basic production techniques now exist and, as Keith Thompson reviews here, the comparative ease with which they can now be made promises to open up numerous new research avenues.
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Monoclonal Antibodies to Human Nephrin
Hybridoma and Hybridomics, 2004Nephrin is a 180-200-kDa transmembrane protein of the immunoglobulin superfamily. In the kidney, nephrin localizes to the slit diaphragm (SD) between interdigitating podocyte foot processes and mutations in the nephrin gene cause congenital nephrotic syndrome.
Vesa, Ruotsalainen +4 more
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Generating human monoclonal antibodies
Medical Oncology and Tumor Pharmacotherapy, 1984Present methods and systems for the generation of human monoclonal antibodies are briefly reviewed. The specificities of the available reagents are outlined. It would appear that the generation using hybridoma methods of human monoclonal antibodies to human tumor cell surface antigens is a rare event and that methods of in vitro immunostimulation may ...
A M, Neville, P A, Edwards, M J, O'Hare
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Human Monoclonal Antibodies to Human Cytomegalovirus
The Journal of Infectious Diseases, 1989Human monoclonal antibodies (HMAbs) to human cytomegalovirus (HCMV) have been developed by using electric field-induced cell fusion of human B lymphocytes to the human-mouse cell line SBC-H20. By this procedure, multiple hybridomas have been produced that secrete IgG 1 HMAbs with distinct patterns of indirect immunofluorescence on HCMV-infected cells ...
S K, Foung +6 more
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Humanization and Simultaneous Optimization of Monoclonal Antibody
2013Antibody humanization is an essential technology for reducing the potential risk of immunogenicity associated with animal-derived antibodies and has been applied to a majority of the therapeutic antibodies on the market. For developing an antibody molecule as a pharmaceutical at the current biotechnology level, however, other properties also have to be
T, Kuramochi +3 more
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Human Monoclonal Antibodies: The Benefits of Humanization
2018The major reasons for developing human monoclonal antibodies were to be able to efficiently manipulate their effector functions while avoiding immunogenicity seen with rodent antibodies. Those effector functions involve interactions with the complement system and naturally occurring Fc receptors on diverse blood white cells.
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MONOCLONAL ANTIBODIES TO HUMAN TRANSFERRINS
British Journal of Haematology, 1988A B, Mason, S A, Brown, R C, Penhallow
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Humanized Mice as a Tool to Study Sepsis—More Than Meets the Eye
International Journal of Molecular Sciences, 2021, Laudanski Krzysztof
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The development and improvement of immunodeficient mice and humanized immune system mouse models
Frontiers in Immunology, 2022Shuzhen Liao +2 more
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Innovations, challenges, and minimal information for standardization of humanized mice
EMBO Molecular Medicine, 2020Scott Kitchen +2 more
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