Results 231 to 240 of about 245,259 (243)

ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets

The FEBS Journal, EarlyView.
Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna, Alessandro Cherubini, Ersilia Varone, Serena Germani, Alice Marrazza, Ester Zito   +5 more
wiley   +1 more source

Oncolytic Virotherapy in Colorectal Cancer: Mechanistic Insights, Enhancer Strategies, and Translational Combinations. [PDF]

Cells
Salameh H, Naseem N, Chattha MA, Ramesh J, Ramy H, Cizkova D, Kubatka P, Büsselberg D.   +7 more
europepmc   +1 more source

Innate Immune Activation Is a Strong Suppressor of CCL22 and Impedes Regulatory T Cell–Dendritic Cell Interaction

Immunology, EarlyView.
During homeostasis, CCL22 is secreted by dendritic cells (DC), which mediate contacts between regulatory T cells (Treg) and DC to maintain immune balance. Activation of innate immunity via microbes or pattern recognition receptor (PRR) agonists induces the secretion of several soluble factors (e.g., type I and II interferons, IL‐10), which mediate ...
Ignazio Piseddu, Jan Gärtig, Stephan Eiber, Stefan Moder, Raffael Thaler, Matthias Thaler, Juliane Gruen, Marlies Vornhülz, Kevin Bahner, Luana Messa, Benjamin Kühnemuth, Jennifer Müller, Konstantin Schnell, Antonia Beimert, Carolin Perleberg, Natascha Röhrle, Maximilian Martin Ludwig Knott, Linda Hammann, Vanessa Wittmann, Patrick Layritz, Moritz Rapp, Carole Bourquin, Julia Mayerle, Stefan Endres, David Anz   +24 more
wiley   +1 more source

Menin-MLL inhibitors as a new therapeutic target for middle ear cholesteatoma. [PDF]

Sci Rep
Yamamoto-Fukuda T, Akiyama N, Kojima H.
europepmc   +1 more source

Optimizing co-expression strategies for the simultaneous display and secretion of monoclonal antibodies in CHO cells. [PDF]

Sci Rep
Ng JPZ, Mariati M, Ong HK, Bi X, Chang M, Yang Y.   +5 more
europepmc   +1 more source

Editorial: Autoimmune diseases: from molecular mechanisms to therapy development. [PDF]

Front Immunol
Leone P, Susca N, Racanelli V.
europepmc   +1 more source

Optimising Monoclonal Antibody Drug Development for Inflammatory Bowel Disease. [PDF]

Clin Exp Gastroenterol
Colwill M, Honap S, Danese S, Peyrin-Biroulet L.   +3 more
europepmc   +1 more source

Cancer immunotherapy by adenosinergic CD39 and CD73 as emerging immune checkpoints. [PDF]

Discov Oncol
Yin X, Yang Y, Liu S.
europepmc   +1 more source