Results 51 to 60 of about 2,469,529 (358)
Dermatologic Clinics, 2015 Use of monoclonal antibodies (mAbs) has revolutionized cancer therapy. Approaches targeting specific cellular targets on the malignant cells and in tumor microenvironment have been proved to be successful in hematologic malignancies, including cutaneous lymphomas.
openaire +2 more sources
\u3cem\u3eRhizobium leguminosarum\u3c/em\u3e CFN42 Lipopolysaccharide Antigenic Changes Induced by Environmental Conditions [PDF]
, 1992 Four monoclonal antibodies were raised against the lipopolysaccharide of Rhizobium leguminosarum bv. phaseoli CFN42 grown in tryptone and yeast extract.
Brewin, Nicholas J +2 more
core +3 more sources
Scientific Reports, 2021 Protein A affinity chromatography has been widely used for both laboratory scale purification and commercial manufacturing of monoclonal antibodies and Fc-fusion proteins. Protein A purification is specific and efficient.
Yuichi Imura +7 more
doaj +1 more source
Human monoclonal islet specific autoantibodies share features of islet cell and 64 kDa antibodies [PDF]
, 1993 The first human monoclonal islet cell antibodies of the IgG class (MICA 1-6) obtained from an individual with Type 1 (insulin-dependent) diabetes mellitus were cytoplasmic islet cell antibodies selected by the indirect immunofluorescence test on pancreas
DJ Garry +19 more
core +1 more source
The pharmacology and therapeutic applications of monoclonal antibodies
Pharmacology Research & Perspectives, 2019 Monoclonal antibodies (mAbs) have emerged as a major class of therapeutic agents on the market. To date, approximately 80 mAbs have been granted marketing approval.
María Sofía Castelli +2 more
semanticscholar +1 more source
38227 Specific and highly potent human monoclonal antibodies against SARS-CoV-2
Journal of Clinical and Translational Science, 2021 IMPACT: We devised a new method to produce highly potent SARS-CoV2-specific that can be used to treat severely ill patients with Covid-19. OBJECTIVES/GOALS: Neutralizing antibodies against SARS-CoV-2 are thought to offer the most immediate and effective ...
Mayara Garcia de Mattos Barbosa +4 more
doaj +1 more source
Behaviour of the model antibody fluid constrained by rigid spherical obstacles. Effects of the obstacle--antibody attraction [PDF]
arXiv, 2021 This study is concerned with behaviour of fluid of monoclonal antibodies (mAbs) when trapped in a confinement represented by rigid spherical obstacles that attract proteins. The antibody molecule is depicted as an assembly of seven hard spheres, organized to resemble Y shaped molecule.
arxiv
Immunogenicity of Innovative and Biosimilar Monoclonal Antibodies
Antibodies, 2019 The development of hybridoma technology for producing monoclonal antibodies (mAbs) by Kohler and Milstein (1975) counts as one of the major medical breakthroughs, opening up endless possibilities for research, diagnosis and for treatment of a whole ...
Erik Doevendans, H. Schellekens
semanticscholar +1 more source
Monoclonal Antibodies as Immune Modulators for Cancer Therapy
Canadian Journal of Infectious Diseases, 1992 Monoclonal antibodies may modulate immune and/or biological responses alone, or as carriers of specific agents. Monoclonal antibodies directed against tumours may be indirectly cytotoxic by modulation of antibody-dependent, cell-mediated cytotoxicity or ...
Robert O Dillman
doaj +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source