Results 61 to 70 of about 1,274,843 (306)

A dual-action humanized DKK-1 antibody that activates the Wnt/β-catenin signaling pathway and inhibits the RANKL signaling pathway for osteoporosis therapy

Frontiers in Immunology
IntroductionOsteoporosis remains a major global health challenge, and current single-pathway therapies often fail to achieve coordinated bone remodeling. Dickkopf-1 (DKK-1) is a potent inhibitor of the Wnt/β-catenin signaling pathway and plays a critical
Sheng Hou, Sheng Hou, Sheng Hou, Sheng Hou, Tianyu Gao, Tianyu Gao, Tianyu Gao, Yimei Wu, Yimei Wu, Hao Wang, Hao Wang, Hao Wang, Hao Wang, Dapeng Zhang, Dapeng Zhang, Dapeng Zhang, Dapeng Zhang, Qingcheng Guo, Qingcheng Guo, Qingcheng Guo, Qingcheng Guo, Jin Xu, Jin Xu, Jin Xu, Huaizu Guo, Huaizu Guo, Huaizu Guo, Weizhu Qian, Weizhu Qian, Weizhu Qian, Weizhu Qian   +30 more
doaj   +1 more source

Immunotoxicity of monoclonal antibodies [PDF]

mAbs, 2009
Monoclonal antibodies (mAbs) are large molecules intended to bind to specific targets often expressed on the immune system, and to treat various immunopathological conditions. Therefore, mAbs can be considered to have a high potential for immunotoxicity, which is reflected in the clinical experience accumulated on mAbs-induced adverse effects related ...
openaire   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The production of polyclonal, monoclonal and genetically-derived scFv antibody fragments for the detection of the ß-lactam antibiotic, cephalexin, in milk [PDF]

, 2006
This thesis describes the production of antibodies for the detection of cephalexin and their application in ELISA and Biacore ‘real-time’ surface plasmon resonance (SPR)-based biosensor assays.
Darmanin Sheehan, Alfredo
core   +2 more sources

Production, characterization, and antigen specificity of recombinant 62-71-3, a candidate monoclonal antibody for rabies prophylaxis in humans [PDF]

, 2013
Rabies kills many people throughout the developing world every year. The murine monoclonal antibody (mAb) 62-71-3 was recently identified for its potential application in rabies postexposure prophylaxis (PEP).
Both, L, Bulmer-Thomas, B., Banyard, AC, Selden, D., Altmann, F, Craig van Dolleweerd (406086), David Selden (4911475), Selden, D, Ashley C Banyard (16267520), Both, L., Banyard, A.C., Edward Wright (4468198), Bulmer-Thomas, B, Fooks, AR, Friedrich Altmann (33138), Wright, E, van Dolleweerd, C., Fooks, A.R., Ma, J.K.C., Julian K C Ma (16267529), Leonard Both (16267517), van Dolleweerd, C, Ma, JK, Wright, E., Altmann, F., Anthony R Fooks (16267526), Bianca Bulmer-Thomas (16267523)   +26 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Monoclonal antibodies in treatment of non-small cell lung cancer

, 2022
Battling with various types of cancerous diseases has been one of the greatest areas of national and global medical endeavors in the late 20th and during the 21st centuries.
Shahni Danesh, Sina
core  

In Vivo Emergence of HIV-1 Highly Sensitive to Neutralizing Antibodies [PDF]

, 2011
Background: The rapid and continual viral escape from neutralizing antibodies is well documented in HIV-1 infection. Here we report in vivo emergence of viruses with heightened sensitivity to neutralizing antibodies, sometimes paralleling the development
O'Farrell Stephen, Pellegrino, P, Williams Ian, Williams, IG, Kelly M Cheney, Áine McKnight, Anna Forsman, Cheney, Kelly M, McKnight, Áine, Cheney Kelly M., Hué, Stéphane, Forsman Anna, Marlén M I Aasa-Chapman, McKnight, A, Marlén M. I. Aasa-Chapman, Ian Williams, Aasa-Chapman, Marlén MI, Cheney, KM, O'Farrell, S, Stéphane Hué, Kelly M. Cheney, Pellegrino, Pierre, Stephen O'Farrell, Forsman, A, O'Farrell, Stephen, Pierre Pellegrino, Williams, Ian, Forsman, Anna, Aasa-Chapman Marlén M. I., Aasa-Chapman, MMI, Hué Stéphane, McKnight Áine, Pellegrino Pierre, Williams, I, Hue, S, Aasa-Chapman, MM   +35 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source