Hepatitis C virus (HCV) infection may elicit neutralizing antibodies targeting epitopes conserved in all viral genotypes [PDF]
PLoS ONE, 2009 Anti-hepatitis C virus (HCV) cross-neutralizing human monoclonal antibodies, directed against conserved epitopes on surface E2 glycoprotein, are central tools for understanding virus-host interplay, and for planning strategies for prevention and ...
Arvind H. Patel +10 more
core +21 more sources
COVID-19: are neutralizing antibodies neutralizing enough? [PDF]
Transfusion, 2020 Kadkhoda K.
europepmc +5 more sources
Phage display selection of HIV specific conserved mimotopes with IgG from long-term non-progressors [PDF]
, 2005 Poster presentation Background The aim of this study is to identify conserved epitopes of HIV-1 neutralizing antibodies in polyclonal plasma from LTNP to finally derive vaccine candidates.
Antoni, Sascha +6 more
core +1 more source
Neutralization of Diverse Human Cytomegalovirus Strains Conferred by Antibodies Targeting Viral gH/gL/pUL128-131 Pentameric Complex [PDF]
, 2017 Human cytomegalovirus (HCMV) is the leading cause of congenital viral infection, and developing a prophylactic vaccine is of high priority to public health.
Adler, Stuart P. +19 more
core +3 more sources
Neutralizing Antibody Therapeutics for COVID-19 [PDF]
Viruses, 2021 The emergence of SARS-CoV-2 and subsequent COVID-19 pandemic has resulted in a significant global public health burden, leading to an urgent need for effective therapeutic strategies. In this article, we review the role of SARS-CoV-2 neutralizing antibodies (nAbs) in the clinical management of COVID-19 and provide an overview of recent randomized ...
Hurt, AC, Wheatley, AK
openaire +5 more sources
Functional stability of HIV-1 envelope trimer affects accessibility to broadly neutralizing antibodies at its apex [PDF]
, 2017 The trimeric envelope glycoprotein spike (Env) of HIV-1 is the target of vaccine development to elicit broadly neutralizing antibodies (bnAbs). Env trimer instability and heterogeneity in principle make subunit interfaces inconsistent targets for the ...
Gift, Syna Kuriakose +4 more
core +2 more sources
Characterization of monoclonal and polyclonal antibodies to bovine enteric coronavirus: Establishment of an efficient ELISA for antigen detection in feces [PDF]
, 1989 Monoclonal antibodies to bovine enteric coronavirus (BEC) were produced. Additionally, polyclonal antibodies were made in rabbits and guinea pigs and extracted from the yolk of immunized hens.
Czerny, C. P., Eichhorn, Werner
core +1 more source
Development of an experimental inactivated PRRSV vaccine that induces virus-neutralizing antibodies [PDF]
, 2009 Porcine reproductive and respiratory syndrome virus (PRRSV) can induce reproductive disorders and is involved in the porcine respiratory disease complex, causing tremendous economic losses to the swine industry.
Delputte, Peter +4 more
core +3 more sources
Isolation of Neutralizing Antibody
BIO-PROTOCOL, 2013 Use of monoclonal antibodies (MAbs) is an established laboratory strategy for characterization of specific pathogens and their antigenicity. Especially, Human MAbs (HuMAbs) with neutralizing activity against specific virus could have potential therapeutic application, and provide significant information on human epitopes that could be important for ...
Mayo Yasugi, Kazuyoshi Ikuta
openaire +3 more sources
Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding [PDF]
, 2011 Passive transfer of broadly neutralizing HIV antibodies can prevent infection, which suggests that vaccines that elicit such antibodies would be protective.
Abadir, Alexander +21 more
core +2 more sources