Potent human neutralizing antibodies elicited by SARS-CoV-2 infection
bioRxiv, 2020 The pandemic caused by emerging coronavirus SARS-CoV-2 presents a serious global public health emergency in urgent need of prophylactic and therapeutic interventions.
B. Ju +21 more
semanticscholar +1 more source
Antigenic variation among murine coronaviruses: evidence for polymorphism on the peplomer glycoprotein, E2. [PDF]
, 1985 A panel of 28 monoclonal antibodies (MAb) against the structural proteins of murine hepatitis virus-4, strain JHM (MHV-4) was used in three antigen binding assays to determine the extent of antigenic homology among six strains of murine coronaviruses ...
Buchmeier, MJ, Talbot, PJ
core
An investigation of the breadth of neutralising antibody response in cats naturally infected with feline immunodeficiency virus [PDF]
, 2015 Neutralising antibodies (NAbs) are believed to comprise an essential component of the protective immune response induced by vaccines against FIV and HIV infections.
Beczkowski, Pawel +5 more
core +2 more sources
Neutralization of HIV-1 by antibody
Current Opinion in Immunology, 1996 The humoral immune response to HIV-1 has been extensively studied over the past few years and considerable advances have been made in understanding the dynamics and specificity of the neutralizing antibody component during and after seroconversion. Despite this, there is still no clear understanding of the role of neutralizing antibodies in controlling
openaire +3 more sources
Pharmacokinetics and pharmacodynamics of VEGF-neutralizing antibodies [PDF]
BMC Systems Biology, 2011 Vascular endothelial growth factor (VEGF) is a potent regulator of angiogenesis, and its role in cancer biology has been widely studied. Many cancer therapies target angiogenesis, with a focus being on VEGF-mediated signaling such as antibodies to VEGF. However, it is difficult to predict the effects of VEGF-neutralizing agents.
P. I. Imoukhuede +3 more
openaire +3 more sources
Comparative study of adenosine 3′‐pyrophosphokinase domains of MuF polymorphic toxins
FEBS Open Bio, EarlyView.With the ultimate goal of understanding the association of toxin‐immunity modules to temperate phages, we characterized toxins from three prophages and examined cross‐protection from immunity proteins. The toxins exhibit adenosine 3′‐pyrophosphokinase activity and are toxic in Escherichia coli.
Eloïse M. Paulet +6 more
wiley +1 more source
AbODE: Ab Initio Antibody Design using Conjoined ODEs [PDF]
arXiv, 2023 Antibodies are Y-shaped proteins that neutralize pathogens and constitute the core of our adaptive immune system. De novo generation of new antibodies that target specific antigens holds the key to accelerating vaccine discovery. However, this co-design of the amino acid sequence and the 3D structure subsumes and accentuates some central challenges ...
arxiv
Potent Neutralizing Antibodies Directed to Multiple Epitopes on SARS-CoV-2 Spike
bioRxiv, 2020 The SARS-CoV-2 pandemic rages on with devasting consequences on human lives and the global economy1,2. The discovery and development of virus-neutralizing monoclonal antibodies could be one approach to treat or prevent infection by this novel coronavirus.
Lihong Liu +23 more
semanticscholar +1 more source
Possible immunoenhancement of persistent viremia by feline leukemia virus envelope glycoprotein vaccines in challenge-exposure situations where whole inactivated virus vaccines were protective. [PDF]
, 1986 Kittens immunized with purified native FeLV-gp70 or -gp85 envelope proteins developed ELISA, but not virus neutralizing, antibodies in their serum to both whole FeLV and FeLV-gp70.
Birch, D +3 more
core
Broadly Neutralizing Antibodies for HIV Eradication [PDF]
Current HIV/AIDS Reports, 2016 Passive transfer of antibodies has long been considered a potential treatment modality for infectious diseases, including HIV. Early efforts to use antibodies to suppress HIV replication, however, were largely unsuccessful, as the antibodies that were studied neutralized only a relatively narrow spectrum of viral strains and were not very potent ...
Kathryn E. Stephenson +3 more
openaire +4 more sources