Results 241 to 250 of about 294,536 (285)

A Quantum Framework for Protein Binding‐Site Structure Prediction on Utility‐Level Quantum Processors

Advanced Science, EarlyView.
This study presents a hybrid quantum‐classical framework for accurate prediction of protein structures on utility‐level quantum processors. We evaluate the practical application of the Variational Quantum Eigen‐solver (VQE) in protein structure prediction and demonstrate its superiority over state‐of‐the‐art deep learning methods in molecular docking ...
Yuqi Zhang, Yuxin Yang, William Martin, Kingsten Lin, Zixu Wang, Cheng‐Chang Lu, Weiwen Jiang, Ruth Nussinov, Joseph Loscalzo, Qiang Guan, Feixiong Cheng   +10 more
wiley   +1 more source

Venezuelan Equine Encephalitis Virus: Structural Biology, Vaccines, and Advances in Functional Antibodies. [PDF]

Vaccines (Basel)
Tang R, Wang D, Chen G, Liu C, Zhang L, Peng F, Yu J, Li X, Luo H, Wen Y, Qiao C.   +10 more
europepmc   +1 more source

HSP70 Interactome‐Mediated Proteolysis Targeting Chimera (HSP70‐PROTAC) for Ferroptosis‐Driven Cancer Treatment

Advanced Science, EarlyView.
This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong, Yulong Li, Hui Liang, Zumei Wu, Shiqun Wang, Yichao Wang, Jieyu Xu, Yanning Lan, Maohua Cai, Guangzhao Pan, Haiyan Yang, Kai Miao, Zhe‐Sheng Chen, Fangfang Tao, Xuelei Ma, Jiang‐Jiang Qin   +15 more
wiley   +1 more source

In Silico Ligand-Based Screening of PDB Database for Searching Unique Motifs Against SARS-CoV-2. [PDF]

Biomolecules
Machulin AV, Badaeva JV, Grishin SY, Deryusheva EI, Galzitskaya OV.   +4 more
europepmc   +1 more source

ITGB1 Regulates Triple‐Negative Breast Cancer Development by Modulating the Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumorigenesis and metastasis are frequently attributed to the intricate interplay between cancer cells and the tumor microenvironment (TME). Comprehending the mechanisms and key regulators of cancer‐immune crosstalk in the TME is imperative for developing efficacious immunotherapy.
Nuozi Song, Siqi Chen, Lei Wang, Jessica Dang, Xu Cao, Stephanie Singh, Lu Yang, Jinhui Wang, Steven T. Rosen, Yingyu Wang, Chun‐Wei D. Chen, Cheng Zhang, Mingye Feng   +12 more
wiley   +1 more source

Dissecting antibody-dependent enhancement modulation by Fc-modified cross-neutralizing human monoclonal antibody. [PDF]

PeerJ
Injampa S, Benjathummarak S, Keadsanti S, Sootichote R, Puangmanee W, Yamanaka A, Sasaki T, Ramasoota P, Pitaksajjakul P.   +8 more
europepmc   +1 more source

DNA Nanostructure‐Templated Multivalency Enables Broad‐Spectrum Virus Inhibition

Advanced Science, EarlyView.
A honeycomb‐shaped DNA nanostructure is introduced that organizes nanobodies or aptamers into trimeric clusters mirroring the native hemagglutinin arrangement on influenza viruses. This geometry‐matched multivalency enhances binding avidity by up to 1000‐fold, resulting in robust, broad‐spectrum viral neutralization and a 30–55% improvement in host ...
Saurabh Umrao, Abhisek Dwivedy, Dhanush Gandavadi, Chi Chen, Lifeng Zhou, Jinwei Duan, Vineetha Mareddy, Ying Fang, Xing Wang   +8 more
wiley   +1 more source

Antigenicity of key hepatitis C virus E1E2 glycoprotein neutralizing sites is genotype independent. [PDF]

J Gen Virol
Mimms JL, Sinnis-Bourozikas A, Felbinger NR, Frumento N, Paul HT, Patel AH, Keck Z, Foung SKH, Law M, Urbanowicz RA, Tarr AW, Ball JK, Pierce BG, Bailey JR.   +13 more
europepmc   +1 more source

Profiling Human Papillomavirus Lineage-Specific Capsid Antigenicity With Geographically Diverse Natural Infection Antibodies. [PDF]

J Infect Dis
Panwar K, Yokoya K, Gomes S, Tenet V, Schussler J, Herrero R, Mirabello L, Schiller JT, Sierra MS, Clifford GM, Beddows S.   +10 more
europepmc   +1 more source