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Antibody Neutralization in Hypoprothrombinaemic Plasma
Pathophysiology of Haemostasis and Thrombosis, 1972The technique of antibody neutralization has been used to study the plasma of a large group of patients with hypoprothrombinaemia of diverse causes. The associated disorders included obstructive jaundice, acute infective hepatitis and chronic parenchymal liver disease. A number of patients were receiving warfarin and salicylate therapy. Irrespective of
J D, Parkin, F, Madaras, P A, Castaldi
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Neutralizing antibody in rodent malaria
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1975Small numbers of rat erythrocytes infected with viable P. berghei, when inoculated into susceptible rats together with hyperimmune rat serum (HIS), are fully neutralized. Serum from convalescent rats delays the onset of patency but does not neutralize. The neutralizing efficiency of HIS rises in proportion to the number of successive reinoculations of ...
J, Golenser, D T, Spira, A, Zuckerman
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Protective neutralizing antibodies
Science, 2020Coronavirus Antibodies produced by survivors of coronavirus disease 2019 (COVID-19) may be leveraged to develop therapies. A first step is identifying neutralizing antibodies, which confer strong protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Rogers et al.
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Neutralizing antibodies to interferon
Neurology, 2007The impact of neutralizing antibodies (NAbs) to interferon-beta (IFN-beta) on clinical and imaging parameters in multiple sclerosis (MS) is reviewed. An effect on relapse rates and imaging parameters was noted in patients who tested positive for NAbs, but disability measures were unaffected or showed a trend toward improvement.
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Neutralizing antibody in nonallergic individuals
Journal of Allergy, 1952Abstract Neutralizing antibody titrations were carried out in series of nonatopic human volunteers receiving one of the following ragweed preparations: (1) aqueous, (2) dialyzed aqueous, (3) alum precipitated, and (4) tannic acid precipitated extract. Also, extracts were made up to contain one of the following: (5) 10 per cent polyvinylpyrrolidone, (6)
S, MALKIEL, S M, FEINBERG
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Production of Neutralizing Antibody
Techniques employing monoclonal antibodies (mAbs) are widely used in the initial development phase of biologics. The usefulness of mAbs in basic RA research has been established based on their characteristics, including specificity of binding, homogeneity, and ability to be produced on a large scale.Erika, Takemasa, Shuang, Liu
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Testing for neutralizing antibodies
British Journal of Neuroscience Nursing, 2007Interferon-beta drugs for multiple sclerosis sometimes give rise to immune proteins that neutralize their effects. Nicola O'Connell and Bronwen Roper look at testing for these neutralizing antibodies
Nicola O'Connell, Bronwen Roper
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Statistical issues in neutralizing antibodies
Neurology, 2003Frequently the question of the effects of neutralizing antibodies (NAbs) is stated, but not clearly. Some ask: “Are we sure NAbs are important?” And others ask: “Are we sure NAbs are NOT important?” These two questions can lead to different statistical designs and different approaches to the investigation of the impact of NAbs.
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Neutralization of HIV by Antibodies
2008Antibodies can neutralize HIV-1 with potency and cross-reactivity that varies widely and is related but not correlated to their antigen-binding affinity. Therefore, in addition to measuring binding affinity, an evaluation of the antibody neutralizing activity in tissue cultures is important for development of antibody-based therapeutics, design of ...
Ilia, Prado +2 more
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Sensitive neutralization test for virus antibody
Archives of Virology, 1978A sensitive mumps virus plaque neutralization test has been developed based on the potentiation of virus-antibody complexes by heterologous anti-immunoglobulins (AIG). The enhanced neutralization test was approximately 100 times more sensitive than the conventional neutralization test or the hemagglutination-inhibition test.
H, Sato +4 more
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