Results 281 to 290 of about 1,849,608 (371)

Screening of Neutralizing Antibodies Targeting Gc Protein of RVFV. [PDF]

Viruses
Zhao C, Hao M, Bian T, Zhao X, Chi X, Chen Z, Fu G, Zhu Z, Fang T, Yu C, Li J, Chen W.   +11 more
europepmc   +1 more source

C1q+ Macrophage–Tumor Cell Interaction Promoted Tumorigenesis via GPR17/PI3K/AKT Pathway Induced DNA Hypermethylation in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
In the TME of NPC, C1q secreted by C1q+ TAMs interacted with GPR17 to activate PI3K/AKT signaling through strengthening GPR17 coupling PI3K and increasing calcium levels in tumor cells. The activated PI3K/AKT signaling further induces DNA hypermethylation to promote the malignancy and stemness of tumor cells.
Yunzhi Liu, Cuicui Huang, Min Luo, Wenfu Lu, Baifeng Zhang, Lu Bai, Shuyue Zheng, Yanan Tan, Shanshan Li, Huali Wang, Lanqi Gong, Xinyuan Guan   +11 more
wiley   +1 more source

Passive Immunization in the Prevention and Treatment of Viral Infections. [PDF]

Eur J Immunol
Moirangthem R, Bar-On Y.
europepmc   +1 more source

CD103+ T Cells Eliminate Damaged Alveolar Epithelial Type II Cells Under Oxidative Stress to Prevent Lung Tumorigenesis

Advanced Science, EarlyView.
This work unravels a novel function of CD103+ T cells in eradicating oxidative‐stressed somatic cells to prevent lung tumorigenesis and identifies specific CD103+ T cell‐decline as a key feature in the aged lung. This comprehensive study highlights the contribution of immuno‐dysregulation to the high incidence of aging‐associated lung cancers ...
Yu Xu, Haorui Luo, Jiahao Wang, Haifeng Liu, Luonan Chen, Hongbin Ji, Zimu Deng, Xiaolong Liu   +7 more
wiley   +1 more source

Comparison of the induction of neutralizing antibodies against Bas congo virus using several vaccine modalities. [PDF]

Sci Rep
Park ES, Yoshikawa T, Tani H, Kimura M, Kaku Y, Imaoka K, Maeda K, Saijo M, Morikawa S.   +8 more
europepmc   +1 more source

Targeted Penetrating Motif Engineering of BH3 Mimetic: Harnessing Non‐Canonical Amino Acids for Coinhibition of MCL‐1 and BCL‐xL in Acute Myeloid Leukemia

Advanced Science, EarlyView.
A structure‐guided peptide derived from a non‐canonical amino acid library simultaneously targets MCL‐1 and BCL‐xL to overcome apoptotic resistance in acute myeloid leukemia. Fused with a CXCR4‐binding motif, the engineered peptide exhibits selective intracellular delivery and potent in vivo efficacy, offering a promising therapeutic strategy against ...
Zhe Wang, Ruizhi Lai, Xinpei Wang, Xu Chen, Youjian Zhou, Shengbin Li, Xiaohui Qiu, Zekai Zeng, Jianye Yuan, Jinghuan Mao, Zhidong Chen, Junqing Wang   +11 more
wiley   +1 more source

Mpox multiprotein virus-like nanoparticle vaccine induces neutralizing and protective antibodies in mice and non-human primates. [PDF]

Nat Commun
Belghith AA, Cotter CA, Ignacio MA, Earl PL, Hills RA, Howarth MR, Yee DS, Brenchley JM, Moss B.   +8 more
europepmc   +1 more source

Inhibition of Heat Shock Protein 90β by Catalpol: A Potential Therapeutic Approach for Alleviating Inflammation‐Induced Cartilage Injuries in Osteoarthritis

Advanced Science, EarlyView.
The schematic diagram delineates the chondroprotective effects of Ca‐bMSN in OA models. The upper portion of the diagram depicts the synthesis process of Ca‐bMSN. The lower section illustrates the post‐injection of Ca‐bMSN in joint cavity, catalpol released and subsequently mediates the reduction of oxidative stress, ECM catabolism, apoptosis, and ...
Zhenwei Zhou, Binghua Zhang, Lang Liu, Jie Yang, Yuting Wang, Cheng Lv, He Zhang, Yuchi Wei, Zhanliang Jiang, Zeyu Peng, Daqing Zhao, Xiangyang Leng, Xiangyan Li, Hang Su, Haisi Dong   +14 more
wiley   +1 more source

Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques

Science, 2017
Ling Xu, A. Pegu, Ercole Rao, N. Doria-Rose, J. Beninga, K. Mckee, D. Lord, R. Wei, G. Deng, M. Louder, S. Schmidt, Z. Mankoff, Lan Wu, M. Asokan, Christian Beil, Christian Lange, W. D. Leuschner, J. Kruip, R. Sendak, Young Do Kwon, T. Zhou, Xuejun Chen, R. Bailer, Keyun Wang, M. Choe, Lawrence J. Tartaglia, D. Barouch, S. O'dell, J. Todd, D. Burton, M. Roederer, M. Connors, R. Koup, P. Kwong, Zhi-yong Yang, J. Mascola, G. Nabel   +36 more
semanticscholar   +1 more source

Novel Trispecific Neutralizing Antibodies With Enhanced Potency and Breadth Against Pan-Sarbecoviruses. [PDF]

MedComm (2020)
Qiao R, Liu Y, Mao Q, Li J, Lu Y, Shi J, Li C, Yu J, Gong J, Wang X, Shao Y, Sun L, Zhang W, Yu H, Chu H, Wang P, Zhao X.   +16 more
europepmc   +1 more source