Results 291 to 300 of about 1,849,608 (371)

An Off‐the‐Shelf Artificial Blood Clot Hydrogel Neutralizing Multiple Proinflammatory Mediators for Pro‐Regenerative Periodontitis Treatment

Advanced Science, EarlyView.
CCS‐RSF@PRP hydrogel is engineered to structurally and functionally mimic the blood clot by integrating PPR, CCS, and RSF nanofibers through in situ activation of PRP. In a rat periodontitis model, CCS‐RSF@PRP hydrogel effectively promotes periodontal tissue repair, attributing to neutralizing the multiple proinflammatory mediators, thus rebuilding a ...
Yini Huangfu, Zhezhe Zhao, Xiang Liu, Jingrong Wang, Yufeng Zhang, Tingting Lan, Yonglan Wang, Chenxuan Wu, Ju Zhang, Pingsheng Huang, Chuangnian Zhang, Anjie Dong, Zujian Feng, Deling Kong, Weiwei Wang   +14 more
wiley   +1 more source

Staged induction of HIV-1 glycan–dependent broadly neutralizing antibodies

Science Translational Medicine, 2017
M. Bonsignori, Edward F. Kreider, D. Fera, R. Meyerhoff, T. Bradley, K. Wiehe, S. Alam, Baptiste Aussedat, William E. Walkowicz, K. Hwang, K. Saunders, Ruijun Zhang, Morgan A. Gladden, Anthony Monroe, Amit Kumar, S. Xia, M. Cooper, M. Louder, K. Mckee, R. Bailer, Brendan W. Pier, C. A. Jette, G. Kelsoe, W. Williams, L. Morris, J. Kappes, K. Wagh, G. Kamanga, M. Cohen, P. Hraber, D. Montefiori, Ashley Trama, H. Liao, T. Kepler, M. Moody, F. Gao, S. Danishefsky, J. Mascola, G. Shaw, B. Hahn, S. Harrison, Bette T. Korber, B. Haynes   +42 more
semanticscholar   +1 more source

A high-throughput, fully automated competition assay to evaluate SARS-CoV-2 neutralizing responses and epitope specificity in clinical samples. [PDF]

Sci Rep
Atarashi Y, Kim J, Irino Y, Amano M, Tsuchiya K, Maeda K, Terada M, Iwamoto N, Shimada S, Mitsuya H, Yanagida M, Takamatsu Y.   +11 more
europepmc   +1 more source

Visualization of the Spiral Ganglion Neuron in Vivo Using a Novel 177Lu Nuclear Molecule Label

Advanced Science, EarlyView.
The study developed and validated a radionuclide‐labeled anti‐VGLUT1 antibody probe for the first nuclear imaging of cochlear spiral ganglion neurons (SGNs) in vivo. This approach may provide aid in screening candidates suitable for CI surgery by quantifying the number of surviving SGNs, and predicting the potential for postoperative hearing ...
Chenyang Kong, Xiaohui Wang, Jintao Yu, Li Wen, Chengwen Zheng, Ge Yin, Kai Xu, Weiwei He, Hao Wang, Xiaoli Lan, Dawei Jiang, Yu Sun   +11 more
wiley   +1 more source

Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice

Nature, 2016
G. Sapparapu, Estefania Fernandez, Nurgun Kose, B. Cao, J. Fox, Robin Bombardi, Haiyan Zhao, C. Nelson, A. Bryan, Trevor Barnes, E. Davidson, I. Mysorekar, D. Fremont, B. Doranz, M. Diamond, J. Crowe   +15 more
semanticscholar   +1 more source

Current status of the immunogenicity of enzyme replacement therapy in fabry disease. [PDF]

Orphanet J Rare Dis
Gómez-Cerezo JF, Fernández-Martín J, Barba-Romero MÁ, Sánchez-Martínez R, Hermida-Ameijeiras A, Camprodon-Gómez M, Ortolano S, Lopez-Rodriguez MA.   +7 more
europepmc   +1 more source

Precision‐Guided Stealth Missiles in Biomedicine: Biological Carrier‐Mediated Nanomedicine Hitchhiking Strategy

Advanced Science, EarlyView.
Diagram illustrating the binding methods of NPs and biological barriers. The biological carrier‐mediated nanomedicine hitchhiking strategy (BCM‐NHS) utilizes two distinct techniques: the surface‐based “Backpack” method, which relies on ligand‐receptor binding, covalent conjugation, and non‐covalent binding, and the encapsulated “Trojan horse” approach,
Yuyan Zhou, Xinyue Wang, Deyu Zhang, Hanxiao Cui, Xiaorong Tian, Wei Du, Zhenghui Yang, Dongling Wan, Zhiwei Qiu, Chao Liu, Zhicheng Yang, Lizhihong Zhang, Qiusheng Yang, Xuefeng Xu, Wenhao Li, Dong Wang, Haojie Huang, Wencheng Wu   +17 more
wiley   +1 more source

Development of a potent neutralizing nanobody against canine distemper virus hemagglutinin protein. [PDF]

Front Immunol
Xiao L, Wu Z, Su J, Wu Q.
europepmc   +1 more source

Tβ4‐Engineered ADSC Extracellular Vesicles Rescue Cell Senescence Through Separable Microneedle Patches for Diabetic Wound Healing

Advanced Science, EarlyView.
A separable microneedle patch is designed for Tβ4–modified ADSC‐derived extracellular vesicles delivery. The overexpressed Tβ4 released from the microneedles can mitigate cellular senescence and promote wound healing via the PTEN/PI3K/AKT pathway, offering a promising approach for diabetic wound treatment. This bioengineered therapeutic system serve as
Youjun Ding, Jinglin Wang, Jiaye Li, Yi Cheng, Shuyin Zhou, Yepeng Zhang, Yuanjin Zhao, Min Zhou   +7 more
wiley   +1 more source

Powassan and Eastern Equine Encephalitis Virus Seroprevalence in Endemic Areas, United States, 2019-2020. [PDF]

Emerg Infect Dis
Padda H, Huang CY, Grimm K, Biggerstaff BJ, Ledermann JP, Raetz J, Boroughs K, Mossel EC, Martin SW, Lehman JA, Townsend RL, Krysztof D, Saá P, Dinh ETN, Stobierski MG, Esponda-Morrison B, Wolujewicz KAA, Osborne M, Brown CM, Hopkins B, Schiffman EK, Garvin A, Lee X, Osborn RA, Wozniak RJ, Brault AC, Basavaraju SV, Stramer SL, Staples JE, Gould CV.   +29 more
europepmc   +1 more source