Results 31 to 40 of about 1,727,618 (310)

Isolation of Neutralizing Antibody

BIO-PROTOCOL, 2013
Use of monoclonal antibodies (MAbs) is an established laboratory strategy for characterization of specific pathogens and their antigenicity. Especially, Human MAbs (HuMAbs) with neutralizing activity against specific virus could have potential therapeutic application, and provide significant information on human epitopes that could be important for ...
Mayo Yasugi, Kazuyoshi Ikuta
openaire   +3 more sources

A sensitive and reproducible cell-based assay via secNanoLuc to detect neutralizing antibody against adeno-associated virus vector capsid

Molecular Therapy: Methods & Clinical Development, 2021
Most gene therapy clinical trials that systemically administered adeno-associated virus (AAV) vector enrolled only patients without anti-AAV-neutralizing antibodies.
Nemekhbayar Baatartsogt, Yuji Kashiwakura, Morisada Hayakawa, Nobuhiko Kamoshita, Takafumi Hiramoto, Hiroaki Mizukami, Tsukasa Ohmori   +6 more
doaj  

Neutralizing Antibodies against SARS-CoV2

Medical Journal of Dr. D.Y. Patil Vidyapeeth, 2023
Coronavirus disease 2019 (COVID-19) is an illness due to a novel coronavirus which is Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Though this virus is recently identified in 2019, it is closely related to other coronaviruses namely SARS-
Prachi Athavale, Virendra Athavale, Poonam Suryawanshi, Kishor Khillare, Srikanth Tripathy   +4 more
doaj   +1 more source

Cross-reactive broadly neutralizing antibodies: timing is everything

Frontiers in Immunology, 2012
The recent surge of research into new broadly neutralizing antibodies in HIV-1 infection has recharged the field of HIV-1 vaccinology. In this review we discuss the currently known broadly neutralizing antibodies and focus on factors that may shape these
Zelda eEuler, Hanneke eSchuitemaker, Hanneke eSchuitemaker   +2 more
doaj   +1 more source

SARS-CoV-2 variant B.1.1.7 is susceptible to neutralizing antibodies elicited by ancestral Spike vaccines

bioRxiv, 2021
The SARS-CoV-2 Spike glycoprotein mediates virus entry and is a major target for neutralizing antibodies. All current vaccines are based on the ancestral Spike with the goal of generating a protective neutralizing antibody response.
Xiaoying Shen, Haili Tang, C. McDanal, K. Wagh, W. Fischer, J. Theiler, Hyejin Yoon, Dapeng Li, B. Haynes, Kevin O. Sanders, S. Gnanakaran, N. Hengartner, R. Pajon, Gale Smith, F. Dubovsky, G. Glenn, Bette Korber, D. Montefiori   +17 more
semanticscholar   +1 more source

Antibody and Virus: Binding and Neutralization

Virology, 2000
During infection with an enveloped virus, antibodiesare elicited to envelope proteins. Some of these antibod-ies bind to envelope spikes on the virion, some bind tononvirion forms of the envelope (“viral debris”), and somebind to both. The relative amounts of different antibodytypes elicited varies from virus to virus.
Paul W. H. I. Parren, R. Anthony Williamson, Dennis R. Burton   +2 more
openaire   +2 more sources

COVID-19 neutralizing antibodies predict disease severity and survival

medRxiv, 2020
COVID-19 exhibits variable symptom severity ranging from asymptomatic to life-threatening, yet the relationship between severity and the humoral immune response is poorly understood.
W. García-Beltrán, E. Lam, M. Astudillo, Diane Yang, T. Miller, J. Feldman, B. Hauser, T. Caradonna, K. Clayton, Adam D Nitido, M. Murali, G. Alter, R. Charles, A. Dighe, J. Branda, J. Lennerz, D. Lingwood, A. Schmidt, A. Iafrate, A. Balazs   +19 more
semanticscholar   +2 more sources

ZIKV Envelope Domain-Specific Antibodies: Production, Purification and Characterization

Viruses, 2019
Infection with Zika virus (ZIKV) came first to public attention after it was found to be associated with congenital microcephaly during the outbreak in Brazil (2015–2016). Diagnosis of ZIKV suffers from extensive cross-reactivity with other Flaviviruses,
Sami Akhras, Marie-Luise Herrlein, Fabian Elgner, Thomas Holzhauser, Eberhard Hildt   +4 more
doaj   +1 more source

Lack of protection following passive transfer of polyclonal highly functional low-dose non-neutralizing antibodies. [PDF]

PLoS ONE, 2014
Recent immune correlates analysis from the RV144 vaccine trial has renewed interest in the role of non-neutralizing antibodies in mediating protection from infection.
Anne-Sophie Dugast, Ying Chan, Michelle Hoffner, Anna Licht, Joseph Nkolola, Hualin Li, Hendrik Streeck, Todd J Suscovich, Musie Ghebremichael, Margaret E Ackerman, Dan H Barouch, Galit Alter   +11 more
doaj   +1 more source

Pan-Sarbecovirus Neutralizing Antibodies in BNT162b2-Immunized SARS-CoV-1 Survivors

New England Journal of Medicine, 2021
Summary Emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern pose a challenge to the effectiveness of current vaccines.
C. Tan, W. Chia, B. Young, Feng Zhu, B. Lim, W. Sia, T. Thein, M. Chen, Y. Leo, D. Lye, Lin‐Fa Wang   +10 more
semanticscholar   +1 more source