Results 41 to 50 of about 1,727,618 (310)

Generation of a protective murine monoclonal antibody against the stem of influenza hemagglutinins from group 1 viruses and identification of resistance mutations against it.

PLoS ONE, 2019
Vaccines that elicit broadly cross-neutralizing antibodies, including antibodies that target the conserved stem of hemagglutinin (HA), are being developed as a strategy for next-generation influenza vaccines that protect against influenza across multiple
Wei Wang, Russell Vassell, Hyo Sook Song, Qiong Chen, Paul W Keller, Swati Verma, Esmeralda Alvarado-Facundo, Hongquan Wan, Falko Schmeisser, Clement A Meseda, Jerry P Weir, Carol D Weiss   +11 more
doaj   +1 more source

Review of therapeutic mechanisms and applications based on SARS-CoV-2 neutralizing antibodies

Frontiers in Microbiology, 2023
COVID-19 pandemic is a global public health emergency. Despite extensive research, there are still few effective treatment options available today. Neutralizing-antibody-based treatments offer a broad range of applications, including the prevention and ...
Mingtao Liu, Hui Gan, Zhiman Liang, Li Liu, Qiwen Liu, Yiyin Mai, Huihuang Chen, Baoying Lei, Shangwei Yu, Huihui Chen, Peiyan Zheng, Baoqing Sun   +11 more
doaj   +1 more source

SnapShot: Broadly Neutralizing Antibodies

Cell, 2013
Durably elicited by live attenuated virus, less durably by inactivated virusConserved bnAb epitopes:1) Ep1 (res. 380–400) 2) Ep2 (res. 190–200)3) Ep3 (res. 571–579)Despite the extensive variability of measles virus, nAb responses to vaccination are broad becausethe conserved epitopes are immunoprominent.May relate to overlap of the receptor-binding ...
Brian Moldt, Devin Sok, Dennis R. Burton
openaire   +3 more sources

Infection with chikungunya virus confers heterotypic cross-neutralizing antibodies and memory B-cells against other arthritogenic alphaviruses predominantly through the B domain of the E2 glycoprotein.

PLoS Neglected Tropical Diseases, 2023
Infections with Chikungunya virus, a mosquito-borne alphavirus, cause an acute febrile syndrome often followed by chronic arthritis that persists for months to years post-infection.
John M Powers, Zoe L Lyski, Whitney C Weber, Michael Denton, Magdalene M Streblow, Adam T Mayo, Nicole N Haese, Chad D Nix, Rachel Rodríguez-Santiago, Luisa I Alvarado, Vanessa Rivera-Amill, William B Messer, Daniel N Streblow   +12 more
doaj   +1 more source

Potently neutralizing and protective human antibodies against SARS-CoV-2

Nature, 2020
The ongoing pandemic of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a major threat to global health1 and the medical countermeasures available so far are limited2,3.
Seth J. Zost, P. Gilchuk, J. Case, E. Binshtein, Rita E. Chen, Joseph P. Nkolola, A. Schäfer, Joseph X. Reidy, Andrew Trivette, Rachel S. Nargi, Rachel E. Sutton, Naveen Chandra Suryadevara, David R. Martinez, Lauren E. Williamson, E. Chen, Taylor Jones, Samuel B. Day, Luke Myers, Ahmed O. Hassan, Natasha M. Kafai, Emma S. Winkler, J. Fox, S. Shrihari, Benjamin K. Mueller, J. Meiler, A. Chandrashekar, N. Mercado, J. Steinhardt, K. Ren, Y. Loo, N. Kallewaard, B. McCune, Shamus P. Keeler, M. Holtzman, D. Barouch, Lisa E. Gralinski, R. Baric, Larissa B. Thackray, M. Diamond, R. Carnahan, J. Crowe   +40 more
semanticscholar   +1 more source

Antibody Profiling of Microbial Antigens in the Blood of COVID-19 mRNA Vaccine Recipients Using Microbial Protein Microarrays

Vaccines, 2023
Although studies have demonstrated that infections with various viruses, bacteria, and parasites can modulate the immune system, no study has investigated changes in antibodies against microbial antigens after the COVID-19 mRNA vaccination.
Hiroaki Saito, Hiroki Yoshimura, Makoto Yoshida, Yuta Tani, Moe Kawashima, Taiga Uchiyama, Tianchen Zhao, Chika Yamamoto, Yurie Kobashi, Toyoaki Sawano, Seiya Imoto, Hyeongki Park, Naotoshi Nakamura, Shingo Iwami, Yudai Kaneko, Aya Nakayama, Tatsuhiko Kodama, Masatoshi Wakui, Takeshi Kawamura, Masaharu Tsubokura   +19 more
doaj   +1 more source

Neutralization Interfering Antibodies: A “Novel” Example of Humoral Immune Dysfunction Facilitating Viral Escape?

Viruses, 2012
The immune response against some viral pathogens, in particular those causing chronic infections, is often ineffective notwithstanding a robust humoral neutralizing response.
Roberto Burioni, Laura Solforosi, Massimo Clementi, Roberta A. Diotti, Matteo Castelli, Elena Criscuolo, Nicola Clementi, Giuseppe Sautto, Mancini Nicasio   +8 more
doaj   +1 more source

Immune characterization of a Colombian family cluster with SARS-CoV-2 infection

Biomédica: revista del Instituto Nacional de Salud, 2021
Introduction: Immunological markers have been described during COVID-19 and persist after recovery. These immune markers are associated with clinical features among SARSCoV-2 infected individuals.
Wbeimar Aguilar-Jiménez, Lizdany Flórez-Álvarez, Daniel S. Rincón, Damariz Marín-Palma, Alexandra Sánchez-Martínez, Jahnnyer Martínez, María Isabel Zapata, John D. Loaiza, Constanza Cárdenas, Fanny Guzmán, Paula A. Velilla, Natalia A. Taborda, Wildeman Zapata, Juan C. Hernández, Francisco J. Díaz, María T. Rugeles   +15 more
doaj   +1 more source

Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies

Cellular & Molecular Immunology, 2020
Coronavirus disease 2019 (COVID-19), caused by the novel human coronavirus SARS-CoV-2, is currently a major threat to public health worldwide. The viral spike protein binds the host receptor angiotensin-converting enzyme 2 (ACE2) via the receptor-binding
C. Yi, Xiaoyu Sun, Jing Ye, Longfei Ding, Meiqin Liu, Zhuo Yang, Xiao Lu, Yaguang Zhang, Liyan Ma, Wangpeng Gu, Ai-dong Qu, Jianqing Xu, Zhènglì Shí, Z. Ling, Bing Sun   +14 more
semanticscholar   +1 more source

Continuous Delivery of Neutralizing Antibodies Elevate CCL2 Levels in Mice Bearing MCF10CA1d Breast Tumor Xenografts

Translational Oncology, 2017
Chemokines are small soluble molecules that play critical roles in wound healing, infection, and cancer progression. In particular, overexpression of the C-C motif chemokine ligand 2 (CCL2) in multiple cancer types correlates with poor patient prognosis.
Min Yao, Curtis Smart, Qingting Hu, Nikki Cheng   +3 more
doaj   +1 more source