Results 51 to 60 of about 1,849,608 (371)

Neutralization Interfering Antibodies: A “Novel” Example of Humoral Immune Dysfunction Facilitating Viral Escape?

Viruses, 2012
The immune response against some viral pathogens, in particular those causing chronic infections, is often ineffective notwithstanding a robust humoral neutralizing response.
Roberto Burioni, Laura Solforosi, Massimo Clementi, Roberta A. Diotti, Matteo Castelli, Elena Criscuolo, Nicola Clementi, Giuseppe Sautto, Mancini Nicasio   +8 more
doaj   +1 more source

Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies

Cellular & Molecular Immunology, 2020
Coronavirus disease 2019 (COVID-19), caused by the novel human coronavirus SARS-CoV-2, is currently a major threat to public health worldwide. The viral spike protein binds the host receptor angiotensin-converting enzyme 2 (ACE2) via the receptor-binding
C. Yi, Xiaoyu Sun, Jing Ye, Longfei Ding, Meiqin Liu, Zhuo Yang, Xiao Lu, Yaguang Zhang, Liyan Ma, Wangpeng Gu, Ai-dong Qu, Jianqing Xu, Zhènglì Shí, Z. Ling, Bing Sun   +14 more
semanticscholar   +1 more source

SARS-CoV-2 spike protein: a key target for eliciting persistent neutralizing antibodies

Signal Transduction and Targeted Therapy, 2021
A recent paper published in Science describes the detection of IgG antibody responses in individuals infected by severe acute respiratory syndrome coronavirus (SARS-CoV-2). The authors also examined the duration of antibody production and the correlation
Yang Yang, L. Du
semanticscholar   +1 more source

RSV Neutralizing Antibodies in Dried Blood

The Journal of Infectious Diseases, 2023
Abstract Background The key correlate of protection of respiratory syncytial virus (RSV) vaccines and monoclonal antibodies (mAbs) is virus neutralization, measured via sera obtained through venipuncture.
Jonne Terstappen, Eveline M Delemarre, Anouk Versnel, Joleen T White, Alexandrine Derrien-Colemyn, Tracy J Ruckwardt, Louis J Bont, Natalie I Mazur   +7 more
openaire   +4 more sources

Continuous Delivery of Neutralizing Antibodies Elevate CCL2 Levels in Mice Bearing MCF10CA1d Breast Tumor Xenografts

Translational Oncology, 2017
Chemokines are small soluble molecules that play critical roles in wound healing, infection, and cancer progression. In particular, overexpression of the C-C motif chemokine ligand 2 (CCL2) in multiple cancer types correlates with poor patient prognosis.
Min Yao, Curtis Smart, Qingting Hu, Nikki Cheng   +3 more
doaj   +1 more source

Discovery of neutralizing SARS-CoV-2 antibodies enriched in a unique antigen specific B cell cluster.

PLoS ONE, 2023
Despite development of effective SARS-CoV-2 vaccines, a sub-group of vaccine non-responders depends on therapeutic antibodies or small-molecule drugs in cases of severe disease.
Stine Sofie Frank Lende, Nanna Møller Barnkob, Randi Westh Hansen, Harsh Bansia, Mike Vestergaard, Frederik Holm Rothemejer, Anne Worsaae, Deijona Brown, Maria Lange Pedersen, Anna Halling Folkmar Rahimic, Anna Karina Juhl, Torben Gjetting, Lars Østergaard, Amédée Des Georges, Laurent-Michel Vuillard, Mariane Høgsbjerg Schleimann, Klaus Koefoed, Martin Tolstrup   +17 more
doaj   +1 more source

Broadly neutralizing antibodies target a haemagglutinin anchor epitope

Nature, 2021
Broadly neutralizing antibodies that target epitopes of haemagglutinin on the influenza virus have the potential to provide near universal protection against influenza virus infection1.
Jenna J. Guthmiller, Julianna Han, Henry A. Utset, Lei Li, L. Lan, Carole J Henry, Christopher T. Stamper, Meagan McMahon, George O’Dell, M. Fernández-Quintero, Alec W. Freyn, F. Amanat, O. Stovicek, Lauren E. Gentles, Sara T. Richey, A. T. de la Peña, Victoria C. Rosado, H. Dugan, Nai-Ying Zheng, Micah E. Tepora, Dalia J. Bitar, Siriruk Changrob, Shirin Strohmeier, Min Huang, A. García-Sastre, K. Liedl, J. Bloom, Raffael Nachbagauer, P. Palese, F. Krammer, Lynda Coughlan, A. Ward, P. Wilson   +32 more
semanticscholar   +1 more source

Glycan shifting on hepatitis C virus (HCV) E2 glycoprotein is a mechanism for escape from broadly neutralizing antibodies [PDF]

, 2013
Hepatitis C virus (HCV) infection is a major cause of liver disease and hepatocellular carcinoma. Glycan shielding has been proposed to be a mechanism by which HCV masks broadly neutralizing epitopes on its viral glycoproteins.
Adams, Alex Brown, Angus, Arvind H. Patel, Bartenschlager, Benedicto, Blight, Bradley, Broering, Bukh, Charles Eigenbrot, David Arnott, David J. Matthews, Dhillon, Diao, Emsley, Evans, Falkowska, Flint, Friebe, Gadgil, Gal-Tanamy, Giang, Goffard, Gordon, Helle, Helle, Herweijer, Homer Pantua, Hotzel, Iacob, Jingyu Diao, Jo-Anne Hongo, Kapadia, Kapadia, Kentaro Takeda, Kong, Kong, Krista McCutcheon, Lindenbach, Liu, Livak, Mark Ultsch, Mary Mathieu, McCaffrey, McCoy, Meredith Hazen, Moore, Murshudov, North, Otwinowski, Owsianka, Owsianka, Owsianka, Owsianka, Paborsky, Perotti, Phil Hass, Pikora, Pileri, Ploss, Potter, Qui Phung, Reed, Reesink, Robert F. Kelley, Sainz, Sarrazin, Scarselli, Shailesh Date, Sharookh B. Kapadia, Tommy K. Cheung, Trowbridge, Tsukiyama-Kohara, Utachee, Wang, Wei, Yi, Yi, Zhang, Zhang, Zhong   +81 more
core   +1 more source

Antibody neutralization of HIV-1

Immunology Today, 1996
Neutralizing antibodies are a major component of host defense against viruses, and appear to be particularly important in limiting the spread of cell-free virus. Results from vaccine trials in animal models suggest that these antibodies may contribute to protection against human immunodeficiency virus (HIV) infection.
Poignard, P, Klasse, P, Sattentau, Q
openaire   +2 more sources

Feline Immunodeficiency Virus (FIV) Neutralization: A Review

Viruses, 2011
One of the major obstacles that must be overcome in the design of effective lentiviral vaccines is the ability of lentiviruses to evolve in order to escape from neutralizing antibodies.
Margaret J. Hosie, Daniela Pajek, Brian J. Willett, Ayman Samman   +3 more
doaj   +1 more source