Results 61 to 70 of about 50,229 (188)

Functional compartmentalization of Rad9 and Hus1 reveals diverse assembly of the 9-1-1 complex components during the DNA damage response in Leishmania [PDF]

, 2016
The Rad9-Rad1-Hus1 (9-1-1) complex is a key component in the coordination of DNA damage sensing, cell cycle progression and DNA repair pathways in eukaryotic cells. This PCNA-related trimer is loaded onto RPA-coated single stranded DNA and interacts with
Damasceno, Jeziel D., McCulloch, Richard, Obonaga, Ricardo, Santos, Elaine V., Scott, Alan, Tosi, Luiz R.O.   +5 more
core   +1 more source

Leishmania donovani's protein tyrosine phosphatases interact with DUF21 and respond to environmental magnesium

The FEBS Journal, EarlyView.
The Leishmania phosphatase PTP1, and possibly the genetically similar PTP2, interacts with the Leishmania transmembrane protein DUF21. When both ptp1 and ptp2 are knocked out of Leishmania (LdΔPTP1/2), the parasite can no longer survive without magnesium in vitro and has reduced viability in the host macrophage. Conversely, in duf21 knockout (LdΔDUF21),
Kayla Paulini, Hira Khursheed, Wen Wei Zhang, Isabelle Aubry, Greg Matlashewski, Michel L. Tremblay, Patrick Lypaczewski   +6 more
wiley   +1 more source

Molecular mechanisms of drug resistance in natural Leishmania populations vary with genetic background [PDF]

, 2012
The evolution of drug-resistance in pathogens is a major global health threat. Elucidating the molecular basis of pathogen drug-resistance has been the focus of many studies but rarely is it known whether a drug-resistance mechanism identified is ...
A Debrabant, A Dube, A Mehta, A Mukherjee, AB Sidhu, AC Coelho, AH Fairlamb, Ashutosh, B Gourbal, B Vergnes, Basudha Khanal, BJ Mookerjee, C Brochu, C Dumas, CS Ferreira, D Legare, DM Weinreich, F Chappuis, F Frezard, G Mandal, Graham H. Coombs, H Denton, H Shim, Hideo Imamura, HW Murray, J Alvar, J Hellemans, J Mikus, J Tovar, JC Mottram, JC Munday, Jean-Claude Dujardin, JM Kelly, K Ait-Oudhia, K Grondin, KC Carter, Kirstyn Brunker, KW Tintaya, L Flohe, M Maharjan, M Samant, M Vanaerschot, Manu Vanaerschot, MK Mittal, ML Cunningham, MR Ariyanayagam, MR Perry, N Beerenwinkel, N Singh, N Van Meirvenne, P Baiocco, PJ Alcolea, PR Romao, R Hadighi, R Lira, R Mukhopadhyay, R Rojas, R Singh, RA Williams, RI da Luz, RL Krauth-Siegel, RL Krauth-Siegel, S Borrell, S Decuypere, S Dey, S Gagneux, S Mandal, S Muller, S Rais, S Rijal, S Sundar, S Wyllie, S Wyllie, S Yan, S Yan, Saskia Decuypere, Suman Rijal, Sylke Müller, T Downing, T Downing, T Laurent, T Nozaki, Timothy G. Geary, V Adaui, V Yardley, Y Zhou   +85 more
core   +4 more sources

TbTim20 facilitates protein import at a low membrane potential in trypanosomes lacking the mitochondrial genome

The FEBS Journal, EarlyView.
Protein import into mitochondria relies on TIM complexes and the membrane potential. Trypanosoma brucei has a unique TIM complex, and the role of one subunit, TbTim20, has remained unclear. Here, we show that TbTim20 is essential in cells lacking mitochondrial DNA. The importance of TbTim20 increases as the membrane potential decreases.
Corinne von Känel, Salome Aeschlimann, Michaela Husová, Silke Oeljeklaus, Philip Stettler, Achim Schnaufer, Bettina Warscheid, Alena Zíková, André Schneider   +8 more
wiley   +1 more source

Recombinant subunit vaccines against Neospora caninum [PDF]

, 2007
The intracellular protozoan parasite Neospora caninum is an important cause of bovine abortion and congenital infection in many countries. Currently there is no effective control method available, and development of a vaccine has been suggested as a ...
Pinitkiatisakul, Sunan
core  

A Novel Non-invasive Method to Detect RELM Beta Transcript in Gut Barrier Related Changes During a Gastrointestinal Nematode Infection [PDF]

, 2019
Currently, methods for monitoring changes of gut barrier integrity and the associated immune response via non-invasive means are limited. Therefore, we aimed to develop a novel non-invasive technique to investigate immunological host responses ...
Affinass, Nicole, Ahmed, Norus, Hartmann, Susanne, Heitlinger, Emanuel, Jarquin, Victor Hugo, Jost, Jenny, Kühl, Anja A., Steinfelder, Svenja, Xenophontos, Natasa   +8 more
core   +4 more sources

Screening for Trypanosoma cruzi infection (Chagas disease) in the Latin American population living with HIV in London

HIV Medicine, EarlyView.
Abstract Background There are an estimated 2482 people born in Latin American countries receiving care for HIV in the United Kingdom. Although national guidance recommends screening for Trypanosoma cruzi infection (Chagas disease) in this population, there is no formal screening programme.
Natalie Elkheir, Shivani Singh, Birgit Barbini, Lucy Campbell, Alice Sharp, Jacqueline O'Connell, Louise Terry, Margherita Bracchi, Javier Rubio, Nicolo Girometti, Mohammed Hassan, Hannah Davies, Frank A. Post, Laura Nabarro, Debbie Nolder, Geraldine O'Hara, Julie Fox, Peter L. Chiodini, David A. J. Moore   +18 more
wiley   +1 more source

Trans-sialidase delivered as a naked DNA vaccine elicits an immunological response similar to a Trypanosoma cruzi infection

Brazilian Journal of Medical and Biological Research, 1999
Trypanosoma cruzi, the protozoan parasite that causes Chagas' disease, does not synthesize sialic acid, but expresses a trans-sialidase (TS) that catalyzes the transfer of sialic acid from host glycoconjugates to the parasite surface.
F. Costa, V.L. Pereira-Chioccola, M. Ribeirão, S. Schenkman, M.M. Rodrigues   +4 more
doaj   +1 more source

Nanobodies as tools to understand, diagnose, and treat African trypanosomiasis [PDF]

, 2017
African trypanosomes are strictly extracellular protozoan parasites that cause diseases in humans and livestock and significantly affect the economic development of sub-Saharan Africa.
Caljon, Guy, De Baetselier, Patrick, Magez, Stefan, Stijlemans, Benoit, Van Den Abbeele, Jan, Van Ginderachter, Jo A   +5 more
core   +1 more source

Anticorpos anti-Neospora caninum em bovinos de leite do sudoeste do estado do Paraná

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2010
Since November 2007 until May 2009, 1,778 serum samples of cattle from dairy herds of the Southwest of Paraná State, Brazil, were used for search of anti-Neospora caninum antibodies. The frequency of seropositive animals, assessed by IFAT, was 24.2% (431/
G Camillo, G Cadore, A.S Cezar, G Toscan, P Bräunig, L.A Sangioni, F.S.F Vogel   +6 more
doaj   +1 more source