Results 121 to 130 of about 2,860,326 (352)

Beyond bNAbs: Uses, Risks, and Opportunities for Therapeutic Application of Non-Neutralising Antibodies in Viral Infection

Antibodies
The vast majority of antibodies generated against a virus will be non-neutralising. However, this does not denote an absence of protective capacity.
Kahlio Mader, Lynn B. Dustin
doaj   +1 more source

Neutralizing Antibodies and Pathogenesis of Hepatitis C Virus Infection

Viruses, 2012
Hepatitis C virus (HCV) infection is a major cause of chronic liver disease worldwide. The interplay between the virus and host innate and adaptive immune responses determines the outcome of infection.
Françoise Stoll-Keller, Thomas F. Baumert, Laura Heydmann, Isabel Fofana, Quentin Lepiller, Daniel J. Felmlee, Samira Fafi-Kremer, Mirjam B. Zeisel, Catherine Fauvelle   +8 more
doaj   +1 more source

Defining neutralization and allostery by antibodies against COVID-19 variants

Nature Communications, 2023
The changing landscape of SARS-CoV-2 Spike protein is linked to the emergence of variants, immune-escape and reduced efficacy of the existing repertoire of anti-viral antibodies.
Nikhil Kumar Tulsian, Raghuvamsi Venkata Palur, Xinlei Qian, Yue Gu, Bhuvaneshwari D/O Shunmuganathan, Firdaus Samsudin, Yee Hwa Wong, Jianqing Lin, Kiren Purushotorman, Mary McQueen Kozma, Bei Wang, Julien Lescar, Cheng-I Wang, Ravindra Kumar Gupta, Peter John Bond, Paul Anthony MacAry   +15 more
doaj   +1 more source

Antibodies to Enteroviruses in Cerebrospinal Fluid of Patients with Acute Flaccid Myelitis. [PDF]

, 2019
Acute flaccid myelitis (AFM) has caused motor paralysis in >560 children in the United States since 2014. The temporal association of enterovirus (EV) outbreaks with increases in AFM cases and reports of fever, respiratory, or gastrointestinal illness
Briese, Thomas, Burns, Jane C, Caciula, Adrian, Garcia, Joel A, Hetzler, Kimbell L, Jain, Komal, Konopka-Anstadt, Jennifer L, Lipkin, W Ian, Marine, Rachel L, Mishra, Nischay, Ng, James, Ng, Terry Fei Fan, Nix, W Allan, Oberste, M Steven, Price, Adam, Routh, Janell A, Thakkar, Riddhi, Thakkar, Roshni, Thakur, Kiran T, Tokarz, Rafal   +19 more
core   +2 more sources

Diagnosis and management of chronic viral hepatitis: Antigens, antibodies and viral genomes [PDF]

Best Practice & Research Clinical Gastroenterology, 2008
Virological tools, including serological and molecular tools, are needed to diagnose chronic hepatitis B and C infections. They may also be useful to establish their prognosis, but they have found their principal application in guiding treatment decisions and assessing the virological responses to therapy.
Chevaliez, Stéphane, Pawlotsky, Jean-Michel   +1 more
openaire   +3 more sources

Endoglin mediates the tumor‐ and metastasis‐promoting traits of stromal myofibroblasts in human breast carcinomas

Molecular Oncology, EarlyView.
Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo, Yoshihiro Mezawa, Zixu Wang, Ahmet Acar, Yasuhiko Ito, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Yataro Daigo, Takuya Shirakihara, Akira Orimo   +11 more
wiley   +1 more source

Respiratory antiviral immunity and immunobiotics: Beneficial effects on inflammation-coagulation interaction during influenza virus infection [PDF]

, 2016
Influenza virus (IFV) is a major respiratory pathogen of global importance, and the cause of a high degree of morbidity and mortality, especially in high-risk populations such as infants, elderly, and immunocompromised hosts.
Alvarez, Gladis Susana, Kitazawa, Haruki, Villena, Julio Cesar, Zelaya, María Hortensia del Rosario   +3 more
core   +1 more source

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

Epstein-Barr virus infections and DNA hybridization studies in posttransplantation lymphoma and lymphoproliferative lesions: The role of primary infection [PDF]

, 1985
Fourteen patients who developed B cell lymphomas or lymphoproliferative lesions after kidney, liver, heart, or heart-lung transplantation in Pittsburgh during 1981-1983 had active infection with Epstein-Barr virus (EBV)of the primary (six patients ...
Andiman, W, Atchison, RW, Bahnson, HT, Breinig, MK, Dummer, JS, Eastman, R, Griffith, BP, Hakala, TR, Hardesty, RL, Ho, M, Miller, G, Rosenthal, JT, Starzl, TE   +12 more
core   +1 more source

Virus-specific antibodies allow viral replication in the marginal zone, thereby promoting CD8+ T-cell priming and viral control

Scientific Reports, 2016
Clinically used human vaccination aims to induce specific antibodies that can guarantee long-term protection against a pathogen. The reasons that other immune components often fail to induce protective immunity are still debated.
Vikas Duhan, V. Khairnar, Sarah-Kim Friedrich, F. Zhou, A. Gassa, N. Honke, Namir Shaabani, Nicole Gailus, L. Botezatu, Cyrus Khandanpour, U. Dittmer, D. Häussinger, M. Recher, C. Hardt, P. Lang, K. Lang   +15 more
semanticscholar   +1 more source