Results 11 to 20 of about 10,579 (219)
Protective mechanisms of nonneutralizing antiviral antibodies.
PLoS Pathogens, 2023 Antibodies that can bind to viruses but are unable to block infection in cell culture are known as "nonneutralizing antibodies." Such antibodies are nearly universally elicited following viral infection and have been characterized in viral infections ...
Tawny L Chandler +4 more
doaj +1 more source
Viral antibodies in infectious mononucleosis [PDF]
FEMS Immunology & Medical Microbiology, 1994 Patients with Epstein-Barr virus (EBV) infectious mononucleosis (IM) usually develop heterophilic antibodies and some autoantibodies. Antibodies to rubella, measles, adeno-, entero-, herpes simplex, cytomegalo- and varicella-zoster viruses were titrated in sera from IM patients and matched healthy controls using the complement fixation test (CFT) and ...
May Britt Kalvenes +5 more
openaire +3 more sources
A joint Bayesian hierarchical model for estimating SARS-CoV-2 diagnostic and subgenomic RNA viral dynamics and seroconversion [PDF]
, 2023 Understanding the viral dynamics and immunizing antibodies of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for devising better therapeutic and prevention strategies for COVID-19. Here, we present a Bayesian hierarchical model that jointly estimates the diagnostic RNA viral load reflecting genomic materials of SARS-CoV-2 ...
arxiv +1 more source
Complete mapping of viral escape from neutralizing antibodies. [PDF]
PLoS Pathogens, 2017 Identifying viral mutations that confer escape from antibodies is crucial for understanding the interplay between immunity and viral evolution. We describe a high-throughput approach to quantify the selection that monoclonal antibodies exert on all ...
Michael B Doud +2 more
doaj +1 more source
Engineered antibodies to combat viral threats [PDF]
Nature, 2020 As the COVID-19 pandemic rages globally, interest in antiviral treatments has never been higher. Antibodies are key defence components, and engineering them to better exploit their natural functions might boost therapeutic options. Modification of the antibody Fc domain boosts defence responses.
Cragg, Mark, Yu, Xiaojie
openaire +4 more sources
Viral Antibodies in Chronic Fatigue Syndrome [PDF]
Clinical Infectious Diseases, 1995 Item does not contain ...
Swanink, C.M.A. +6 more
openaire +6 more sources
Microorganisms, 2021 The objective of the present study was to evaluate the true positivity among people, whose results of initial testing of nasopharyngeal swabs (NPS) showed a very low viral load of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Zoe Florou +7 more
doaj +1 more source
Viral interference with antibody and complement
Seminars in Cell & Developmental Biology, 1998 Viruses have evolved strategies to evade immunity mediated by antibody and complement. Herpesviruses and coronaviruses encode IgG Fc binding proteins that inhibit IgG activity, enabling the virus or infected cell to escape antibody attack. Herpesviruses, vaccinia virus and HIV-1 have the capacity to interfere with complement, either by incorporation of
Harvey M. Friedman +2 more
openaire +2 more sources
Antibody barriers to going viral [PDF]
Journal of Experimental Medicine, 2019 Antibody neutralization of a virus in vitro is often associated with protection against viral exposure in vivo, but the mechanisms operational in vivo are often unclear. By investigating a large number of antibodies, Earnest et al. (https://doi.org/10.1084/jem.20190736) show the importance of antibody effector function in neutralizing antibody ...
openaire +2 more sources
Phenotypic continuum of NFU1‐related disorders
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 2025-2035, December 2022., 2022 Abstract Bi‐allelic variants in Iron–Sulfur Cluster Scaffold (NFU1) have previously been associated with multiple mitochondrial dysfunctions syndrome 1 (MMDS1) characterized by early‐onset rapidly fatal leukoencephalopathy. We report 19 affected individuals from 10 independent families with ultra‐rare bi‐allelic NFU1 missense variants associated with a
Rauan Kaiyrzhanov +45 more
wiley +1 more source