Results 21 to 30 of about 10,579 (219)

Production of the Receptor-binding Domain of the Viral Spike Proteins from 2003 and 2019 SARS CoVs and the Four Common Human Coronaviruses for Serologic Assays and Inhibitor Screening

Bio-Protocol, 2021
The recombinant receptor-binding domain (RBD) of the viral spike protein from SARS-CoV-1 and 2 are reliable antigens for detecting viral-specific antibodies in humans.
Bruno Segovia-Chumbez, Stephen Graham, Ramesh Jadi, Aravinda de Silva, Lakshmanane Premkumar   +4 more
doaj   +1 more source

Antibody response against selected epitopes in the HIV-1 envelope gp41 ectodomain contributes to reduce viral burden in HIV-1 infected patients

Scientific Reports, 2021
The ectodomain of gp41 is the target of potent binding and neutralizing antibodies (NAbs) and is being explored in new strategies for antibody-based HIV vaccines. Previous studies have suggested that the W164A-3S (3S) and EC26-2A4 (EC26) peptides located
Rute Marcelino, Filipa Gramacho, Francisco Martin, Pedro Brogueira, Nuno Janeiro, Claudia Afonso, Robert Badura, Emília Valadas, Kamal Mansinho, Luís Caldeira, Nuno Taveira, José M. Marcelino   +11 more
doaj   +1 more source

Predicting in vivo escape dynamics of HIV-1 from a broadly neutralizing antibody [PDF]

, 2020
Broadly neutralizing antibodies are promising candidates for treatment and prevention of HIV-1 infections. Such antibodies can temporarily suppress viral load in infected individuals; however, the virus often rebounds by escape mutants that have evolved resistance.
arxiv   +1 more source

The Vestigial Esterase Domain of Haemagglutinin of H5N1 Avian Influenza A Virus: Antigenicity and Contribution to Viral Pathogenesis

Vaccines, 2018
Initial attempts to develop monoclonal antibodies as therapeutics to resolve influenza infections focused mainly on searching for antibodies with the potential to neutralise the virus in vitro with classical haemagglutination inhibition and ...
Zhiqiang Zheng, Subha Sankar Paul, Xiaobing Mo, Yu-Ren Adam Yuan, Yee-Joo Tan   +4 more
doaj   +1 more source

Interleukins as one of possible markers for early diagnosis of viral hepatitis c at first year old children

Журнал инфектологии, 2014
The article presents the results of the research of improvement one of possible methods of early diagnostics of viral hepatitis C at first-year old children, who born from mothers with chronic viral hepatitis C, in blood anti-HCV IgG are revealed, based ...
T. A. Kirsanova
doaj   +1 more source

Virological and Serological Discordant Profiles in COVID-19 Pneumonia: Two Atypical Clinical Cases

Frontiers in Immunology, 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is primarily diagnosed through viral RNA positivity in nasopharyngeal swabs, and it is associated with the early detection of specific immunoglobulins to SARS-CoV-2 proteins.
Martina Ranzenigo, Claudia Pastori, Gabriel Siracusano, Elena Pariani, Caterina Uberti-Foppa, Lucia Lopalco   +5 more
doaj   +1 more source

A Novel, Comprehensive A129 Mouse Model for Investigating Dengue Vaccines and Evaluating Pathogenesis

Vaccines, 2023
In search of a mouse model for use in evaluating dengue vaccines, we assessed A129 mice that lacked IFN-α/β receptors, rendering them susceptible to dengue virus (DENV) infection.
Mya Myat Ngwe Tun, Khine Mya Nwe, Jean Claude Balingit, Yuki Takamatsu, Shingo Inoue, Basu Dev Pandey, Takeshi Urano, Michinori Kohara, Kyoko Tsukiyama-Kohara, Kouichi Morita   +9 more
doaj   +1 more source

Shape Complementarity Optimization of Antibody-Antigen Interfaces: the Application to SARS-CoV-2 Spike Protein [PDF]

, 2021
Many factors influence biomolecules binding, and its assessment constitutes an elusive challenge in computational structural biology. In this respect, the evaluation of shape complementarity at molecular interfaces is one of the main factors to be considered.
arxiv   +1 more source

Unbiased interrogation of memory B cells from convalescent COVID-19 patients reveals a broad antiviral humoral response targeting SARS-CoV-2 antigens beyond the spike protein

Vaccine: X, 2021
Patients who recover from SARS-CoV-2 infections produce antibodies and antigen-specific T cells against multiple viral proteins. Here, an unbiased interrogation of the anti-viral memory B cell repertoire of convalescent patients has been performed by ...
Jillian M. DiMuzio, Baron C. Heimbach, Raymond J. Howanski, John P. Dowling, Nirja B. Patel, Noeleya Henriquez, Chris Nicolescu, Mitchell Nath, Antonio Polley, Jamie L. Bingaman, Todd Smith, Benjamin C. Harman, Matthew K. Robinson, Michael J. Morin, Pavel A. Nikitin   +14 more
doaj  

A Broadly Reactive Human Anti-hemagglutinin Stem Monoclonal Antibody That Inhibits Influenza A Virus Particle Release

EBioMedicine, 2017
Many broadly reactive human monoclonal antibodies against the hemagglutinin (HA) stem of influenza A virus have been developed for therapeutic applications.
Seiya Yamayoshi, Ryuta Uraki, Mutsumi Ito, Maki Kiso, Sumiho Nakatsu, Atsuhiro Yasuhara, Kohei Oishi, Tadahiro Sasaki, Kazuyoshi Ikuta, Yoshihiro Kawaoka   +9 more
doaj   +1 more source