Results 21 to 30 of about 288,682 (209)

A new subunit vaccine based on nucleoprotein nanoparticles confers partial clinical and virological protection in calves against bovine respiratory syncytial virus [PDF]

, 2010
Human and bovine respiratory syncytial viruses (HRSV and BRSV) are two closely related, worldwide prevalent viruses that are the leading cause of severe airway disease in children and calves, respectively.
Bernadet, Philippe, Bernard, Julie, Bernex, Florence, Castagné, Nathalie, Deplanche, Martine, Deville, Sébastien, Dubosclard, Virginie, Dubuquoy, Catherine, Durand, Guillaume, Eléouët, Jean-François, Meyer, Gilles, Petit-Camurdan, Agnès, Riffault, Sabine, Schwartz-Cornil, Isabelle, Soulestin, Marion   +14 more
core   +2 more sources

The Vestigial Esterase Domain of Haemagglutinin of H5N1 Avian Influenza A Virus: Antigenicity and Contribution to Viral Pathogenesis

Vaccines, 2018
Initial attempts to develop monoclonal antibodies as therapeutics to resolve influenza infections focused mainly on searching for antibodies with the potential to neutralise the virus in vitro with classical haemagglutination inhibition and ...
Zhiqiang Zheng, Subha Sankar Paul, Xiaobing Mo, Yu-Ren Adam Yuan, Yee-Joo Tan   +4 more
doaj   +1 more source

Production of the Receptor-binding Domain of the Viral Spike Proteins from 2003 and 2019 SARS CoVs and the Four Common Human Coronaviruses for Serologic Assays and Inhibitor Screening

Bio-Protocol, 2021
The recombinant receptor-binding domain (RBD) of the viral spike protein from SARS-CoV-1 and 2 are reliable antigens for detecting viral-specific antibodies in humans.
Bruno Segovia-Chumbez, Stephen Graham, Ramesh Jadi, Aravinda de Silva, Lakshmanane Premkumar   +4 more
doaj   +1 more source

Single-domain antibodies and their formatting to combat viral infections [PDF]

, 2018
Since their discovery in the 1990s, single-domain antibodies (VHHs), also known as NanobodiesA (R), have changed the landscape of affinity reagents. The outstanding solubility, stability, and specificity of VHHs, as well as their small size, ease of ...
Ballegeer, Marlies, De Vlieger, Dorien, Rossey, Iebe, Saelens, Xavier, Schepens, Bert   +4 more
core   +2 more sources

Antibody therapies for the prevention and treatment of viral infections

npj Vaccines, 2017
Antibodies are an important component in host immune responses to viral pathogens. Because of their unique maturation process, antibodies can evolve to be highly specific to viral antigens.
Georgina Salazar, Ningyan Zhang, Tong-Ming Fu, Zhiqiang An   +3 more
doaj   +1 more source

Interleukins as one of possible markers for early diagnosis of viral hepatitis c at first year old children

Журнал инфектологии, 2014
The article presents the results of the research of improvement one of possible methods of early diagnostics of viral hepatitis C at first-year old children, who born from mothers with chronic viral hepatitis C, in blood anti-HCV IgG are revealed, based ...
T. A. Kirsanova
doaj   +1 more source

Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape pathways

iScience, 2022
Summary: The rapid spread of SARS-CoV-2 variants poses a constant threat of escape from monoclonal antibody and vaccine countermeasures. Mutations in the ACE2 receptor binding site on the surface S protein have been shown to disrupt antibody binding and ...
Fangzhu Zhao, Celina Keating, Gabriel Ozorowski, Namir Shaabani, Irene M. Francino-Urdaniz, Shawn Barman, Oliver Limbo, Alison Burns, Panpan Zhou, Michael J. Ricciardi, Jordan Woehl, Quoc Tran, Hannah L. Turner, Linghang Peng, Deli Huang, David Nemazee, Raiees Andrabi, Devin Sok, John R. Teijaro, Timothy A. Whitehead, Andrew B. Ward, Dennis R. Burton, Joseph G. Jardine   +22 more
doaj   +1 more source

Mutations in the Schmallenberg virus Gc glycoprotein facilitate cellular protein synthesis shutoff and restore pathogenicity of NSs deletion mutants in mice [PDF]

, 2016
Serial passage of viruses in cell culture has been traditionally used to attenuate virulence and identify determinants of viral pathogenesis. In a previous study, we found that a strain of Schmallenberg virus (SBV) serially passaged in tissue culture ...
Aislynn Taggart, Anna Janowicz, BMJ Group, Frauke Seehusen, Ilaria M. Piras, Kerstin Hahn, Marco Caporale, Mariana Varela, Massimo Palmarini, Rute Maria Pinto, S. López, William Marciel de Souza, Wolfgang Baumgärtner, Xiaohong Shi   +13 more
core   +1 more source

Implications of immune responses to DENV, JEV, and ZIKV Infections for cross-reactivity and considerations for vaccine evaluation

Virus Research
Dengue virus (DENV), Japanese encephalitis virus (JEV), and Zika virus (ZIKV) are mosquito-borne flaviviruses of global concern, causing illnesses ranging from mild fever to severe neurological or hemorrhagic disease.
Thi Thanh Ngan Nguyen, Mya Myat Ngwe Tun, Thi Bich Hau Vu, Thi Thu Thuy Nguyen, Vu Mai Phuong Hoang, Le Khanh Hang Nguyen, Trong Lan Phan, Duc Anh Dang, Muhareva Raekiansyah, Ryosuke Suzuki, Jean Claude Balingit, Yuki Takamatsu, Corazon C. Buerano, Takeshi Urano, Thi Quynh Mai Le, Futoshi Hasebe, Kouichi Morita   +16 more
doaj   +1 more source

Virological and Serological Discordant Profiles in COVID-19 Pneumonia: Two Atypical Clinical Cases

Frontiers in Immunology, 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is primarily diagnosed through viral RNA positivity in nasopharyngeal swabs, and it is associated with the early detection of specific immunoglobulins to SARS-CoV-2 proteins.
Martina Ranzenigo, Claudia Pastori, Gabriel Siracusano, Elena Pariani, Caterina Uberti-Foppa, Lucia Lopalco   +5 more
doaj   +1 more source