Results 31 to 40 of about 2,860,326 (352)

Behaviour of non-donor specific antibodies during rapid re-synthesis of donor specific HLA antibodies after antibody incompatible renal transplantation [PDF]

, 2013
Background: HLA directed antibodies play an important role in acute and chronic allograft rejection. During viral infection of a patient with HLA antibodies, the HLA antibody levels may rise even though there is no new immunization with antigen ...
Briggs, David, Dr., Daga, Sunil, Hamer, Rizwan, Higgins, Rob, Imray, C. (Chris), Kashi, Habib, Krishnan, Nithya S., Lam, F. T., Lowe, David Philip, Raymond, Neil T., Tan, Lam Chin, Zehnder, Daniel   +11 more
core   +2 more sources

Comprehensive mapping of mutations to the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human serum antibodies

bioRxiv, 2021
The evolution of SARS-CoV-2 could impair recognition of the virus by human antibody-mediated immunity. To facilitate prospective surveillance for such evolution, we map how convalescent serum antibodies are impacted by all mutations to the spike’s ...
Allison J. Greaney, Andrea N. Loes, K. H. Crawford, Tyler N. Starr, Keara D. Malone, H. Chu, J. Bloom   +6 more
semanticscholar   +1 more source

Antibody barriers to going viral [PDF]

Journal of Experimental Medicine, 2019
Antibody neutralization of a virus in vitro is often associated with protection against viral exposure in vivo, but the mechanisms operational in vivo are often unclear. By investigating a large number of antibodies, Earnest et al. (https://doi.org/10.1084/jem.20190736) show the importance of antibody effector function in neutralizing antibody ...
openaire   +2 more sources

Functional stability of HIV-1 envelope trimer affects accessibility to broadly neutralizing antibodies at its apex [PDF]

, 2017
The trimeric envelope glycoprotein spike (Env) of HIV-1 is the target of vaccine development to elicit broadly neutralizing antibodies (bnAbs). Env trimer instability and heterogeneity in principle make subunit interfaces inconsistent targets for the ...
Gift, Syna Kuriakose, Kim, Arthur S, Leaman, Daniel P, Zhang, Lei, Zwick, Michael B   +4 more
core   +2 more sources

A Novel, Comprehensive A129 Mouse Model for Investigating Dengue Vaccines and Evaluating Pathogenesis

Vaccines, 2023
In search of a mouse model for use in evaluating dengue vaccines, we assessed A129 mice that lacked IFN-α/β receptors, rendering them susceptible to dengue virus (DENV) infection.
Mya Myat Ngwe Tun, Khine Mya Nwe, Jean Claude Balingit, Yuki Takamatsu, Shingo Inoue, Basu Dev Pandey, Takeshi Urano, Michinori Kohara, Kyoko Tsukiyama-Kohara, Kouichi Morita   +9 more
doaj   +1 more source

A new subunit vaccine based on nucleoprotein nanoparticles confers partial clinical and virological protection in calves against bovine respiratory syncytial virus [PDF]

, 2010
Human and bovine respiratory syncytial viruses (HRSV and BRSV) are two closely related, worldwide prevalent viruses that are the leading cause of severe airway disease in children and calves, respectively.
Bernadet, Philippe, Bernard, Julie, Bernex, Florence, Castagné, Nathalie, Deplanche, Martine, Deville, Sébastien, Dubosclard, Virginie, Dubuquoy, Catherine, Durand, Guillaume, Eléouët, Jean-François, Meyer, Gilles, Petit-Camurdan, Agnès, Riffault, Sabine, Schwartz-Cornil, Isabelle, Soulestin, Marion   +14 more
core   +2 more sources

Antibody response against selected epitopes in the HIV-1 envelope gp41 ectodomain contributes to reduce viral burden in HIV-1 infected patients

Scientific Reports, 2021
The ectodomain of gp41 is the target of potent binding and neutralizing antibodies (NAbs) and is being explored in new strategies for antibody-based HIV vaccines. Previous studies have suggested that the W164A-3S (3S) and EC26-2A4 (EC26) peptides located
Rute Marcelino, Filipa Gramacho, Francisco Martin, Pedro Brogueira, Nuno Janeiro, Claudia Afonso, Robert Badura, Emília Valadas, Kamal Mansinho, Luís Caldeira, Nuno Taveira, José M. Marcelino   +11 more
doaj   +1 more source

The enzymes LSD1 and Set1A cooperate with the viral protein HBx to establish an active hepatitis B viral chromatin state [PDF]

, 2016
Indexación: Web of ScienceWith about 350 million people chronically infected around the world hepatitis B is a major health problem. Template for progeny HBV synthesis is the viral genome, organized as a minichromosome (cccDNA) inside the hepatocyte ...
Alarcon, V, Alvarez, F, De Ferrari, GV, Flores, Y, Hernandez, S, Kann, M, Loyola, A, Rubio, L, Varas-Godoy, M, Villanueva, RA   +9 more
core   +2 more sources

Combination therapy with anti-HIV-1 antibodies maintains viral suppression

Nature, 2018
Individuals infected with HIV-1 require lifelong antiretroviral therapy, because interruption of treatment leads to rapid rebound viraemia. Here we report on a phase 1b clinical trial in which a combination of 3BNC117 and 10-1074, two potent monoclonal ...
Pilar Mendoza, H. Gruell, Lilian Nogueira, J. Pai, Allison L. Butler, Katrina G. Millard, C. Lehmann, I. Suárez, Thiago Y. Oliveira, J. C. Lorenzi, Yehuda Z. Cohen, C. Wyen, T. Kümmerle, Theodora Karagounis, Ching-Lan Lu, L. Handl, Cecilia Unson-O’Brien, R. Patel, Carola Ruping, M. Schlotz, M. Witmer-Pack, I. Shimeliovich, G. Kremer, E. Thomas, K. Seaton, Jill Horowitz, A. West, P. Bjorkman, G. Tomaras, R. Gulick, N. Pfeifer, G. Fätkenheuer, M. Seaman, F. Klein, M. Caskey, M. Nussenzweig   +35 more
semanticscholar   +1 more source

Epidemiological evidence of acute transmission of Zika virus infection in dengue suspected patients in Sri-Lanka

Journal of Infection and Public Health, 2023
Background: Zika Virus (ZIKV) is a re-emerging, arthropod-borne flavivirus transmitted by Aedes mosquitoes (Ae. aegypti and Ae. albopictus). The coexistence of dengue virus (DENV) and ZIKV concurrently has been associated with a wide array of ...
Mya Myat Ngwe Tun, Sandra Kendra Raini, Lakkumar Fernando, YINS Gunawardene, Shingo Inoue, Yuki Takamatsu, Takeshi Urano, Rohitha Muthugala, Menaka Hapugoda, Kouichi Morita   +9 more
doaj   +1 more source