Results 31 to 40 of about 10,579 (219)

Novel ACE2 fusion protein with adapting activity against SARS-CoV-2 variants in vitro

Frontiers in Immunology, 2023
Despite the successful development of vaccines and neutralizing antibodies to limit the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerging variants prolong the pandemic and emphasize the persistent need to develop effective ...
Latifa Zekri, Latifa Zekri, Latifa Zekri, Latifa Zekri, Natalia Ruetalo, Mary Christie, Carolin Walker, Carolin Walker, Timo Manz, Timo Manz, Hans-Georg Rammensee, Hans-Georg Rammensee, Hans-Georg Rammensee, Helmut R. Salih, Helmut R. Salih, Helmut R. Salih, Michael Schindler, Gundram Jung, Gundram Jung, Gundram Jung   +19 more
doaj   +1 more source

Humoral and Mucosal Antibody Response to RSV Structural Proteins in RSV-Infected Adult Hematopoietic Cell Transplant (HCT) Recipients

Viruses, 2021
Respiratory syncytial virus (RSV) is an important cause of lower respiratory tract infection in infants, the elderly, and immunocompromised patients. RSV antibodies play a role in preventing reinfection and in clearance of RSV, but data regarding the ...
Xunyan Ye, Obinna P. Iwuchukwu, Vasanthi Avadhanula, Letisha O. Aideyan, Trevor J. McBride, David M. Henke, Kirtida D. Patel, Felipe-Andres Piedra, Laura S. Angelo, Dimpy P. Shah, Roy F. Chemaly, Pedro A. Piedra   +11 more
doaj   +1 more source

Modeling COVID-19 vaccine-induced immunological memory development and its links to antibody level and infectiousness [PDF]

arXiv, 2022
COVID-19 vaccines have proven to be effective against SARS-CoV-2 infection. However, the dynamics of vaccine-induced immunological memory development and neutralizing antibodies generation are not fully understood, limiting vaccine development and vaccination regimen determination. Herein, we constructed a mathematical model to characterize the vaccine-
arxiv  

Global properties of an age-structured virus model with saturated antibody immune response, multi-target cells and general incidence rate [PDF]

Bolet\'in de la Sociedad Matem\'atica Mexicana, Vol. 27 (2021) 26, 2017
Some viruses, such as human immunodeficiency virus, can infect several types of cell populations. The age of infection can also affect the dynamics of infected cells and production of viral particles. In this work, we study a virus model with infection-age and different types of target cells which takes into account the saturation effect in antibody ...
arxiv   +1 more source

Antibody response to a viral transcriptional regulator

FEBS Letters, 2002
The E2 transcriptional activator of the human papillomavirus regulates the expression of most viral transcripts. Its binding to specific target DNA sequences involves large conformational changes in the interacting macromolecules. The high stability of the E2:DNA complex prompted us to analyze the role of macromolecular interactions and adjuvant ...
Cerutti, Maria Laura, Centeno, Juan M., de Prat Gay, Gonzalo, Goldbaum, Fernando Alberto   +3 more
openaire   +4 more sources

Viral antibodies in bovine fetuses in Argentina

Research in Veterinary Science, 1993
In order to establish the prevalence of viral infections of the bovine fetus in Argentina, a serological survey for antibodies against viral agents currently affecting cattle in this country was conducted. Antibodies against foot-and-mouth disease virus (FMDV), bovine herpesvirus-1 (BHV-1), bovine leukaemia virus (BLV), bovine rotavirus (BRV), bovine ...
A.A. Schudel, E. Ulloa, I.A. Lager, G.B. Pinto, E.L. Weber, P. Hawkes, O Zabal   +6 more
openaire   +3 more sources

Accurate Prediction of Antibody Function and Structure Using Bio-Inspired Antibody Language Model [PDF]

arXiv, 2023
In recent decades, antibodies have emerged as indispensable therapeutics for combating diseases, particularly viral infections. However, their development has been hindered by limited structural information and labor-intensive engineering processes. Fortunately, significant advancements in deep learning methods have facilitated the precise prediction ...
arxiv  

Influenza Virus-cell Fusion Inhibition Assay

Bio-Protocol, 2013
During viral infection to host cells, several viruses undergo the process of endocytosis and pH-dependent fusion. By fusion of viral membrane with host cellular membrane, the viral core invades to host cytoplasm.
Mayo Yasugi, Kazuyoshi Ikuta
doaj   +1 more source

A model of virus infection with immune responses supports boosting CTL response to balance antibody response [PDF]

arXiv, 2022
We analyze a within-host model of virus infection with antibody and CD8+ cytotoxic T lymphocyte (CTL) responses proposed by Schwartz et al. (2013). The goal of this work is to gain an overview of the stability of the biologically-relevant equilibria as a function of the model's immune response parameters. We show that the equilibria undergo at most two
arxiv  

Post-Immune Antibodies in HIV-1 Infection in the Context of Vaccine Development: A Variety of Biological Functions and Catalytic Activities

Vaccines, 2022
Unlike many other viruses, HIV-1 is highly variable. The structure of the viral envelope changes as the infection progresses and is one of the biggest obstacles in developing an HIV-1 vaccine.
Anna Timofeeva, Sergey Sedykh, Georgy Nevinsky   +2 more
doaj   +1 more source