Results 41 to 50 of about 2,860,326 (352)

Safety and anti-viral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals

Nature Network Boston, 2018
Monotherapy of HIV-1 infection with single antiretroviral agents is ineffective because error-prone HIV-1 replication leads to the production of drug-resistant viral variants1,2.
Y. Bar-On, H. Gruell, T. Schoofs, J. Pai, Lilian Nogueira, Allison L. Butler, Katrina G. Millard, C. Lehmann, I. Suárez, Thiago Y. Oliveira, Theodora Karagounis, Yehuda Z. Cohen, C. Wyen, S. Scholten, L. Handl, Shiraz A. Belblidia, Juan P Dizon, J. Vehreschild, M. Witmer-Pack, I. Shimeliovich, Kanika Jain, Kerstin Fiddike, K. Seaton, N. Yates, Jill Horowitz, R. Gulick, N. Pfeifer, G. Tomaras, M. Seaman, G. Fätkenheuer, M. Caskey, F. Klein, M. Nussenzweig   +32 more
semanticscholar   +1 more source

Production of the Receptor-binding Domain of the Viral Spike Proteins from 2003 and 2019 SARS CoVs and the Four Common Human Coronaviruses for Serologic Assays and Inhibitor Screening

Bio-Protocol, 2021
The recombinant receptor-binding domain (RBD) of the viral spike protein from SARS-CoV-1 and 2 are reliable antigens for detecting viral-specific antibodies in humans.
Bruno Segovia-Chumbez, Stephen Graham, Ramesh Jadi, Aravinda de Silva, Lakshmanane Premkumar   +4 more
doaj   +1 more source

The Vestigial Esterase Domain of Haemagglutinin of H5N1 Avian Influenza A Virus: Antigenicity and Contribution to Viral Pathogenesis

Vaccines, 2018
Initial attempts to develop monoclonal antibodies as therapeutics to resolve influenza infections focused mainly on searching for antibodies with the potential to neutralise the virus in vitro with classical haemagglutination inhibition and ...
Zhiqiang Zheng, Subha Sankar Paul, Xiaobing Mo, Yu-Ren Adam Yuan, Yee-Joo Tan   +4 more
doaj   +1 more source

Identification of hepatitis a virus mimotopes by phage display, antigenicity and immunogenicity [PDF]

, 2007
A phage-displayed peptide approach was used to identify ligands mimicking antigenic determinants of hepatitis A virus (HAV) for the first time. Bacteriophages displaying HAV mimotopes were isolated from a phage-display peptide library by affinity ...
Alicia Aguilar, Altschul, Arturo Talavera, Beales, Beckmann, Bosch, Burritt, Burritt, Clark, Cohen, Collins, Cuthbert, David I. Stott, de la Cruz, Delmastro, Ela M. Perez, Emini, Enshell-Seijffers, Felici, Folgori, Folgori, Frank Camacho, Gomara, Hollinger, Hoogenboon, Irving, Lemon, Lemon, Lemon, Lemon, Lemon, Lemon, Marston, Martin, Mattioli, Nainan, Neduva, Nevis Amin, Osmany G. Larralde, Partidos, Perea, Perez, Ping, Ping, Prezzi, Raiza Martinez, Reed, Sambrook, Scholfield, Stapleton, Stapleton, Stapleton, Verdaguer, Wan, Zhang   +54 more
core   +1 more source

Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine

Cellular & Molecular Immunology, 2020
The outbreak of Coronavirus Disease 2019 (COVID-19) has posed a serious threat to global public health, calling for the development of safe and effective prophylactics and therapeutics against infection of its causative agent, severe acute respiratory ...
Wanbo Tai, Lei He, Xiujuan Zhang, J. Pu, D. Voronin, Shibo Jiang, Yusen Zhou, L. Du   +7 more
semanticscholar   +1 more source

Effect of Bamlanivimab as Monotherapy or in Combination With Etesevimab on Viral Load in Patients With Mild to Moderate COVID-19: A Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2021
Importance Coronavirus disease 2019 (COVID-19) continues to spread rapidly worldwide. Neutralizing antibodies are a potential treatment for COVID-19.
R. Gottlieb, A. Nirula, Peter Chen, J. Boscia, B. Heller, J. Morris, G. Huhn, Jose Cardona, Bharat Mocherla, V. Stosor, Imad Shawa, Princy N. Kumar, A. Adams, Jacob Van Naarden, Kenneth L Custer, M. Durante, G. Oakley, A. Schade, T. Holzer, P. Ebert, R. Higgs, N. Kallewaard, J. Sabo, D. Patel, P. Klekotka, Lei-Bin Shen, D. Skovronsky   +26 more
semanticscholar   +1 more source

Protection and mechanism of action of a novel human respiratory syncytial virus vaccine candidate based on the extracellular domain of small hydrophobic protein [PDF]

, 2014
Infections with human respiratory syncytial virus (HRSV) occur globally in all age groups and can have devastating consequences in young infants. We demonstrate that a vaccine based on the extracellular domain (SHe) of the small hydrophobic (SH) protein ...
Bert Schepens, Brian Gilbert, Cherrie AH, Connors M, Glezen WP, Kenny Roose, Koen Sedeyn, Liesbeth Vande Ginste, Lieselot Houspie, Marc Van Ranst, Michael Schotsaert, Mills JT, Nicholas JA, Nico Rooijen, Olmsted RA, Pedro Piedra, Sarah De Baets, Ventre K, Walter Fiers, Whitehead SS, Xavier Saelens   +20 more
core   +3 more sources

Antibody therapies for the prevention and treatment of viral infections

npj Vaccines, 2017
Antibodies are an important component in host immune responses to viral pathogens. Because of their unique maturation process, antibodies can evolve to be highly specific to viral antigens.
Georgina Salazar, Ningyan Zhang, Tong-Ming Fu, Zhiqiang An   +3 more
doaj   +1 more source

Interleukins as one of possible markers for early diagnosis of viral hepatitis c at first year old children

Журнал инфектологии, 2014
The article presents the results of the research of improvement one of possible methods of early diagnostics of viral hepatitis C at first-year old children, who born from mothers with chronic viral hepatitis C, in blood anti-HCV IgG are revealed, based ...
T. A. Kirsanova
doaj   +1 more source

High prevalence of antibodies to human herpesvirus 8 in relatives of patients with classic Kaposi's sarcoma from Sardinia [PDF]

, 1998
A survey for antibodies to a recombinant small viral capsid antigen (sVCA) of human herpesvirus type 8 (HHV‐8) was conducted in Sardinia, one of the world's highest incidence areas for classic Kaposi's sarcoma (KS). Prevalence of antibodies to HHV‐8 sVCA
Angeloni, Antonio, Cerimele, Decio, Cottoni, Francesca Maria Giovanna, Faggioni, Alberto, Heston, Lee, Lin, Su-Fang, Masala, Maria Vittoria, Miller, George, Rigsby, Michael, Sirianni, Maria Caterina, Sun, Ren, Uccini, Stefania   +11 more
core   +1 more source