Results 61 to 70 of about 732,545 (316)

Epidemiological evidence of acute transmission of Zika virus infection in dengue suspected patients in Sri-Lanka

Journal of Infection and Public Health, 2023
Background: Zika Virus (ZIKV) is a re-emerging, arthropod-borne flavivirus transmitted by Aedes mosquitoes (Ae. aegypti and Ae. albopictus). The coexistence of dengue virus (DENV) and ZIKV concurrently has been associated with a wide array of ...
Mya Myat Ngwe Tun, Sandra Kendra Raini, Lakkumar Fernando, YINS Gunawardene, Shingo Inoue, Yuki Takamatsu, Takeshi Urano, Rohitha Muthugala, Menaka Hapugoda, Kouichi Morita   +9 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Complement-Mediated Virus Infectivity Neutralisation by HLA Antibodies Is Associated with Sterilising Immunity to SIV Challenge in the Macaque Model for HIV/AIDS. [PDF]

, 2014
Sterilising immunity is a desired outcome for vaccination against human immunodeficiency virus (HIV) and has been observed in the macaque model using inactivated simian immunodeficiency virus (SIV).
Mark Robinson, Hassall, M, Stott James, Quartey-Papafio, R, Martin Cranage, Cranage, M, Page Mark, James Stott, Robinson Mark, Mark Hassall, Mark Page, Robinson, M, Quartey-Papafio Ruby, Page, M, Neil Almond, Hassall Mark, Almond, N, Almond Neil, Ruby Quartey-Papafio, Cranage Martin, Stott, J   +20 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Vaccination reduces the viral load and the risk of transmission of Jembrana disease virus in Bali cattle [PDF]

, 2009
The efficacy of a tissue-derived vaccine, which is currently used in Indonesia to control the spread of Jembrana disease in Bali cattle, was determined by quantifying the viral load in plasma following experimental infection with Jembrana disease virus ...
Wilcox, G.E., Ditcham, W.G.F., Lewis, Joshua R., Wilcox, Graham E., Desport, Moira, Hartaningsih, N., Desport, M., Dobson, Robert J., Ditcham, William G.F., Lewis, J.R., Dobson, R.J., Hartaningsih, Nining   +11 more
core   +2 more sources

Antibody-Dependent Enhancement: ″Evil″ Antibodies Favorable for Viral Infections [PDF]

, 2022
The pandemics caused by emerging viruses such as severe acute respiratory syndrome coronavirus 2 result in severe disruptions to public health. Vaccines and antibody drugs play essential roles in the control and prevention of emerging infectious diseases.
Zhang, Xin, Yuan, Mengqi, Hua-Ji Qiu, Xiaoke Yang, Xin Zhang, Xiangyu Guan, Jingwen Dai, Zhang, Kehui, Dai, Jingwen, Kehui Zhang, Qiu, Hua-Ji, Yang, Xiaoke, Guan, Xiangyu, Xiaotian Zhao, Zhao, Xiaotian, Yongfeng Li, Li, Yongfeng, Mengqi Yuan   +17 more
core   +1 more source

A high-throughput screening assay to identify inhibitory antibodies targeting alphavirus release

Virology Journal, 2022
Background Several studies have demonstrated neutralizing antibodies to be highly effective against alphavirus infection in animal models, both prophylactically and remedially.
Anushka Ramjag, Sergej Cutrone, Kai Lu, Christine Crasto, Jing Jin, Sonia Bakkour, Christine V. F. Carrington, Graham Simmons   +7 more
doaj   +1 more source

Post-Immune Antibodies in HIV-1 Infection in the Context of Vaccine Development: A Variety of Biological Functions and Catalytic Activities

Vaccines, 2022
Unlike many other viruses, HIV-1 is highly variable. The structure of the viral envelope changes as the infection progresses and is one of the biggest obstacles in developing an HIV-1 vaccine.
Anna Timofeeva, Sergey Sedykh, Georgy Nevinsky   +2 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source