Understanding the interplay between HIV-1 diversity, humoral immune responses and viral fitness [PDF]
, 2014 Includes bibliographical references.HIV-1 antibody dependent cell cytotoxicity (ADCC) and neutralizing antibody (nAb) responses are both thought to be important responses to elicit through vaccination.
Bandawe, Gama Petulo
core
Медицинская иммунология, 2014 A panel of monoclonal antibodies (MAbs) against VP35, VP40 and NP viral proteins of Marburg and Ebola viruses, as well as recombinant VP35, VP40 and NP proteins were generated and tested for their capacity to specific immune reactions.
E. I. Kazachinskaia +6 more
doaj +1 more source
Application of I131 to Determination of Viral Antibodies
Experimental Biology and Medicine, 1955 SummaryExperiments are described in which preparations of yellow fever virus, Bwamba fever virus and influenza virus were allowed to react with corresponding antisera labeled with radioactive iodine (I131). No significant differences were observed in the activity of the sediments obtained with the first 2 virus systems from those of appropriate ...
D H, CLARKE, F L, BLACK
openaire +2 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Parainfluenza virus 5 genomes are located in viral cytoplasmic bodies whilst the virus dismantles the interferon-induced antiviral state of cells [PDF]
, 2009 This work was supported by the Wellcome Trust.Although the replication cycle of parainfluenza virus type 5 (PIV5) is initially severely impaired in cells in an interferon (IFN)-induced antiviral state, the virus still targets STAT1 for degradation.
Carlos, T S +4 more
core +1 more source
Viruses, 2012 The immune response against some viral pathogens, in particular those causing chronic infections, is often ineffective notwithstanding a robust humoral neutralizing response.
Roberto Burioni +8 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Protection against myxomatosis and rabbit viral hemorrhagic disease with recombinant myxoma viruses expressing rabbit hemorrhagic disease virus capsid protein [PDF]
, 1996 Two myxoma virus-rabbit hemorrhagic disease virus (RHDV) recombinant viruses were constructed with the SG33 strain of myxoma virus to protect rabbits against myxomatosis and rabbit viral hemorrhagic disease.
Milon, Alain +13 more
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The Effects of Pre-Existing Antibodies on Live-Attenuated Viral Vaccines [PDF]
, 2020 Live-attenuated vaccines (LAVs) have achieved remarkable successes in controlling virus spread, as well as for other applications such as cancer immunotherapy.
Darren Z. L. Mok, Kuan Rong Chan
core +1 more source
Understudied Factors Influencing Fc-Mediated Immune Responses against Viral Infections
Vaccines, 2019 Antibodies play a crucial role in host defense against viruses, both by preventing infection and by controlling viral replication. Besides their capacity to neutralize viruses, antibodies also exert their antiviral effects by crystallizable fragment (Fc)-
Sai Priya Anand, Andrés Finzi
doaj +1 more source