Results 51 to 60 of about 494,114 (145)

Defining neutralization and allostery by antibodies against COVID-19 variants

Nature Communications, 2023
The changing landscape of SARS-CoV-2 Spike protein is linked to the emergence of variants, immune-escape and reduced efficacy of the existing repertoire of anti-viral antibodies.
Nikhil Kumar Tulsian, Raghuvamsi Venkata Palur, Xinlei Qian, Yue Gu, Bhuvaneshwari D/O Shunmuganathan, Firdaus Samsudin, Yee Hwa Wong, Jianqing Lin, Kiren Purushotorman, Mary McQueen Kozma, Bei Wang, Julien Lescar, Cheng-I Wang, Ravindra Kumar Gupta, Peter John Bond, Paul Anthony MacAry   +15 more
doaj   +1 more source

Diagnosis and management of chronic viral hepatitis: Antigens, antibodies and viral genomes [PDF]

Best Practice & Research Clinical Gastroenterology, 2008
Virological tools, including serological and molecular tools, are needed to diagnose chronic hepatitis B and C infections. They may also be useful to establish their prognosis, but they have found their principal application in guiding treatment decisions and assessing the virological responses to therapy.
Chevaliez, Stéphane, Pawlotsky, Jean-Michel   +1 more
openaire   +3 more sources

Beyond bNAbs: Uses, Risks, and Opportunities for Therapeutic Application of Non-Neutralising Antibodies in Viral Infection

Antibodies
The vast majority of antibodies generated against a virus will be non-neutralising. However, this does not denote an absence of protective capacity.
Kahlio Mader, Lynn B. Dustin
doaj   +1 more source

Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape pathways

iScience, 2022
Summary: The rapid spread of SARS-CoV-2 variants poses a constant threat of escape from monoclonal antibody and vaccine countermeasures. Mutations in the ACE2 receptor binding site on the surface S protein have been shown to disrupt antibody binding and ...
Fangzhu Zhao, Celina Keating, Gabriel Ozorowski, Namir Shaabani, Irene M. Francino-Urdaniz, Shawn Barman, Oliver Limbo, Alison Burns, Panpan Zhou, Michael J. Ricciardi, Jordan Woehl, Quoc Tran, Hannah L. Turner, Linghang Peng, Deli Huang, David Nemazee, Raiees Andrabi, Devin Sok, John R. Teijaro, Timothy A. Whitehead, Andrew B. Ward, Dennis R. Burton, Joseph G. Jardine   +22 more
doaj  

The effect of maternal immunity on the equine gammaherpesvirus type 2 and 5 viral load and antibody response.

PLoS ONE, 2019
Two types of gammaherpesviruses (γEHV) are known to infect horses, EHV-2 and EHV-5. Foals become infected early in life, probably via the upper respiratory tract, despite maternal antibodies.
Lilja Thorsteinsdóttir, Sigríður Jónsdóttir, Sara Björk Stefánsdóttir, Valgerður Andrésdóttir, Bettina Wagner, Eliane Marti, Sigurbjörg Torsteinsdóttir, Vilhjálmur Svansson   +7 more
doaj   +1 more source

Molecular and serological evidence of chikungunya virus among dengue suspected patients in Sri Lanka

Journal of Infection and Public Health
Background: Chikungunya virus (CHIKV), transmitted by Aedes mosquitoes, causes significant morbidity characterized by acute febrile illness to chronic and permanent disability in some patients.
Mya Myat Ngwe Tun, Maurine Mumo Mutua, Shingo Inoue, Yuki Takamatsu, Satoshi Kaneko, Takeshi Urano, Rohitha Muthugala, Lakkumar Fernando, Menaka Hapugoda, YINS Gunawardene, Kouichi Morita   +10 more
doaj  

Potent SARS-CoV-2 neutralizing antibodies with therapeutic effects in two animal models

iScience, 2022
Summary: The use of therapeutic neutralizing antibodies against SARS-CoV-2 infection has been highly effective. However, there remain few practical antibodies against viruses that are acquiring mutations.
Masaru Takeshita, Hidehiro Fukuyama, Katsuhiko Kamada, Takehisa Matsumoto, Chieko Makino-Okamura, Tomomi Uchikubo-Kamo, Yuri Tomabechi, Kazuharu Hanada, Saya Moriyama, Yoshimasa Takahashi, Hirohito Ishigaki, Misako Nakayama, Cong Thanh Nguyen, Yoshinori Kitagawa, Yasushi Itoh, Masaki Imai, Tadashi Maemura, Yuri Furusawa, Hiroshi Ueki, Kiyoko Iwatsuki-Horimoto, Mutsumi Ito, Seiya Yamayoshi, Yoshihiro Kawaoka, Mikako Shirouzu, Makoto Ishii, Hideyuki Saya, Yasushi Kondo, Yuko Kaneko, Katsuya Suzuki, Koichi Fukunaga, Tsutomu Takeuchi   +30 more
doaj  

Antibody-Dependent Enhancement of Viral Infections [PDF]

, 2020
Antiviral antibodies constitute an important component of the host immune response against viral infections and serve to neutralize and reduce infectivity of the virus. However, these antibodies, intended to protect the host, may sometimes prove beneficial to the virus, by facilitating viral entry and replication in the target cell.
openaire   +2 more sources

ASSESSMENT OF THE ACTUAL AND POTENTIAL EPIDEMIOLOGYCAL SITUATION OF THE VIRAL HEPATITIS C AND B BASED BY LABORATORY DATA IN THE “DOCTOR PARAMONOV’S CLINIC” IN SARATOV CITY AND SARATOV REGION

Паёми Сино, 2017
Objective: Study of the prevalence of the viral hepatitis C and viral hepatitis B in the territory of Saratov City and Saratov Region, analysis of the revealed cases and discussion of laboratory diagnostics issues.
V.V. NIKITINA, V.A. PARAMONOV, G.P. GLADILIN, I.L. IVANENKO   +3 more
doaj   +1 more source

The Role of Antibody and Complement in the Control of Viral Infections.

Journal of Investigative Dermatology, 1984
Host defense against viral infection is extremely complex and includes both humoral and cellular immune mechanisms. This contribution examines the mechanisms by which antibody (Ab) and the complement (C) system, major constituents of the humoral immune system, inactivate viruses and block viral maturation in virus-infected cells in vitro.
Glen R. Nemerow, Neil R. Cooper
openaire   +3 more sources