Results 61 to 70 of about 494,114 (145)

Developing recombinant antibodies by phage display technology to neutralize viral infectious diseases

SLAS Discovery
The use of recombinant antibodies developed through phage display technology offers a promising approach for combating viral infectious diseases. By specifically targeting antigens on viral surfaces, these antibodies have the potential to reduce the ...
Mujahed I. Mustafa, Ahmed Mohammed
doaj  

Bat humoral immunity and its role in viral pathogenesis, transmission, and zoonosis

Frontiers in Immunology
Bats harbor viruses that can cause severe disease and death in humans including filoviruses (e.g., Ebola virus), henipaviruses (e.g., Hendra virus), and coronaviruses (e.g., SARS-CoV).
Anne A. Roffler, Daniel P. Maurer, Tamika J. Lunn, Tarja Sironen, Tarja Sironen, Kristian M. Forbes, Aaron G. Schmidt, Aaron G. Schmidt   +7 more
doaj   +1 more source

Antibody and complement-dependent viral neutralization [PDF]

Springer Seminars in Immunopathology, 1979
Raymond M. Welsh, Neil R. Cooper
openaire   +3 more sources

The molecular reach of antibodies crucially underpins their viral neutralisation capacity

Nature Communications
Key functions of antibodies, such as viral neutralisation, depend on high-affinity binding. However, viral neutralisation poorly correlates with antigen affinity for reasons that have been unclear. Here, we use a new mechanistic model of bivalent binding
Anna Huhn, Daniel Nissley, Daniel B. Wilson, Mikhail A. Kutuzov, Robert Donat, Tiong Kit Tan, Ying Zhang, Michael I. Barton, Chang Liu, Wanwisa Dejnirattisai, Piyada Supasa, Juthathip Mongkolsapaya, Alain Townsend, William James, Gavin Screaton, P. Anton van der Merwe, Charlotte M. Deane, Samuel A. Isaacson, Omer Dushek   +18 more
doaj   +1 more source

Longitudinal analysis of acute and convalescent B cell responses in a human primary dengue serotype 2 infection modelResearch in context

EBioMedicine, 2019
Background: Acute viral infections induce a rapid and transient increase in antibody-secreting plasmablasts. At convalescence, memory B cells (MBC) and long-lived plasma cells (LLPC) are responsible for long-term humoral immunity.
Usha K. Nivarthi, Huy A. Tu, Matthew J. Delacruz, Jesica Swanstrom, Bhumi Patel, Anna P. Durbin, Stephen S. Whitehead, Kristen K. Pierce, Beth D. Kirkpatrick, Ralph S. Baric, Ngan Nguyen, Daniel E. Emerling, Aravinda M. de Silva, Sean A. Diehl   +13 more
doaj  

Antibody control and immunopathogenesis of viral infection

, 2018
Across the animal kingdom, multivalency discriminates antibodies from all other immunoglobulin superfamily members. The evolutionary forces conserving multivalency above any other structural hallmark of antibodies remain, however, ill-defined. Here we have used antibody engineering techniques to investigate mechanisms of protection of neutralizing and ...
openaire   +3 more sources

Development of a novel hybrid alphavirus-SARS-CoV-2 particle for rapid in vitro screening and quantification of neutralization antibodies, viral variants, and antiviral drugs

, 2020
Hetrick B, He S, Chilin LD, Dabbagh D, Alem F, Narayanan A, Luchini A, Li T, Liu X, Copeland J, Pak A, Cunningham T, Liotta L, Petricoin EF, Andalibi A, Wu Y.   +15 more
europepmc   +1 more source

Anti-pA137R antibodies exacerbate the pathogenicity of African swine fever virus in pigs. [PDF]

J Virol
Zhai H, Gao Y, Zhu Y, Hou Q, Wan N, Wang T, Li S, Zhao D, Qiu H-J, Li Y.   +9 more
europepmc   +1 more source

Research Progress on the Application of Neutralizing Nanobodies in the Prevention and Treatment of Viral Infections. [PDF]

Microorganisms
Duan Q, Ai T, Ma Y, Li R, Jin H, Chen X, Zhang R, Bao K, Chen Q.   +8 more
europepmc   +1 more source

Future of bNAbs in HIV Treatment. [PDF]

Curr HIV/AIDS Rep
Tebas P.
europepmc   +1 more source