Results 211 to 220 of about 602,416 (352)

A 3D Biofabricated Disease Model Mimicking the Brain Extracellular Matrix Suitable to Characterize Intrinsic Neuronal Network Alterations in the Presence of a Breast Tumor Disseminated to the Brain

Advanced Functional Materials, EarlyView.
A 3D disease model is developed using customized hyaluronic‐acid‐based hydrogels supplemented with extracellular matrix (ECM) proteins resembling brain ECM properties. Neurons, astrocytes, and tumor cells are used to mimic the native brain surrounding.
Esra Türker, Mateo S. Andrade Mier, Jessica Faber, Mike Friedrich, Zan Lamberger, Jeannette Weigelt, Christian Stigloher, Nicoletta Murenu, Natascha Schaefer, Jörg Tessmar, Gregor Lang, Silvia Budday, Katrin G. Heinze, Antje Appelt‐Menzel, Pamela L. Strissel, Reiner Strick, Carmen Villmann   +16 more
wiley   +1 more source

Targeting uPARAP with an Antibody-Drug Conjugate Exhibits Efficacy against Mesothelioma and Synergizes with Cisplatin. [PDF]

Cancer Res Commun
Çakılkaya P, Egeland Larsen IM, Jiang Q, Sandal Nørregaard K, Gårdsvoll H, Zhang J, Jürgensen HJ, Hansen Blomquist M, Martinez Perlado A, Krigslund O, Santoni-Rugiu E, Engelholm LH, Hassan R, Behrendt N.   +13 more
europepmc   +1 more source

Table S1 from Broad-Spectrum Efficacy of CEACAM6-Targeted Antibody–Drug Conjugate with BET Protein Degrader in Colorectal, Lung, and Breast Cancer Mouse Models

Hiroyuki Kogai, Shuntaro Tsukamoto, M Koga, Masayuki Miyano, Tsuyoshi Akagi, Atsumi Yamaguchi, Kiyoshi Mori, Kunihito Gotoh, Youya Nakazawa   +8 more
openalex   +1 more source

Ice Lithography: Recent Progress Opens a New Frontier of Opportunities

Advanced Functional Materials, EarlyView.
This review focuses on recent advancements in ice lithography, including breakthroughs in compatible precursors and substrates, processes and applications, hardware, and digital methods. Moreover, it offers a roadmap to uncover innovation opportunities for ice lithography in fields such as biological, nanoengineering and microsystems, biophysics and ...
Bingdong Chang, Gwendoline A. E. Anand, Rubaiyet Haque, Dylan A. Chiaro, Mona Sharma, Andrew R. Williams, Frank Niklaus, Daryl W. Yee, Gavin M. King, Anpan Han   +9 more
wiley   +1 more source

Structural basis of nectin-4 recognition by the antibody-drug conjugate 9MW2821. [PDF]

J Biol Chem
Fang P, You M, Wen H, Cao Y, Zhou W, Zhu X, Shi L, Sun X, Li K, Li W, Wang J, Wu H, Tan X.   +12 more
europepmc   +1 more source

Supplementary Data from Preclinical Evaluation of MEDI0641, a Pyrrolobenzodiazepine-Conjugated Antibody–Drug Conjugate Targeting 5T4

, 2023
Jay Harper, CHRISTOPHER LLOYD, Nazzareno Dimasi, Dorin Toader, Rose Marwood, Leeanne Lewis, David Bannister, Jelena Jovanović, Ryan Fleming, François D’Hooge, Shenlan Mao, Allison M. Marrero, Martin Korade, Patrick Strout, Linda Xu, Cui Chen, Leslie Wetzel, Shannon Breen, Lilian van Vlerken-Ysla, Sanjoo Jalla, Marlon C. Rebelatto, Haihong Zhong, Elaine M. Hurt, Mary Jane Hinrichs, Huang Keven, Philip W. Howard, David A. Tice, Robert E. Hollingsworth, R. S. Herbst, Adeela Kamal   +29 more
openalex   +1 more source

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

CD74-Targeting Antibody-Drug Conjugate Enhances Immunosuppression of Glucocorticoid in Systemic Lupus Erythematosus. [PDF]

Int J Mol Sci
Du Q, Yao S, Huang Y, Zhang J, Sonam W, Lu X, Yang J, Cheng S, Wang R, Xu J, Ma L, Liu Y, Wu G, Zhang J, Wang X, Lu W, Ling Z, Yi C, Sun B.   +18 more
europepmc   +1 more source

Tailoring the Properties of Functional Materials With N‐Oxides

Advanced Functional Materials, EarlyView.
The properties of materials bearing N‐oxide groups are often dominated by the polar N+─O− bond. It provides hydrophilicity, selective ion‐binding, electric conductivity, or antifouling properties. Many of the underlying mechanisms have only recently been discovered, and the interest in N‐oxide materials is rapidly growing.
Timo Friedrich, Michelle Kobus, Shirin Mesgarha, Erica Moretto, Laurens Grosche, Wolfgang Maison   +5 more
wiley   +1 more source

Targeting KRAS Inhibitor-Resistant Pancreatic Cancer with an MUC1-C Antibody-Drug Conjugate. [PDF]

Clin Cancer Res
Ozawa H, Takahashi K, Motegi T, Jacobi J, Bhattarchya A, Shigeta K, Takamori S, Onishi M, Luan Z, Fukuda K, Ueno A, Kitago M, Kawakubo H, Kitagawa Y, Keith D, Muschler J, Sears RC, Long MD, Mancias JD, Aguirre AJ, Kufe D.   +20 more
europepmc   +1 more source