Results 251 to 260 of about 589,804 (355)

Engineering Topographical Cues to Enhance Neural Regeneration in Spinal Cord Injury: Overcoming Challenges and Advancing Therapies

Advanced Functional Materials, EarlyView.
Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu, Fenghui Wang, Joshua Stein, Siqiao Wang, Pengfei Jiang, Letao Yang, Liming Cheng, Ki‐Bum Lee   +7 more
wiley   +1 more source

Safety of unconventional antibody-drug conjugate L-DOS47 in a phase I/II monotherapy study targeting advanced NSCLC. [PDF]

Front Oncol
Ramlau R, Kowalski DM, Szczęsna A, Szczylik C, Ou Y, Köbel M, Siegers GM, Gaspar KJ, Lee B, Roszkowski-Sliz K.   +9 more
europepmc   +1 more source

Synergistic Osteogenesis After Co‐Administration of cmRNAs Encoding BMP‐2 and BMP‐7 Utilizing a Transcript‐Activated Matrix

Advanced Functional Materials, EarlyView.
This study demonstrates that the dual delivery of BMP‐2/‐7 coding cmRNAs for bone healing is demonstrated as feasible, safe, and highly osteogenic. Compared to single BMP‐2 or BMP‐7 cmRNAs, the combination enhances the production of both mineral and organic components of the extracellular matrix when delivered using a collagen‐HA scaffold, supporting ...
Claudia Del Toro Runzer, Joanna M. Sadowska, Nadia Roumans, Christian Plank, Christopher H. Evans, Fergal J. O'Brien, Martijn van Griensven, Elizabeth R. Balmayor   +7 more
wiley   +1 more source

First in Human Study with GSK2857916, an Antibody Drug Conjugated to Microtubule-Disrupting Agent Directed Against B-Cell Maturation Antigen (BCMA) in Patients with Relapsed/Refractory Multiple Myeloma (MM): Results from Study BMA117159 Part 1 Dose Escalation

, 2016
Adam D. Cohen, Rakesh Popat, Suzanne Trudel, Paul G. Richardson, Ed N. Libby, Nikoletta Lendvai, Larry D. Anderson, Heather J. Sutherland, Stephen DeWall, Catherine Ellis, Zangdong He, Jolly Mazumdar, Catherine Wang, Joanna Opalinska, Peter M. Voorhees   +14 more
openalex   +1 more source

Antibody–Drug Conjugates as Cancer Therapeutics: Past, Present, and Future [PDF]

, 2017
Heather Vezina, Monette Cotreau, Tae Hyung Han, Manish Gupta   +3 more
openalex   +1 more source

An antibody-drug conjugate targeting VpreB1 for the treatment of B-cell acute lymphoblastic leukemia. [PDF]

Blood Neoplasia
Gordon PM, Williams RL, Ostergaard J, Lee KC, Bui HN, Muretta JM, Wilson BS, Beder T, Baldus CD, Lambert L, Deonovic BE, Singleton T, Tasian SK, Winter SS.   +13 more
europepmc   +1 more source

Aptamer Functionalized Hydrogel Dressings for Post‐Surgery Tumor Recurrence Inhibition and Tissue Reconstruction

Advanced Functional Materials, EarlyView.
Post‐surgical tumor therapy struggles with recurrence and inefficient healing. Anti‐tumor DNA aptamer functionalized gelatin hydrogels, Apt‐GelMA, simultaneously address both issues by suppressing tumor regrowth via targeted tumor cell inhibition and enhancing wound healing through improved cell adhesion and migration. Their biocompatibility, stability,
Tianyue Li, Xin‐Yi Qian, Zi‐Yuan Li, Hao‐Wen Li, Poh‐Ching Tan, Chenghuizi Hu, Jiajun Jin, Shuang‐Bai Zhou, Qing‐Feng Li, He Tian, Junji Zhang, Itamar Willner   +11 more
wiley   +1 more source

Antibody drug conjugates: lessons from 20 years of clinical experience

, 2016
Anthony W. Tolcher
openalex   +1 more source

KK2845, a PBD dimer-containing antibody-drug conjugate targeting TIM-3-expressing AML. [PDF]

Leukemia
Zou J, Kinosada H, Takayanagi SI, Ishii T, Amano T, Nihira K, Kanie S, Adachi M, Tahara H, Sakoda T, Kikushige Y, Akashi K, Satou H.   +12 more
europepmc   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source