Results 261 to 270 of about 602,416 (352)

Supplementary Table S3 from Safety and Tolerability of a Novel Anti-HER2 Antibody–Drug Conjugate (PF-06804103) in Patients with HER2-Expressing Solid Tumors: A Phase 1 Dose-Escalation Study [PDF]

Funda Meric-Bernstam, Emiliano Calvo, Keun Seok Lee, Victor Moreno, Yeon Hee Park, Sun Young Rha, Pavani Chalasani, Wei Zhong, Li Zhou, Steven Pirie-Shepherd, Abraham C.F. Leung, Giuseppe Curigliano   +11 more
openalex   +1 more source

Processing of mitochondrial precursor proteins [PDF]

, 1984
Neupert, Walter, Schmidt, Bernd
core  

Laser‐Microscribed Glass Enables Surface‐Microfluidics‐Facilitated, Affordable, Rapid Cancer Diagnosis

Advanced Functional Materials, EarlyView.
A transparent, laser‐microscribed glass platform enables cancer diagnosis within 1 h—much faster than histology, which takes days, and free from the chemical or contrast risks of MRI or CT scans. The antibody‐functionalized rough glass surface captures viable cancer cells directly from suspension, allowing instant optical readout and offering a rapid ...
Anish Pal, Snehasis Mishra, Arani Mukhopadhyay, Ilias Papailias, Atique U. Ahmed, Constantine M. Megaridis   +5 more
wiley   +1 more source

Identification of a Novel Linker Enabling the Bioconjugation of a Cyclic Dinucleotide for the STING Antibody-Drug Conjugate TAK-500. [PDF]

Bioconjug Chem
Lee HM, Abdul-Hadi K, Appleman VA, Cardin D, Dong L, England D, Ganno ML, Gershman R, Gigstad K, Gulavita N, Hu Z, Huang J, Huang SC, Lok D, Ma L, Malley J, Mizutani M, Molchanova N, Piatkov KI, Rice E, Shi Z, Vyskocil S, Wang J, Xu H, Xu T, Zhang DM, Zhang J, Abu-Yousif AO.   +27 more
europepmc   +1 more source

PRELIVE: A Framework for Predicting Lipid Nanoparticles In Vivo Efficacy and Reducing Reliance on Animal Testing

Advanced Functional Materials, EarlyView.
PREdicting LNP In Vivo Efficacy (PRELIVE) framework enables the prediction of lipid nanoparticle (LNPs) organ‐specific delivery through dual modeling approaches. Composition‐based models using formulation parameters and protein corona‐based models using biological fingerprints both achieve high predictive accuracy across multiple organs.
Belal I. Hanafy, Chuan‐En Lu, Kai Liu, Audrey Gallud   +3 more
wiley   +1 more source

Hybrid Microdiscs for Magnetically Induced Non‐Cytotoxic Thermal Actuation and Programmable Biomolecule Delivery

Advanced Functional Materials, EarlyView.
Hybrid magnetic microdiscs with customizable size and composition are engineered through refined photolithography and LbL assembly. Embedded Fe3O4 nanoparticles enable localized, non‐cytotoxic heating, while protein cargos can be incorporated in tunable quantities.
Daniela Iglesias‐Rojas, Danny Villanueva, Jon Mentxaka‐Salgado, Nerea Lete, Ane Olazagoitia‐Garmendia, Eduardo Fernández, Iñaki Orue, Alfredo García‐Arribas, Maria Luisa Fdez‐Gubieda, Ainara Castellanos‐Rubio, Robert Morel, Bernard Dieny, Maite Insausti, Idoia Castellanos‐Rubio   +13 more
wiley   +1 more source

Overcoming immunotherapy resistance in bladder cancer with a novel antibody-drug conjugate RC48. [PDF]

J Immunother Cancer
Xiao J, Liu J, Zhang C, Liu Z, Nie Z, Yi Z, Gao X, Liang H, Huang J, Cai Z, Yan L, Wu B, Liu Z, Chen J, Zu X, Hu J.   +15 more
europepmc   +1 more source

An Ultrafast Self‐Gelling Versatile Hydrogel for Rapid Infected Burn Wound Repair in Military Medicine

Advanced Functional Materials, EarlyView.
A self‐gelling PG@PAC (POD/Gel‐CDH@PA/CHX) powder is developed for infected burn care in austere settings. Upon contact with wound exudate, it instantly forms an adhesive hydrogel, providing simultaneous hemostasis, broad‐spectrum antibacterial activity, reactive oxygen species scavenging, and immunomodulation. In a murine model of S.
Liping Zhang, Zhangrui Wu, Xiansheng Zhao, Geng Wang, Quyang Yang, Minxia zhang, Xiaowei Wang, Xiujun Cheng, Changyue Wu, Dan Wu, Yutian Yang, Canbin Dong, Tao Zhang, Weiqiang Tan, Ningwen Zhu   +14 more
wiley   +1 more source

The Impact of Conjugation Mode and Site on Tubulysin Antibody-Drug-Conjugate Efficacy and Stability. [PDF]

ChemistryOpen
Yamazoe S, Cheng Q, Kotapati S, Rangan VS, Sung MC, Deshpande M, Jashnani A, Qiang C, Smith MJ, Pan C, Dollinger G, Rajpal A, Strop P, Rao C.   +13 more
europepmc   +1 more source

Injectable Dual‐Network Hydrogel System for Osteochondral Repair Combining Immunomodulation, Mechanical Adaptability, and Enhanced Tissue Integration

Advanced Functional Materials, EarlyView.
A UV‐triggered injectable dual‐network hydrogel is reported as the first application of bletilla striata polysaccharide (BSP) in osteochondral repair. By integrating methacrylamide‐modified BSP and nitrobenzaldehyde‐functionalized hyaluronic acid, the system achieves immunomodulation, mechanical reinforcement, and dynamic tissue adhesion, thereby ...
Jiaming Cui, Feifei Zhou, Yuan Luo, Tao Ouyang, Huiwu Zhang, Songmiao Cheng, Qiang Li, Xu Jiang, Yingying Yu, Yicheng Wang, Hong Ming   +10 more
wiley   +1 more source