Results 271 to 280 of about 602,416 (352)

Glioblastoma resistance to EGFR antibody-drug conjugate is driven by transcriptional reprogramming and TEK-induced EGFR suppression. [PDF]

J Transl Med
Blomquist MR, Noviello TMR, Sereduk C, Grief D, Caruso FP, Sharma R, Garcia-Mansfield K, Pirrotte P, Kloss J, D'Angelo F, Marin BM, Porath K, Jain S, Rabichow B, Ensign SPF, Iavarone A, Paladino A, Sarkaria JN, Loftus JC, Ceccarelli M, Tran NL.   +20 more
europepmc   +1 more source

Drug‐Free Thrombolysis Mediated by Physically Activated Micro/Nanoparticles

Advanced Functional Materials, EarlyView.
Overview of particle‐mediated thrombolytic effects (thermal, mechanical, and chemical) and their activating physical stimuli (light, ultrasound, and magnetic field) in drug‐free thrombolysis. ABSTRACT Thrombus‐associated disorders rank among the world's leading causes of death, with ischemic heart disease and stroke as the main contributors.
Pierre Sarfati, Yoann Lalatonne, Cédric Chauvierre   +2 more
wiley   +1 more source

Phase I/II Study of AXL-Specific Antibody-Drug Conjugate Enapotamab Vedotin in Patients with Advanced Solid Tumors. [PDF]

Cancer Res Commun
Rohrberg KS, Lopez JS, Milhem MM, Blank CU, Reijers I, Thistlethwaite F, Plummer R, Piha-Paul SA, Jänne PA, Shum E, Shaw HM, Debruyne PR, Lao C, Baurain JF, Choe JH, Gort E, Zhao Y, Jerusalem G, Schöffski P, Chen AW, Cohen EA, Mankowski WC, Roshkovan L, Katz SI, Kontos D, Brady LK, Qutaish M, Castro PG, Pencheva N, Bajaj G, Fu Y, Windfeld K, Reiter P, Jure-Kunkel M, Higgs BW, Amiri KI, Ahmadi T, Forssmann U, Ramalingam SS, Vergote I.   +39 more
europepmc   +1 more source

Self‐Feeding of Engineered Tissues via Controlled Glucose Release Facilitates Survival and Vascularization of Living Implants

Advanced Functional Materials, EarlyView.
ABSTRACT Engineering living matter has great clinical potential to deliver functional replacement organs. However, clinical translation remains hampered by the current inability to maintain viability of clinically relevant‐sized constructs. During the pre‐vascular phase, implants rely on nutrient diffusion for survival, which is insufficient at ...
Melvin Gurian, Iris E. Allijn, Laura Veenendaal, Nicole Bassous, Su Ryon Shin, Jeroen Leijten   +5 more
wiley   +1 more source

A Novel FGFR3-Targeting Antibody-Drug Conjugate Induces Tumor Cell Apoptosis through the cGAS-STING Pathway in Bladder Cancer. [PDF]

Adv Sci (Weinh)
Cui S, Luo X, Fan G, Jiang J, Wang Y, Yang E, Ma J, Zhang Z, Wang Y, Wang J, Wang D, Wang H, Cheng L, Tian J, Dong Z, Liu Y, Wang Z.   +16 more
europepmc   +1 more source

Supplementary Figure S1 from Design and Evaluation of ZD06519, a Novel Camptothecin Payload for Antibody Drug Conjugates

Mark E. Petersen, Michael G. Brant, Manuel Lasalle, Samir Das, Renee Duan, Jodi Wong, Tong Ding, Kaylee J. Wu, Dayananda Siddappa, Chen Fang, Wen Zhang, Alex M. L. Wu, Truman Hirkala-Schaefer, Graham A. E. Garnett, Vincent Fung, Luying Yang, Andrea Hernández Rojas, Samuel O. Lawn, Stuart D. Barnscher, Jamie R. Rich, Raffaele Colombo   +20 more
openalex   +1 more source

Recent Technological and Intellectual Property Trends in Antibody–Drug Conjugate Research [PDF]

Youngbo Choi, Y. Choi, Surin Hong
openalex   +1 more source

Gold Nanoclusters as Dual Agents for Engineering Tumor Vascular Leakiness and Performing Photothermal Therapy

Advanced Functional Materials, EarlyView.
Many cancer nanotherapeutics, while potent, suffer from the inability to escape from the tumor vasculature, especially in the absence of endothelial permeability. In this work, ultrasmall gold nanoclusters could engineer nanomaterials induced endothelial leakiness (NanoEL) and harness strong NIR induced photothermal characteristics to suppress tumor ...
Nengyi Ni, Kuoran Xing, Bihan Zhang, Baoteng Wang, Yinglu Chen, Jianping Xie, Xiao Sun, Jinping Wang, David Tai Leong   +8 more
wiley   +1 more source

Adverse events induced by the subcutaneous HER2-targeted antibody-drug conjugate JSKN033 in a male patient with breast cancer: A case report. [PDF]

Oncol Lett
Yang R, Zhang J, Wang Y.
europepmc   +1 more source

Supplementary Table 3 from Selective STING Activation in Intratumoral Myeloid Cells via CCR2-Directed Antibody–Drug Conjugate TAK-500

Vicky A. Appleman, Atsushi Matsuda, Michelle L. Ganno, Dong Mei Zhang, Emily Rosentrater, Angel E. Maldonado Lopez, Angelo Porciuncula, Tiquella Hatten, Camilla L. Christensen, Samantha A. Merrigan, Hong Myung Lee, Min Young Lee, Charlotte I. Wang, Linlin Dong, Jian Huang, Natasha Iartchouk, Jianing Wang, He Xu, Tomoki Yoneyama, Konstantin I. Piatkov, Satyajeet Haridas, Carole E. Harbison, Richard C. Gregory, Alexander Parent, Neil Lineberry, Chris Arendt, Kurt A. Schalper, Adnan O. Abu‐Yousif   +27 more
openalex   +1 more source