Results 331 to 340 of about 589,804 (355)

A phase I dose escalation study evaluating the safety and tolerability of a novel anti-HER2 antibody-drug conjugate (PF-06804103) in patients with HER2-positive solid tumors.

, 2020
1039Background: PF-06804103 is an anti-HER2 immunoglobulin G1 antibody-drug conjugate (ADC), comprising an anti-HER2 monoclonal antibody conjugated with a cleavable linker to the cytotoxic agent Au...
F. Meric-Bernstam, E. Calvo, V. Moreno, H. Chung, Yeon-Hee Park, Y. Bang, L. Rosen, M. Mita, I. Garrido-Laguna, A. Leung, H. Dube, W. Zhong, Xiaoying Chen, Rula Dawaher, G. Curigliano   +14 more
semanticscholar   +1 more source

First-in-human phase I study of ALT-P7, a HER2-targeting antibody-drug conjugate in patients with HER2-positive advanced breast cancer.

, 2020
3551Background: ALT-P7 is an antibody-drug conjugate, in which two molecules of monomethyl auristatin E (MMAE) are site-specifically conjugated to a cysteine-containing peptide motif of trastuzumab...
Yeon-Hee Park, H. Ahn, Ji-yeon Kim, J. Ahn, Y. Im, Seol-Hee Kim, Sunbae Lee, Hye-Shin Chung, Soon-Jae Park   +8 more
semanticscholar   +1 more source

Click Nucleophilic Conjugate Additions to Activated Alkynes: Exploring Thiol-yne, Amino-yne, and Hydroxyl-yne Reactions from (Bio)Organic to Polymer Chemistry

Chemical Reviews, 2021
Joshua C Worch, Matthew J Price, Andrew Dove   +2 more
exaly  

The antibody-drug conjugate landscape.

Nature reviews. Drug discovery
Patrick M. Flynn, Smruthi Suryaprakash, Daniel Grossman, Val Panier, John Wu   +4 more
semanticscholar   +1 more source

Photoinduced chemomimetic biocatalysis for enantioselective intermolecular radical conjugate addition

Nature Catalysis, 2022
Xiaoqiang Huang, Guangde Jiang, Wesley Harrison   +2 more
exaly  

Multifunctional biocatalyst for conjugate reduction and reductive amination

Nature, 2022
Thomas W Thorpe, James R Marshall, Vanessa Harawa   +2 more
exaly  

Phase 1 study of the anti-BCMA antibody-drug conjugate AMG 224 in patients with relapsed/refractory multiple myeloma

Leukemia, 2020
Hans C. Lee, N. Raje, O. Landgren, V. Upreti, Jin Wang, A. Avilion, Xuguang Hu, E. Rasmussen, G. Ngarmchamnanrith, H. Fujii, A. Spencer   +10 more
semanticscholar   +1 more source

Hodgkin lymphoma: A review and update on recent progress

Ca-A Cancer Journal for Clinicians, 2018
Satish P Shanbhag, Richard F Ambinder
exaly  

Application of Nanotechnology in Cancer Therapy and Imaging

Ca-A Cancer Journal for Clinicians, 2008
Dong M Shin
exaly  

Peptide–TLR-7/8a conjugate vaccines chemically programmed for nanoparticle self-assembly enhance CD8 T-cell immunity to tumor antigens

Nature Biotechnology, 2020
Geoffrey M Lynn, Christine Sedlik, Faezzah Baharom   +2 more
exaly