Results 201 to 210 of about 211,312 (294)

Immunological Biomarkers in Glioblastoma: Targeting T and NK Cells for Enhanced Diagnosis and Prognosis. [PDF]

Biologics
Akbari AM, Bourbour S, Seyedmehdi MS, Shiari S, Rustamzadeh A, Seif F, Farivar S.   +6 more
europepmc   +1 more source

Cetuximab-mediated antibody-dependent cell-mediated cytotoxicity enhances anti-tumor efficacy of patient-derived natural killer cells in pancreatic cancer

EunJi Kim, Eunsung Jun, You Sun Kim, Haeyeop Kim, H. An, Seong‐Jin Kim, Seong‐Jin Kim, Bokyung Min, Song Cheol Kim, Song Cheol Kim   +9 more
openalex   +1 more source

IL‐7R‐Enriched Extracellular Vesicles From the Thymus Drive Colitis via Promoting Neutrophil Extracellular Trap Formation

Advanced Science, EarlyView.
Inflammatory bowel disease (IBD) pathogenesis remains unclear. This study reveals that thymus‐originated IL‐7R‐enriched extracellular vesicles exacerbate colitis by promoting neutrophil extracellular traps via a thymus‐gut axis, uncovering an inter‐organ communication mechanism in inflammatory bowel disease pathogenesis.
Yao Liao, Yuheng Liu, Ruibing Yang, Zifeng Zhu, Junwei Wu, Dinghao Li, Jin Su, Yingxin He, Shiqi Luo, Feiyang Cao, Haiyi Deng, Lanmengxi Yang, Ling Zhong, Peiying Peng, Xinyi Wu, Chunmei Cai, Zhen Li, Yujin Wu, Shuofeng Zhu, Jie Wei, Yi Yang, Lifu Wang   +21 more
wiley   +1 more source

Novel ADC and γδ T cell engager targeting CDH17 for the therapy of gastrointestinal cancers. [PDF]

Antib Ther
Yu M, Mu G, Chen P, Bi H, Zhou F, Zha Z, Huang S, Jiang H, Jin Y, Chen Y, Chiu ML, Zhang D.   +11 more
europepmc   +1 more source

Synthetic Toll‐Like Receptors for Control of Innate Immunity With Far‐Red Light

Advanced Science, EarlyView.
Synthetic Toll‐like receptors (TLRs) are engineered by replacing their natural sensing regions with a far‐red‐light‐responsive module from a bacterial phytochrome. These synthetic receptors enable light‐controlled regulation of immune signaling in mammalian cells.
Anna V. Leopold, Vladislav V. Verkhusha
wiley   +1 more source

Broadly neutralizing antibody-secreting CAR-T cells elicit Fc-mediated effector functions <i>in vitro</i> and suppress HIV in humanized mice. [PDF]

Front Immunol
Stylianidou Z, Gerlo S, Wejda M, Burg E, De Smet E, Noppe Y, Verschoore M, Van Cleemput J, Vandekerckhove L, Witkowski W.   +9 more
europepmc   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

Umbilical cord blood natural killer cells improve anti-GD2 antibody efficacy in neuroblastoma: from mouse to human. [PDF]

Oncoimmunology
Song M, Lan Y, Tan X, Wu L, Zhu J, Lu S, Sun F, Gao M, Huang J, Que Y, Zhang Y, Fang X, Li M, Mai Y, Wang J, Xiang T, Zhang Y.   +16 more
europepmc   +1 more source

T-cell activation enhances anti-HER2-mediated antibody-dependent cellular cytotoxicity in gastric cancer

Zirui Xue, Zhaoming Wang, Dan Liu, Bosen Li, Zhaodong Sun, Junjie Zhao, Haojie Li, Xuefei Wang, Yihong Sun   +8 more
openalex   +1 more source

UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation

Advanced Science, EarlyView.
ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro, Anna Beekmayer‐Dhillon, Qi Wen Teo, Lewis Siu, Ming Yuan Li, Kate J. Heesom, Adán Pinto‐Fernández, Sumana Sanyal   +7 more
wiley   +1 more source