Results 211 to 220 of about 230,585 (263)

Antibody-Dependent Cell-Mediated Cytotoxicity in Humans

The Journal of Immunology, 1975
Abstract Mononuclear cells from human peripheral blood are able to destroy alloantibody-coated target cells of a human lymphoblastoid line. The effector cell is a nonadherent, non-phagocytic, medium sized lymphoid cell. This cell is not detectable in early human fetuses.
Giorgio Trinchieri, Peter Bauman, Mario de Marchi, Zoltán Tökés   +3 more
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Surface properties of cells involved in antibody-dependent cytotoxicity

Cellular Immunology, 1976
Abstract Using a recently developed technique for separating cells, the two cell types that mediate the destruction of antibody coated target cells, namely K cells and macrophages, have been characterized according to a series of cell surface markers.
Ramshaw, I A, Parish, C R
openaire   +2 more sources

SELECTIVE REACTIONS IN ANTIBODY-DEPENDENT CELL-MEDIATED CYTOTOXICITY

Transplantation, 1977
Selective reactions associated with HLA specificity were sought in antibody-dependent cell-mediated cytotoxic tests against HLA-typed lymphoblastoid lines using operationally monospecific HLA sera and effector cells from healthy individuals. Precise detection of HLA specificities was disturbed by the presence of natural antibodies in HLA antiserum and ...
J, Takasugi, M, Takasugi
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Human lymphoblast cell lines: Antibody‐dependent cytotoxicity

European Journal of Immunology, 1975
AbstractFive cell lines were isolated after prolonged culture of human buffy coat leukocytes. The cells consisted for the most part of lymphoblasts morphologically similar to those produced by in vivo or in vitro stimulation of small lymphocytes by antigens or mitogens. One of the lines possessed virus‐like particles of the Epstein‐Barr type.
J C, Lefebre, A, Petitprez, D, Juy, C, Bona   +3 more
openaire   +2 more sources

Reversible blocking of antibody-dependent cell-mediated cytotoxicity

Cellular Immunology, 1977
Abstract The ability of human peripheral blood lymphocytes to kill antibody-coated Chang liver cells in antibody-dependent cell-mediated cytotoxicity (ADCC) can be blocked with aggregated IgG (agg-IgG) or by soluble immune complexes. Dissociation of aggregates of IgG or immune complexes from the cell surface, however, resulted in partial recovery of ...
K, Sugamura, J B, Smith
openaire   +2 more sources

Assessing Antibody-dependent, Cell-mediated Cytotoxicity in Cancer Cells using Antibody-Dependent Cell-Mediated Cytotoxicity Reporter Bioassay

Journal of Visualized Experiments
The method for antibody-dependent, cell-mediated cytotoxicity (ADCC) represents an important tool to assess the efficacy of therapeutic antibodies in cancer immunotherapy. Evaluating ADCC activity in cancer cells is essential for the development and optimization of antibody-based treatments.
Kelvin Kam Yew, Kuan, Ke, Zhang, Koon Hwee, Ang, Min, Thura, Wei Hui, Zheng   +4 more
openaire   +2 more sources

Bovine antibody dependent cell-mediated cytotoxicity (ADCC) effector cells

Veterinary Immunology and Immunopathology, 1987
ADCC effector cells from bovine blood were separated by centrifugation, adherence and rosetting techniques. Each enriched cell population, peripheral blood mononuclear cells (PBM), null lymphocytes, monocytes and neutrophils, was then examined for its capacity to mediate ADCC.
E L, Belden, H M, Peng
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Antibody-dependent Cell-mediated Cytotoxicity due to a “Null” Lymphoid Cell

Nature New Biology, 1973
ANTIBODY-COATED target cells may be killed by suspensions of lymphoid cells after depletion of active phagocytes1–4. Harding et al.5 and Van Boxel et al.6 also report that a non-thymus-derived lymphocyte is responsible for this antibody-dependent cell-mediated cytotoxicity in both the rat and mouse. The further observations that the cytotoxic cell acts
Greenberg, A H, Hudson, L, Shen, L, Roitt, I M   +3 more
openaire   +2 more sources

Antibody‐Dependent Cell‐Mediated Cytotoxicity in the Mouse

Scandinavian Journal of Immunology, 1974
The surface characteristics of the mouse spleen cells mediating antibody‐dependent cytotoxicity (ADCC) against antigen‐coated chicken erythrocytes have been studied by several different column fractionation methods The major effector cells in this system were shown to be surface‐adherent and could be depleted from spleen cells by passage through glass ...
H F, Pross, D E, Tracey, H, Wigzell, V, Schirrmacher   +3 more
openaire   +2 more sources

Different effector cell types in antibody-dependent cell-mediated cytotoxicity

Nature, 1975
ANTIBODY-DEPENDENT cell-mediated cytotoxicity has been demonstrated in vitro using a number of continuously cultivated cell lines1,2 and nucleated erythrocytes3 as targets. Although the biological role of this cytotoxicity is not yet clear, it represents a potentially efficient cytotoxic mechanism and considerable interest has been shown in the ...
C J, Sanderson, I A, Clark, G A, Taylor
openaire   +2 more sources