Results 101 to 110 of about 140,297 (347)

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

AI-driven innovation in antibody-drug conjugate design

Frontiers in Drug Discovery
Antibody-drug conjugates (ADCs) represent a mechanistically defined class of targeted therapeutics that combine monoclonal antibodies with cytotoxic payloads to achieve selective delivery to antigen-expressing carcinoma cells.
Heather A. Noriega, Xiang Simon Wang
doaj   +1 more source

Profiling and targeting HER2-positive breast cancer using trastuzumab emtansine. [PDF]

, 2014
PurposeThis article reviews the mechanism of action of trastuzumab emtansine (T-DM1), existing clinical data relating to its use for human growth factor receptor 2 (HER2)-positive breast cancer, potential pathways of resistance, and ongoing studies ...
Hurvitz, Sara A, Olevsky, Olga, Sadeghi, Saeed   +2 more
core   +1 more source

Antibody-Drug Conjugates in Bladder Cancer

Bladder Cancer, 2018
Urothelial carcinoma (UC) is characterized by expression of a plethora of cell surface antigens, thus offering opportunities for specific therapeutic targeting with use of antibody-drug conjugates (ADCs). ADCs are structured from two major constituents, a monoclonal antibody (mAb) against a specific target and a cytotoxic drug connected via a linker ...
Panagiotis J. Vlachostergios, Priyanka Patel, Scott T. Tagawa, Aileen Lee, Amy Hackett, Muhammad Junaid Niaz, Christopher D. Jakubowski, Naureen Rashid, Charlene Thomas   +8 more
openaire   +4 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Somatostatin subtype-2 receptor-targeted metal-based anticancer complexes [PDF]

, 2012
Conjugates of a dicarba analogue of octreotide, a potent somatostatin agonist whose receptors are overexpressed on tumor cells, with [PtCl 2(dap)] (dap = 1-(carboxylic acid)-1,2-diaminoethane) (3), [(η 6-bip)Os(4-CO 2-pico)Cl] (bip = biphenyl, pico ...
Alejandro González-Cantó, Algueró B., Anna Massaguer, Barragán F., Barragán F., Bauer W., Carlos González, Cascini G. L., Casini A., Chaplin A. B., Charvat T. T., de Jong M., Deshmukh M. V., Dirscherl G., Dolors Carrion-Salip, D’Addona D., Fischer R., Flavia Barragán, Gariepy J., Gasser G., Gianferrara T., Gossens C., Gross A., Hodson E., Hornick C. A., Hsieh H.-P., Huang C. M., Irene Gómez-Pinto, Jakupec M. A., Jakupec M. A., Janecka A., Jennerwein M., Koradi R., Kostrhunova H., Kostrhunova H., Levina A., Liu H.-K., Marchán V., Marchán V., Melacini G., Metzler-Nolte N., Mezo G., Moradell S., Moreno V., Morris R. E., Mukhopadhyay S., Novakova O., Okarvi S. M., Peacock A. F. A., Peacock A. F. A., Peacock A. F. A., Peindy N’Dongo H. W., Peter J. Sadler, Pizarro A. M., Puckett C. A., Rademaker-Lakhai J. M., Rafael de Llorens, Reubi J. C., Reubi J. C., Schaer J. C., Singh S. K., Splith K., Sun L.-C., Süss-Fink G., van Rijt S. H., van Rijt S. H., van Rijt S. H., van Rijt S. H., Vicente Marchán, Virtudes Moreno, Wang F., Wang F., Watson J. C., Wheate N. J., Wynants C., Wynants C., Zaccaro L., Zhang J., Zhang Y.   +78 more
core   +5 more sources

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Antibody Conjugation and Formulation [PDF]

, 2019
In an era where ultra-high antibody concentrations, high viscosities, low volumes, auto-injectors, and long storage requirements are already complex problems with the current unconjugated monoclonal antibodies on the market the formulation demands for ...
Alves, Nathan J.
core   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

The effects of zinc sulfate on ethyl glucuronide immunoassay urine testing [PDF]

, 2016
Published research in the Journal of Analytical Toxicology and the American Society for Clinical Pathology has confirmed that the presence of Zinc Sulfate in adulterated urine samples can influence the testing results using EMIT and ELISA immunoassay ...
Cawley, Shanna Marie
core   +1 more source