Results 131 to 140 of about 349,757 (388)

Anti-CD48/MMAE Antibody-drug Conjugate SGN-CD48A [PDF]

, 2020
National Cancer Institute
openalex   +1 more source

A comprehensive review of key factors affecting the efficacy of antibody drug conjugate.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023
A. Samantasinghar, Naina Sunildutt, Faheem Ahmed, Afaque Manzoor Soomro, A. Salih, Pratibha Parihar, F. H. Memon, K. Kim, In Suk Kang, Kyung-Hyun Choi   +9 more
semanticscholar   +1 more source

Native size-exclusion chromatography-mass spectrometry: suitability for antibody–drug conjugate drug-to-antibody ratio quantitation across a range of chemotypes and drug-loading levels

mAbs, 2019
Native size-exclusion chromatography-mass spectrometry (nSEC-MS) is an analytical methodology that is appropriate for accurately quantitating the drug-to-antibody ratio (DAR) on a wide variety of interchain cysteine-linked antibody-drug conjugates (ADCs),
James Jones, Laura Pack, J. Hunter, John F. Valliere-Douglass   +3 more
semanticscholar   +1 more source

Fluorescence Correlation Spectroscopy Reveals Efficient Cytosolic Delivery of Protein Cargo by Cell-Permeant Miniature Proteins. [PDF]

, 2018
New methods for delivering proteins into the cytosol of mammalian cells are being reported at a rapid pace. Differentiating between these methods in a quantitative manner is difficult, however, as most assays for evaluating cytosolic protein delivery are
Knox, Susan L, Schepartz, Alanna, Steinauer, Angela, Thompson, Alexander D, Wissner, Rebecca F   +4 more
core   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Targeted Drug Delivery Using a Plug-to-Direct Antibody–Nanogel Conjugate [PDF]

, 2023
Uyen Huynh, Peidong Wu, Jingyi Qiu, Theeraphop Prachyathipsakul, Khushboo Singh, D. Joseph Jerry, Jingjing Gao, S. Thayumanavan   +7 more
openalex   +1 more source

A CD123-targeting antibody-drug conjugate, IMGN632, designed to eradicate AML while sparing normal bone marrow cells.

Blood Advances, 2018
The outlook for patients with refractory/relapsed acute myeloid leukemia (AML) remains poor, with conventional chemotherapeutic treatments often associated with unacceptable toxicities, including severe infections due to profound myelosuppression.
Y. Kovtun, Gregory E. Jones, Sharlene Adams, Lauren Harvey, C. Audette, Alan J. Wilhelm, Chen Bai, Lingyun Rui, Rassol Laleau, Fenghua Liu, O. Ab, Y. Setiady, Nicholas C. Yoder, V. Goldmacher, R. Chari, J. Pinkas, T. Chittenden   +16 more
semanticscholar   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Antibody Conjugation and Formulation [PDF]

, 2019
In an era where ultra-high antibody concentrations, high viscosities, low volumes, auto-injectors, and long storage requirements are already complex problems with the current unconjugated monoclonal antibodies on the market the formulation demands for ...
Alves, Nathan J.
core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source