Results 191 to 200 of about 145,743 (338)

Spleen‐Targeting Biomimetic Hybrid Nanocarriers for Systemic Immune Reprogramming in Colitis: RBC Membrane Vesicle‐Fused Lipid Nanoparticles

Advanced Functional Materials, EarlyView.
A spleen‐targeting hybrid nanoplatform (RBCMV‐LNP‐RP) harnessing erythrophagocytosis mimics senescent red blood cell clearance to achieve spleen‐specific delivery of rapamycin. This biomimetic system enables selective accumulation in splenic macrophages, orchestrating systemic immune reprogramming and promoting mucosal healing in an inflammatory bowel ...
Jun Kwon, Hee Su Sohn, Jong Sang Yoon, So Won Jeon, Hee Gyeong Ko, Min‐Ho Kang, Jisun Lee, Jae‐Hwan Nam, Louis T. Merriam, Edy Y. Kim, Han Young Kim   +10 more
wiley   +1 more source

Supplementary Figure S2 from Therapy-Induced Senescence Enhances the Efficacy of HER2-Targeted Antibody–Drug Conjugates in Breast Cancer

, 2023
Santiago Duro‐Sánchez, Mercedes Nadal‐Serrano, Marta Lalinde-Gutiérrez, Enrique J. Arenas, Cristina Bernadó Morales, Beatriz Morancho, Marta Escorihuela, Sandra Pérez‐Ramos, Santiago Escrivá-de-Romaní, Lucía Gandullo‐Sánchez, Atanasio Pandiella, Anna Esteve‐Codina, Verónica Rodilla, Fred A. Dijcks, Wim H.A. Dokter, Javier Cortés, Cristina Saura, Joaquı́n Arribas   +17 more
openalex   +1 more source

The Synthesis and Anticancer Activity of the Trastuzumab-Doxorubicin Antibody-Drug Conjugate Using Strain-Promoted Alkyne-Azide Coupling. [PDF]

ACS Omega
Thakur SK, Ghosh R, Chauhan N, Guchhait P, Eswaran SV.   +4 more
europepmc   +1 more source

Programmable DNA‐Peptide Hybrid Nanostructures for Potent Neutralization of Multiple Influenza a Virus Subtypes

Advanced Functional Materials, EarlyView.
A multivalent antiviral platform based on honeycomb‐shaped DNA nanostructures (HC–Urumin) is developed to enhance the potency and breadth of the host defense peptide Urumin. Through spatially patterned trimeric presentation, HC–Urumin disrupts influenza A virus entry, improves cell viability, and reduces disease severity in vivo‐offering a modular and ...
Saurabh Umrao, Abhisek Dwivedy, Payton L. Haak, Dhanush Gandavadi, Laurie A. Rund, Chi Chen, Vineetha Mareddy, Lifeng Zhou, Jinwei Duan, Ying Fang, Andrew J. Steelman, Xing Wang   +11 more
wiley   +1 more source

Use of Dupilumab to Manage Antibody-Drug Conjugate–Induced Cutaneous Toxicities

Ian Nykaza, Stephen W. Dusza, Jacob Rosenberg, Gopa Iyer, Emily Feld, Sarat Chandarlapaty, Komal Jhaveri, Kristine Peregrino Lacuna, Devika Gajria, Megan Bielawa, Alina Markova, Allison Gordon   +11 more
openalex   +2 more sources

Supplemental figures and legends from Antibody–Drug Conjugates Bearing Pyrrolobenzodiazepine or Tubulysin Payloads Are Immunomodulatory and Synergize with Multiple Immunotherapies

, 2023
Jonathan Rios‐Doria, Jay Harper, Raymond Rothstein, Leslie Wetzel, Jon Chesebrough, Allison M. Marrero, Cui Chen, Patrick Strout, Kathy Mulgrew, Kelly McGlinchey, Ryan Fleming, Binyam Bezabeh, John Meekin, D. J. Stewart, Maureen Shawn Kennedy, Philip Martin, Andrew Buchanan, Nazzareno Dimasi, Emil F. Michelotti, Robert E. Hollingsworth   +19 more
openalex   +1 more source

Expression of antibody-drug conjugate targets in soft tissue sarcomas. [PDF]

ESMO Open
Bertucci F, Finetti P, Mescam L, Monneur A, Frejafon A, Le Cesne A, Treilleux I, Italiano A, Brahmi M, Blay JY, Mamessier E.   +10 more
europepmc   +1 more source

Oral Dosed Organo‐Silica Nanoparticles Restore Glucose Homeostasis and β‐Cell Function in Diabetes Rats

Advanced Functional Materials, EarlyView.
An oral nanoplatform, MOP@T@D, which can maintain glucose homeostasis and restore islet β cells in diabetic rats is developed. It achieves efficient intestinal absorption and liver‐targeted delivery. The nanoparticle disintegrates only in response to hyperglycemia to release insulin on demand and provides antioxidant protection through selenoprotein ...
Chenxiao Chu, Mingli Wei, Che Bian, Xiaoshuang Bi, Yaxin Deng, Peifu Xiao, Jiansong Zhao, Yuying Wang, Haibing He, Jingxin Gou, Tian Yin, Xing Tang, Li Yang, Hongbo Zhang, Yu Zhang   +14 more
wiley   +1 more source

Supplementary Figure S6 from Endo180 (<i>MRC2</i>) Antibody–Drug Conjugate for the Treatment of Sarcoma [PDF]

Rachel J. Evans, Douglas W. Perkins, Joanna Selfe, Anna Kelsey, Gavin P. Birch, Janet Shipley, Koen Schipper, Clare M. Isacke   +7 more
openalex   +1 more source

High-efficiency gene transfer by adenovirus coupled to DNA-polylysine complexes [PDF]

, 1992
Agarwal, Santosh, Birnstiel, Max L., Cotten, Matt, Curiel, David T., Hu, P.-C., Li, C.-M., Loechel, S., Wagner, Ernst   +7 more
core   +1 more source