Results 111 to 120 of about 100,010 (342)

Targeting a Radiosensitizing Antibody–Drug Conjugate to a Radiation-Inducible Antigen

, 2021
Calvin D. Lewis, Abhay K. Singh, Fong‐Fu Hsu, Dinesh Thotala, Dennis E. Hallahan, Vaishali Kapoor   +5 more
openalex   +2 more sources

Targeted Drug Delivery Using a Plug-to-Direct Antibody–Nanogel Conjugate [PDF]

, 2023
Uyen Huynh, Peidong Wu, Jingyi Qiu, Theeraphop Prachyathipsakul, Khushboo Singh, D. Joseph Jerry, Jingjing Gao, S. Thayumanavan   +7 more
openalex   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

The blood-brain barrier limits the therapeutic efficacy of antibody-drug conjugates in glioblastoma [PDF]

, 2021
Roger Abounader, David Schiff
openalex   +1 more source

Site-selective protein-modification chemistry for basic biology and drug development. [PDF]

, 2015
Nature has produced intricate machinery to covalently diversify the structure of proteins after their synthesis in the ribosome. In an attempt to mimic nature, chemists have developed a large set of reactions that enable post-expression modification of ...
A Perols, A Sachdeva, AJ Keefe, B Fierz, B-Q Shen, BM Zeglis, C Chatterjee, C Goodman, CD Spicer, CT Walsh, D Schumacher, DP Nguyen, E Arbely, EM Pelegri-O'Day, EM Sletten, F Casadio, F Li, F Tian, Filipa P. da Cruz, G Pasut, GJL Bernardes, Gonçalo J. L. Bernardes, H Cho, H Neumann, HF Gaertner, HP Hemantha, J Li, J Li, J Madrzak, J Xie, J-M Kee, JI MacDonald, JL Seitchik, JM Chalker, JM Chalker, JM Chalker, JM Gilmore, JR Junutula, JY Axup, K Lang, K Lang, K Wang, KJ Hamblett, KP Chooi, L Davis, LN Tumey, M Rashidian, M Steiner, M Yang, MD Simon, N Stephanopoulos, N Toda, Nikolaus Krall, NS Beckley, Omar Boutureira, P Agarwal, P Dawson, P Wang, PM Drake, PMSD Cal, R Huang, R Rossin, R Serwa, RM Versteegen, RP Lyon, RVJ Chari, RVJ Chari, S Arur, S Tyagi, S Virdee, S Virdee, S Zheng, SI van Kasteren, SNS Alconcel, T Burckstummer, T Schneider, TS Elliott, TW Muir, W Liu   +78 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Original Multivalent Gold (III) and Dual Gold(III)-Copper(II) Conjugated Phosphorus Dendrimers as Potent Antitumoral and Antimicrobial Agents [PDF]

, 2017
Original metallophosphorus dendrimers (generation 3, 48 terminal groups) have been prepared via the complexation of phosphorus dendrimers bearing imino-pyridino end groups with Au(III) or with both Au(III) and Cu(II).
Serge M. Mignani, Nabil El Brahmi, Saïd El Kazzouli, Regis Laurent, Sonia Ladeira, Anne-Marie Caminade, Elzbieta Pedziwiatr-Werbicka, Eligia M. Szewcyk, Maria Bryszewska, Mosto M. Bousmina, Thierry Cresteil, Jean Pierre Majoral   +11 more
core   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy [PDF]

, 2015
Cancer is the second worldwide cause of death, exceeded only by cardiovascular diseases. It is characterized by uncontrolled cell proliferation and an absence of cell death that, except for hematological cancers, generates an abnormal cell mass or tumor.
Fernández-Medarde, Alberto, Pérez-Herrero, Edgar   +1 more
core   +1 more source