Results 191 to 200 of about 100,010 (342)

Fundamental research on Antibody-Drug Conjugates and their applications in solid tumors and hematologic malignancies

Shu Sun
openalex   +1 more source

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

The role of antibody-drug conjugates in the treatment of lung cancer. [PDF]

Front Oncol
Zlatanova T, Changalova A, Janzic U.
europepmc   +1 more source

Spleen‐Targeting Biomimetic Hybrid Nanocarriers for Systemic Immune Reprogramming in Colitis: RBC Membrane Vesicle‐Fused Lipid Nanoparticles

Advanced Functional Materials, EarlyView.
A spleen‐targeting hybrid nanoplatform (RBCMV‐LNP‐RP) harnessing erythrophagocytosis mimics senescent red blood cell clearance to achieve spleen‐specific delivery of rapamycin. This biomimetic system enables selective accumulation in splenic macrophages, orchestrating systemic immune reprogramming and promoting mucosal healing in an inflammatory bowel ...
Jun Kwon, Hee Su Sohn, Jong Sang Yoon, So Won Jeon, Hee Gyeong Ko, Min‐Ho Kang, Jisun Lee, Jae‐Hwan Nam, Louis T. Merriam, Edy Y. Kim, Han Young Kim   +10 more
wiley   +1 more source

Antibody-drug conjugates in prostate cancer: current landscape and future directions. [PDF]

Ther Adv Med Oncol
Ozay ZI, Hage Chehade C, Gebrael G, Ostrowski M, Sayegh N, Swami U, Agarwal N.   +6 more
europepmc   +1 more source

Supplementary Figure S2 from Therapy-Induced Senescence Enhances the Efficacy of HER2-Targeted Antibody–Drug Conjugates in Breast Cancer

, 2023
Santiago Duro‐Sánchez, Mercedes Nadal‐Serrano, Marta Lalinde-Gutiérrez, Enrique J. Arenas, Cristina Bernadó Morales, Beatriz Morancho, Marta Escorihuela, Sandra Pérez‐Ramos, Santiago Escrivá-de-Romaní, Lucía Gandullo‐Sánchez, Atanasio Pandiella, Anna Esteve‐Codina, Verónica Rodilla, Fred A. Dijcks, Wim H.A. Dokter, Javier Cortés, Cristina Saura, Joaquı́n Arribas   +17 more
openalex   +1 more source

Programmable DNA‐Peptide Hybrid Nanostructures for Potent Neutralization of Multiple Influenza a Virus Subtypes

Advanced Functional Materials, EarlyView.
A multivalent antiviral platform based on honeycomb‐shaped DNA nanostructures (HC–Urumin) is developed to enhance the potency and breadth of the host defense peptide Urumin. Through spatially patterned trimeric presentation, HC–Urumin disrupts influenza A virus entry, improves cell viability, and reduces disease severity in vivo‐offering a modular and ...
Saurabh Umrao, Abhisek Dwivedy, Payton L. Haak, Dhanush Gandavadi, Laurie A. Rund, Chi Chen, Vineetha Mareddy, Lifeng Zhou, Jinwei Duan, Ying Fang, Andrew J. Steelman, Xing Wang   +11 more
wiley   +1 more source

Pharmacokinetic and Pharmacodynamic Modeling of Antibody-Drug Conjugates. [PDF]

Cancers (Basel)
Glassman PM.
europepmc   +1 more source

Use of Dupilumab to Manage Antibody-Drug Conjugate–Induced Cutaneous Toxicities

Ian Nykaza, Stephen W. Dusza, Jacob Rosenberg, Gopa Iyer, Emily Feld, Sarat Chandarlapaty, Komal Jhaveri, Kristine Peregrino Lacuna, Devika Gajria, Megan Bielawa, Alina Markova, Allison Gordon   +11 more
openalex   +2 more sources

Supplemental figures and legends from Antibody–Drug Conjugates Bearing Pyrrolobenzodiazepine or Tubulysin Payloads Are Immunomodulatory and Synergize with Multiple Immunotherapies

, 2023
Jonathan Rios‐Doria, Jay Harper, Raymond Rothstein, Leslie Wetzel, Jon Chesebrough, Allison M. Marrero, Cui Chen, Patrick Strout, Kathy Mulgrew, Kelly McGlinchey, Ryan Fleming, Binyam Bezabeh, John Meekin, D. J. Stewart, Maureen Shawn Kennedy, Philip Martin, Andrew Buchanan, Nazzareno Dimasi, Emil F. Michelotti, Robert E. Hollingsworth   +19 more
openalex   +1 more source