Results 241 to 250 of about 100,010 (342)

Antibody-Drug Conjugates and Beyond: Next-Generation Targeted Therapies for Breast Cancer. [PDF]

Cancers (Basel)
Wali AF, El-Tanani M, Talath S, Rabbani SA, Rangraze IR, Satyam SM, Avagimyan A, Hoffmann K, Ilias I, Ispas S, Viviana M, Paczkowska A, Rizzo M.   +12 more
europepmc   +1 more source

Supplementary Figure 12 from Selective STING Activation in Intratumoral Myeloid Cells via CCR2-Directed Antibody–Drug Conjugate TAK-500

Vicky A. Appleman, Atsushi Matsuda, Michelle L. Ganno, Dong Mei Zhang, Emily Rosentrater, Angel E. Maldonado Lopez, Angelo Porciuncula, Tiquella Hatten, Camilla L. Christensen, Samantha A. Merrigan, Hong Myung Lee, Min Young Lee, Charlotte I. Wang, Linlin Dong, Jian Huang, Natasha Iartchouk, Jianing Wang, He Xu, Tomoki Yoneyama, Konstantin I. Piatkov, Satyajeet Haridas, Carole E. Harbison, Richard C. Gregory, Alexander Parent, Neil Lineberry, Chris Arendt, Kurt A. Schalper, Adnan O. Abu‐Yousif   +27 more
openalex   +1 more source

Nanothermometry in Living Cells: Physical Limits, Conceptual and Material Challenges

Advanced Functional Materials, EarlyView.
Heat and temperature are fundamental to life. When nanothermometers began probing regions as small as a living cell, they triggered controversial claims of large intracellular temperature gradients. We review physical constraints energy‐conservation, entropy production, thermodynamic fluctuations, and molecular dynamics.
Taras Plakhotnik
wiley   +1 more source

Supplementary Figure 5 from Selective STING Activation in Intratumoral Myeloid Cells via CCR2-Directed Antibody–Drug Conjugate TAK-500

Vicky A. Appleman, Atsushi Matsuda, Michelle L. Ganno, Dong Mei Zhang, Emily Rosentrater, Angel E. Maldonado Lopez, Angelo Porciuncula, Tiquella Hatten, Camilla L. Christensen, Samantha A. Merrigan, Hong Myung Lee, Min Young Lee, Charlotte I. Wang, Linlin Dong, Jian Huang, Natasha Iartchouk, Jianing Wang, He Xu, Tomoki Yoneyama, Konstantin I. Piatkov, Satyajeet Haridas, Carole E. Harbison, Richard C. Gregory, Alexander Parent, Neil Lineberry, Chris Arendt, Kurt A. Schalper, Adnan O. Abu‐Yousif   +27 more
openalex   +1 more source

Recent Technological and Intellectual Property Trends in Antibody–Drug Conjugate Research [PDF]

Youngbo Choi, Y. Choi, Surin Hong
openalex   +1 more source

Receptor-mediated gene delivery employing lectin-binding specificity [PDF]

, 1994
Batra, R. K., Curiel, David T., Garver, R. I., Wagner, Ernst, Wang-Johanning, F.   +4 more
core  

Gold Nanoclusters as Dual Agents for Engineering Tumor Vascular Leakiness and Performing Photothermal Therapy

Advanced Functional Materials, EarlyView.
Many cancer nanotherapeutics, while potent, suffer from the inability to escape from the tumor vasculature, especially in the absence of endothelial permeability. In this work, ultrasmall gold nanoclusters could engineer nanomaterials induced endothelial leakiness (NanoEL) and harness strong NIR induced photothermal characteristics to suppress tumor ...
Nengyi Ni, Kuoran Xing, Bihan Zhang, Baoteng Wang, Yinglu Chen, Jianping Xie, Xiao Sun, Jinping Wang, David Tai Leong   +8 more
wiley   +1 more source

Clinical applications of antibody-drug conjugates in advanced non-small cell lung cancer. [PDF]

Front Immunol
Guo H, Xu Z, Li K, Guo C, Lin F, Pu Q, Wang G.   +6 more
europepmc   +1 more source

Tissue Engineered Human Elastic Cartilage From Primary Auricular Chondrocytes for Ear Reconstruction

Advanced Functional Materials, EarlyView.
Despite over three decades of research, no tissue‐engineered solution for auricular reconstruction in microtia patients has reached clinical translation. The key challenge lies in generating functional elastic cartilage ex vivo. Here, we integrate synergistic cell‐biomaterial strategies to engineer auricular grafts with mechanical and histological ...
Philipp Fisch, Sandra Kessler, Simone Ponta, Anna Puiggalí‐Jou, Guoliang Lyu, Killian Flégeau, Anastasiya Martyts, Florian Roth, David Fercher, Filippo M. Rijli, Daniel Simmen, Eva Novoa Olivares, Thomas Linder, Marcy Zenobi‐Wong   +13 more
wiley   +1 more source

Homogeneous antibody-drug conjugates

Despite advances in medical care, cancer remains a major threat to human health. Antibody-drug conjugates (ADCs) are a promising targeted therapy to overcome adverse side effects to normal tissues. In this field, the current challenge is obtaining homogeneous preparations of conjugates, where a defined number of drugs are conjugated to specific ...
Farràs Mañé, Marta||, Miret, Joan||, Camps, Marc||, Román, Ramón||, Martínez, Óscar||, Pujol, Xavier||, Erb, Stéphane, Ehkirch, Anthony||, Cianferani, Sarah||, Casablancas, Antoni||, Cairó i Badillo, Jordi Joan||   +10 more
openaire   +1 more source